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  • 1
    Electronic Resource
    Electronic Resource
    Gastrointestinal blood loss associated with running a marathon (1986)
    Springer
    Digestive diseases and sciences 31 (1986), S. 1229-1232 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gastrointestinal bleeding has been observed in long-distance runners. We prospectively studied participants of the Eighth Annual Marine Corps Marathon to determine the incidence of gastrointestinal blood loss associated with long-distance running. Of 600 runners contacted, 125 (21%) returned a questionnaire as well as pre- and postmarathon stool specimens. Stool specimens converted from Hemoccult negative to positive in 29/125 (23%) of the participants, indicating that running the marathon was associated with gastrointestinal blood loss (P〈0.001). The incidence of this conversion (negative to positive) was significant for both males (N=68,P〈0.001) and females (N=57,P〈0.05). Gastrointestinal bleeding appeared to be independent of age, race time, abdominal symptoms, and the recent ingestion of aspirin, vitamin C, or steak.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296525
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  • 2
    Electronic Resource
    Electronic Resource
    Cycling, a manometric phenomenon due to repetitive episodes of gastroesophageal reflux and clearance (1989)
    Springer
    Digestive diseases and sciences 34 (1989), S. 1340-1348 
    Details
    ISSN: 1573-2568
    Keywords: Esophagus ; simultaneous manometry ; pH monitoring ; scintigraphy ; gastroesophageal reflux ; cycling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied intraesophageal pressure changes in patients with symptoms of gastroesophageal reflux and an abnormal 24-hr pH monitoring record (N=52). Our method was simultaneous esophageal manometry and pH monitoring. We observed a three-component esophageal manometric sequence (EMS). When this sequence recurred over and over, we termed this phenomenon “cycling.” We found cycling in 35% of the patients (18/52). Those with cycling had lower basal LES pressures, more acid exposure, and an increased incidence of endoscopic esophagitis. That cycling resulted from repeated reflux events and their esophageal clearance was documented by scintigraphy during simultaneous manometry and pH monitoring (N=7 patients). Cycling was found on the routine esophageal manometry record of 25% of symptomatic patients (N=112) with an abnormal 24-hr pH score. In conclusion, cycling represents an esophageal manometric phenomenon due to repetitive reflux events. Its recognition during esophageal manometry may denote a severe reflux diathesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01538066
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Esophageal prosthesis in cancer (1978)
    Springer
    Digestive diseases and sciences 23 (1978), S. 796-800 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe the use of polyvinyl esophageal prosthetic tubes to treat 14 consecutive patients with malignant strictures and tracheoesophageal fistula from carcinoma of the esophagus. We found these prosthetic tubes easy to construct, simple to insert, and that their use improved the quality of remaining life in most patients by diminishing dysphagia and incessant coughing from pulmonary aspiration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01079788
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Pulmonary aspiration as a consequence of gastroesophageal reflux (1979)
    Springer
    Digestive diseases and sciences 24 (1979), S. 839-844 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A radioisotope scintiscanning technique that can document pulmonary aspiration of gastric contents in patients with gastroesophageal reflux is described. Six patients with suspected nocturnal aspiration from reflux were studied. Three of the six had positive lung scans 8 hr after intragastric placement of 10 mCi of technetium 99m sulfur colloid. Overnight intraesophageal pH monitoring revealed prolonged episodes of GE reflux in those with positive scans. These preliminary observations suggest that this scintigraphic technique may be an effective method for documenting pulmonary symptoms as a consequence of gastroesophageal reflux.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01324899
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Esophageal hematoma (1981)
    Springer
    Digestive diseases and sciences 26 (1981), S. 1019-1024 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report four cases of esophageal hematoma and emphasize that endoscopically and radiographically it may simulate a neoplasm. After a review of 26 cases, we found that patients with normal hemostasis often had esophageal hematoma occur distally after vomiting. Most of these hematomas probably originated from a Mallory-Weiss laceration. In contrast, patients with impaired hemostasis had esophageal hematoma occur proximally or at multiple sites. Many of these hematomas occurred spontaneously, without a history of vomiting, and probably resulted from impaired coagulation. Regardless of etiology most esophageal hematomas were associated with a benign course.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314765
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  • 6
    Electronic Resource
    Electronic Resource
    Esophageal epithelial response to gastroesophageal reflux (1978)
    Springer
