ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. Prolonged oral administration of NG-nitro-l-arginine (l-NNA) for a period of 5 weeks in 8 week old male normotensive Wistar-Kyoto (WKY) rats n= 10), induced hypertension in all animals. Hypertension was characterized by a sharp initial increase in both systolic blood pressure (SBP) and mean blood pressure (MBP) until the third day (from 126 ± 3 mmHg to 160 ± 6 mmHg and from 95 ± 3 mmHg to 133 ± 6 mmHg, respectively). This was followed by a gradual and steady increase until the fourth week (163 ± 4, 171 ± 3 and 189 ± 8 mmHg for SBP in weeks 1, 2 and 4, respectively; and 135 ± 4, 143 ± 3and 157 ±5 mmHg for MBP in weeks 1, 2 and 4, respectively).2. Intravenously L-arginine-HCl (500 mg/kg) administered on the last day of the 5th week abolished the effect of dietary l-NNA on the arterial blood pressure.3. Dietary l-NNA-induced hypertension in WKY rats is easily obtainable and free of any surgical operation, and can be utilized as a new experimental model to further understand the importance of endothelium-dependent relaxing factor/nitric oxide in blood pressure regulation and to clarify the pathological significance in intact animals where endothelium-dependent relaxing factor/nitric oxide is functionally involved.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1992.tb00508.x
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