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  • 1
    Electronic Resource
    Electronic Resource
    Sequence divergence of rainbow trout protamine mRNAs; comparison of coding and non-coding nucleotide sequences in three protamine cDNA plasmids (1979)
    [s.l.] : Nature Publishing Group
    Nature 279 (1979), S. 809-811 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The sequences of the cloned cDNA fragments were determined by the methods of Maxam and Gilbert8. Figure 1 is a representative sequence ladder and Fig. 2 shows the extent of the cloned sequences aligned with reference to the functional chain terminator codon TAG. pTP4 contains a complete coding ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/279809a0
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  • 2
    Electronic Resource
    Electronic Resource
    Mouse p53 inhibits SV40 origin-dependent DNA replication (1987)
    [s.l.] : Nature Publishing Group
    Nature 329 (1987), S. 458-460 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Replication experiments were carried out by transfecting SV40 origin-containing plasmids into the SV40-transformed monkey COS cell line15 which is permissive for SV40 replication. The plasmids are described in the legend to Fig. 1. Figure la shows that plasmids CMVmspSS and CMVdll62 are restricted ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/329458a0
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  • 3
    Electronic Resource
    Electronic Resource
    Human DNA topoisomerases IIα and IIβ can functionally substitute for yeast TOP2 in chromosome segregation and recombination (1996)
    Springer
    Molecular genetics and genomics 252 (1996), S. 79-86 
    Details
    ISSN: 1617-4623
    Keywords: Key words Topoisomerases ; Chromosome segregation ; Genetic recombination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The ability of the human DNA topoisomearse IIα and IIβ isozymes to complement functional defects conferred by conditional top2 mutations in Saccharomyces cerevisiae has been investigated. At the restrictive temperature, top2 strains show multiple abnormalities, including an inability to complete mitotic and meiotic division owing to a defect in chromosome segregation, and hyper-recombination within the repetitive rDNA gene cluster. We show that the human topoisomerases IIα and IIβ can each support both vegetative growth and the production of viable spores in a top2-4 mutant at the restrictive temperature. Similarly, both human isozymes can rescue a strain carrying a top2 gene disruption, and suppress hyper-recombination within the rDNA gene cluster. We conclude that the human topoisomerase IIα and IIβ isozymes are functionally interchangeable with yeast topoisomerase II and suggest that any isozyme-specific roles in human cells are likely to be dependent upon factors other than inherent differences in catalytic ability between the α and β isozymes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004389670009
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  • 4
    Electronic Resource
    Electronic Resource
    Human DNA topoisomerases IIα and IIβ can functionally substitute for yeastTOP2 in chromosome segregation and recombination (1996)
    Springer
    Molecular genetics and genomics 252 (1996), S. 79-86 
    Details
    ISSN: 1617-4623
    Keywords: Topoisomerases ; Chromosome segregation ; Genetic recombination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The ability of the human DNA topoisomerase IIα and IIβ isozymes to complement functional defects conferred by conditionaltop2 mutations inSaccharomyces cerevisiae has been investigated. At the restrictive temperature,top2 strains show multiple abnormalities, including an inability to complete mitotic and meiotic division owing to a defect in chromosome segregation, and hyper-recombination within the repetitive rDNA gene cluster. We show that the human topoisomerases IIα and IIβ can each support both vegetative growth and the production of viable spores in atop2-4 mutant at the restrictive temperature. Similarly, both human isozymes can rescue a strain carrying atop2 gene disruption, and suppress hyper-recombination within the rDNA gene cluster. We conclude that the human topoisomerase IIα and IIβ isozymes are functionally interchangeable with yeast topoisomerase II and suggest that any isozyme-specific roles in human cells are likely to be dependent upon factors other than inherent differences in catalytic ability between the α and β isozymes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02173207
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of novobiocin on yeast topoisomerase type II (1990)
    Springer
    Molecular genetics and genomics 220 (1990), S. 256-260 
    Details
    ISSN: 1617-4623
    Keywords: Topoisomerase II ; Affinity-chromatography ; Novobiocin ; Novobiocin-sepharose ; Novobiocin-resistant mutants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Low concentrations of novobiocin are toxic to permeable yeast cells, but do not inhibit type II topoisomerase activity. Furthermore, the enzyme does not bind specifically to novobiocin-Sepharose. These observations are in agreement with genetical analyses. Mutations at a single locus that confer novobiocin resistance and temperature sensitivity exhibit a similar phenotype to cells treated with novobiocin, but are not topoisomerase II mutants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00260491
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  • 6
    Electronic Resource
    Electronic Resource
    The omnipotent suppressor SUP45 affects nucleic acid metabolism and mitochondrial structure (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 6 (1990), S. 441-450 
    Details
    ISSN: 0749-503X
    Keywords: Saccharomyces cerevisiae ; novobiocin-resistance ; SUP45 ; nucleic acid synthesis ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Yeast (Saccharomyces cerevisiae) strains sensitive to a variety drugs were used to select for novobiocin-resistant mutants that were simultaneously temperature-sensitive. The mutants remained as sensitive as the parent strains to a wide range of drugs other than novobiocin, and did not exhibit any suppression of suppressible auxotrophic markers. At the non-permissive temperature, the mutant cells arrested mainly as unbudded cells, and were instantly defective in DNA and RNA synthesis, but not protein synthesis. The cloned wild-type gene was identified as SUP45, which has been previously implicated in the translation process. Our results suggest that SUP45 may have a function in addition to, or different from, the one that has been assigned to it previously.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320060509
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    Paper (German National Licenses)
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