Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Complement and experimental respiratory failure (1986)
    Springer
    Intensive care medicine 12 (1986), S. 17-21 
    Details
    ISSN: 1432-1238
    Keywords: Complement ; Oxygen radicals ; Lung injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Activation of the complement system within the lung can lead to acute pulmonary damage and dysfunction. Based on a variety of experimental models it is now apparent that lung injury is related to complement-induced generation of oxygen derived free radicals from neutrophils and from macrophages. In addition to the oxygen radicals, it is also possible that the conversion of hydrogen peroxide by myeloperoxidase to hypochlorous acid also contributes to the injury. Exposure of the pulmonary microvasculature to oxygen radicals generated from complement-activated neutrophils causes focal damage and necrosis of endothelial cells. IgG immune complex-induced injury of lung is also complement and neutrophil dependent and oxygen radical mediated. In contrast, lung injury produced by IgA immune complexes is neutrophil independent, complement dependent and oxygen radical mediated. There is now increasing evidence that oxygen radicals are not only directly tissue-toxic but also able to potentiate the activity of leukocytic proteases. In all of these models the lung can be protected from injury by pretreatment of the animals with either scavengers of hydroxyl radical or with agents that prevent its formation (e.g. catalase, iron chelators). Data from these models may have direct clinical relevance to conditions such as adult respiratory distress syndrome where lung injury is probably oxygen radical mediated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315362
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Confirmation and refinement of the localisation of the c-MEL locus on chromosome 19 by physical and genetic mapping (1989)
    Springer
    Human genetics 〈Berlin〉 81 (1989), S. 382-384 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The human gene locus c-MEL was identified following transfection of genomic DNA from the human melanoma cell line NK14; it has previously been assigned to chromosome 19 (p13.2–q13.2) by analysis of somatic cell hybrids. We have further refined the position of this gene to the proximal region of 19p (cen-p13.2), using cell hybrids containing only fragments of human chromosome 19. We have confirmed this physical localisation by linkage analysis with a recently described restriction fragment length polymorphism for the c-MEL gene, and mapped the locus within the region of the low density lipoprotein receptor gene (LDLR) (Lod 4.43, $$\hat \theta = 0.10$$ ) and the anonymous marker D19S11 (13.1.25) (Lod 9.33, $$\hat \theta = 0$$ ). This gene thus maps to a region of chromosome 19 involved in karyotypic abnormalities in a variety of malignancies including melanomas and leukaemias.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00283697
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    MRI in the management of scaphoid fractures in skeletally immature patients (2000)
    Springer
    Pediatric radiology 30 (2000), S. 685-688 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The scaphoid is the commonest fractured carpal bone, but excluding a scaphoid fracture with plain radiographs is difficult. Other imaging modalities are being increasingly evaluated in the management of scaphoid injuries. MRI has been shown to be of considerable value in the adult population but there have been limited studies of its use in children.¶Purpose. To evaluate the role of MRI in the acute management of suspected scaphoid injuries in children.¶Methods and materials. Fifty-six children (57 injuries) who had a suspected scaphoid injury underwent MRI within 10 days of their initial trauma. The results of MRI were used to dictate management of the injury.¶Results. In 33 (58 %) of the 57 injuries, MRI was normal and the patient was discharged from care. In 16 cases (28 %), a fractured scaphoid was diagnosed and appropriate treatment started early. Additionally, other fractures around the wrist joint and ganglion cysts were demonstrated on MRI.¶Conclusions. MRI of acute scaphoid injuries in children significantly alters management. Those children with normal scans are discharged earlier. Scaphoid fractures are confirmed earlier and other pathological conditions are also detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002470000305
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Pheromone emission and blend percentages inEoreuma loftini determined by two methods (1989)
    Springer
    Journal of chemical ecology 15 (1989), S. 105-120 
    Details
    ISSN: 1573-1561
    Keywords: Sex pheromones ; pheromone adsorption ; age ; pheromone emission ; Lepidoptera ; Pyralidae ; Crambinae ; Eoreuma loftini ; calling behavior ; (Z)-11-hexadecenyl acetate ; (Z)-13-octadecenyl acetate ; (Z)-13-octadecenal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Calling behavior and pheromone emission by virgin femaleE. loftini moths were investigated in laboratory experiments. Calling peaked during the last three hours of the night. Three-day-old moths called more than older or younger moths and began calling earlier in the night than younger moths. Female emissions were collected in flasks without airflow and cylinders with airflow. Control tests indicated that the pheromone components (Z)-11-hexadecenyl acetate (HDA) and (Z)-13-octadecenylacetate (ODA) were 69 and 54% adsorbed on moths, respectively, and the component (Z)-13-octadecenal (ODL) was 92–99% adsorbed depending on its concentration, when put into flasks with noncalling females for 4 hr. Pheromone exposed to moths for less than 4 hr was adsorbed less. After correction for adsorption, the pheromone blend from females calling in flasks was 9:42:49% of HDA/ODL/ODA with an overall emission rate of 58 ng/female/4 hr. Three-day-old females emitted more pheromone than 0- to 2- or 4- to 5-day-old moths, in flasks. Little or no pheromone put into cylinders either downwind or upwind from a male moth was adsorbed by the moth. The pheromone blends from females calling in cylinders, corrected using downwind and upwind control test results, respectively, were 15:35:50 and 13:40:48% of HDA/ODL/ODA with overall emission rates of 32 and 35 ng/female/night.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02027777
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Nonspecific protease and elastase activities in rat leukocytes (1982)
    Springer
    Inflammation 6 (1982), S. 177-187 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Extracts were prepared from rat peritoneal leukocytes obtained 4 h after glycogen injection and assayed for proteolytic enzyme activities against various substrates. The substrates used included acid-denatured bovine hemoglobin, bovine serum albumin, a partially purified preparation of rat pulmonary basement membrane, bovine neck ligament elastin, and an artificial substrate with elastase specificity. A high level of activity was observed when hemoglobin was used as the substrate. The serum albumin and basement membrane preparation were also readily hydrolyzed by the leukocyte extract. In contrast, the native elastin and synthetic elastase substrate were much more resistant. Although the leukocyte extract demonstrated little intrinsic elastase activity, when it was mixed with a commercial hog pancreatic elastase preparation, it greatly potentiated the elastolytic activity, suggesting the activation of a latent enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00916242
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...