    Digestive diseases and sciences 23 (1978), S. 498-509 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Exposure of the distal esophageal mucosa to acid gastric juice was quantitated by 24-hr pH monitoring in 100 individuals and was correlated with morphologic data derived from esophageal biopsies. The degree of acid exposure to the distal esophagus correlated directly with increases in both relative and absolute length of the subepithelial papillae and to relative basal zone hyperplasia. Both papillary length and basal zone hyperplasia decreased after antireflux surgery had reduced acid exposure to normal. Reflux in the recumbent position resulted in prolonged exposure of the mucosa to acid because of poor acid clearing from the esophagus. This caused longer papillae than did upright reflux, where there were more frequent reflux episodes, but with rapid acid clearance. The presence of a hiatal hernia was associated with longer papilae, lower DES pressure, increased reflux frequency, and prolonged recumbent acid clearance. Twenty-four hour pH monitoring correlated better with papillary length than did symptoms or other clinical measures of gastroesophageal reflux.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01072693
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Biliary obstruction (1979)
    Springer
    Digestive diseases and sciences 24 (1979), S. 145-149 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Extrahepatic biliary obstruction resulted from chronic alcoholic pancreatitis in seven patients. All cases had a characteristic smooth symmetrical narrowing of the intrapancreatic portion of the common bile duct on retrograde cholangiography. Both medical and surgical therapy for their disorder is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01324742
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  • 8
    Electronic Resource
    Electronic Resource
    Esophageal acid clearance during sleep in patients with Barrett's esophagus (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 654-659 
    Details
    ISSN: 1573-2568
    Keywords: gastroesophageal reflux ; sleep ; Barrett's esophagus ; acid clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sleep-related gastroesophageal reflux and esophageal acid clearance have been shown to be important components in the pathogenesis of reflux esophageal disease. Previous studies have suggested that patients with more severe esophagitis are distinguished by an accumulation of acid mucosal contact time during sleep. These data would suggest that patients with Barrett's esophagus should have particularly severe impairment of acid clearance, most notable during sleep. To address this issue, 16 asymptomatic healthy volunteers and 13 patients with Barrett's esophagus were studied. Acid clearance was assessed by timing the reestablishment of an esophageal pH of 4 following the infusion of 15 ml 0.1 N HCl. Sleep was poly graphically monitored in order to objectively determine sleep and waking. The results indicated that while patients with Barrett's esophagus had a marked increase in the frequency of spontaneous gastroesophageal reflux during sleep, they unexpectedly demonstrated faster acid clearance times during both waking and sleep. A greater percentage of arousal responses to acid infusion during sleep was noted in the Barrett's group. It is concluded from these results that patients with Barrett's esophagus can adequately clear acid from the distal esophagus but experience considerable acid mucosal contact through repeated episodes of spontaneous reflux during sleep.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540426
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Pill-induced esophageal injury (1983)
    Springer
    Digestive diseases and sciences 28 (1983), S. 174-182 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report four cases of esophageal injury associated with the ingestion of commonly prescribed tablets or capsules. History and clinical characteristics of these cases suggest that the medications failed to transit the esophagus and acted locally to produce esophagitis. A search of English- and foreign-language medical journals documented 221 similar cases due to 26 different types of medication. While most of these esophageal injuries are self-limited and produce no morbidity beyond transient retrosternal pain, odynophagia, and dysphagia, major complications have occurred, such as mediastinal penetration, hemorrhage, and death. Patients should be counseled to take pills in an upright posture with liberal amounts of fluid well before retiring for the night.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01315148
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  • 10
    Electronic Resource
    Electronic Resource
    Tauroursodeoxycholic acid is less damaging than taurochenodeoxycholic acid to the gastric and esophageal mucosa (1983)
    Springer
    Digestive diseases and sciences 28 (1983), S. 359-364 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bile acids are capable of disrupting the gastric and esophageal mucosal barriers and are known to differ in their ability to injure these mucosae. Two bile acids, chenodeoxycholic and its 7-B epimer, ursodeoxycholic, that are being used to dissolve gallbladder stones were evaluated for their damaging effects on experimental preparations of the esophageal (rabbit) and gastric (dog) mucosa. Damage was assessed by measuring indices of mucosal barrier function, including net acid flux, potential difference, and tissue resistance, before and after exposure to the taurine conjugates of these bile acids. In both the esophageal and gastric mucosa, tauroursodeoxycholic acid caused significantly less disruption of barrier function than taurochenodeoxycholic acid. These results demonstrate that minor differences in conjugated bile acid structure can cause major changes in the effects of bile acids on the upper gastrointestinal mucosa and that ursodeoxycholic acid may be the preferred bile acid for oral ingestion to dissolve gallbladder stones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01324955
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