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  • 1
    Electronic Resource
    Electronic Resource
    The use of paediatric chemotherapy protocols at full dose is both a rational and feasible treatment strategy in adults with Ewing's family tumours (1997)
    Springer
    Annals of oncology 8 (1997), S. 1099-1105 
    Details
    ISSN: 1569-8041
    Keywords: chemotherapy ; dose intensity ; Ewing's sarcoma ; primitive neuroectodermal tumour ; toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Ewing's sarcoma and primitive neuroectodermal tumour (ES/PNET) are rare, limiting opportunities for therapy studies in adults. Chemotherapy regimens adapted from paediatric studies are often used for adults but concerns about poor outcome and treatment toxicity may adversely affect drug dose intensity. We present our experience using a paediatric protocol at full dose. Patients and methods: Records of 34 patients with ES/PNET who received the IVAD chemotherapy regimens were reviewed. Received drug dose intensity, toxicity and survival data were collected. Results: Received dose intensity in 30 evaluable patients was 0.92 compared to the standard IVAD schedule. Myelosuppression was the major toxicity, 83% of patients experienced grade 4 neutropenia. There was no major renal or cardiac toxicity. In patients without metastases at presentation, five-year overall survival was 63% and progression free survival was 39%. Tumour burden at presentation was statistically significantly associated with survival (P = 0.002). The five-year survival rate of 80% in patients presenting with low volume non metastatic disease was equivalent to published paediatric series. Conclusions: Although the IVAD chemotherapy regimens are myelotoxic in adults, they can be given safely. We recommend that adults with ES/PNET should be included in current multicentre, multidisciplinary treatment studies directed at children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008264902857
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  • 2
    Electronic Resource
    Electronic Resource
    Preclinical toxicology, pharmacokinetics and formulation of N 2 , N 4 , N 6 -trihydroxymethyl-N 2 , N 4 , N 6 -trimethylmelamine (Trimelamol), a water-soluble cytotoxic s-triazine which does not require metabolic activation (1986)
    Springer
    Cancer chemotherapy and pharmacology 17 (1986), S. 251-258 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary N 2 , N 4 , N 6 -Trihydroxymethyl-N 2 , N 4 , N 6 -trimethylmelamine (Trimelamol) is a water-soluble synthetic s-triazine which, unlike hexamethylmelamine (HMM) and pentamethylmelamine (PMM), does not require metabolic activation. The physico-chemical characteristics of Trimelamol were studied with the aim of overcoming the problems of chemical instability, low solubility and polymerisation which had hindered the development of the drug for clinical use. Trimelamol had similar activity to PMM against the murine PC6 plasmacytoma, but enhanced activity with respect to PMM against the Walker 256 carcinosarcoma in the rat, a species which metabolises PMM less efficiently. Pharmacokinetic studies in mouse, rat and man did not show the major species differences characteristic of PMM. The drug exhibited similar toxicity to PMM against rodents, but had virtually no neurotoxicity. The potential advantages of Trimelamol over previously tested melamines are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256694
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  • 3
    Electronic Resource
    Electronic Resource
    Cis-dichlorodiammineplatinum (Cis-platinum) and etoposide (VP-16) in malignant lymphoma — an effective salvage regimen (1985)
    Springer
    Cancer chemotherapy and pharmacology 14 (1985), S. 258-261 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Response rates in malignant lymphoma after failure of first-line therapy are generally poor. Twenty-five patients with non-Hodgkin's lymphoma (NHL) unresponsive to standard combination chemotherapy were treated with cis-platinum/VP-16. Alo were heavily pretreated, 29% having received three or more different drug regimens. Seventeen patients were evaluable for response. There were five complete remissions (CR) (29%) and four partial remissions (PR) (24%), giving an overall response rate of 53% (36% of all patients treated). The duration of CR was 12–48 weeks. Median survival for responders was 25 weeks (15–95), compared with only 5 weeks (4–17) for non-responders (P=0.002). Toxicity included nausea and vomiting, alopecia, minor renal impairment, and myelosuppression. This was sometimes severe: WBC〈1.0x109/l in three patients (18%) and platelets〈50x109/l in five patients (29%). The response rate for this combination is superior to that reported for either cisplatinum or VP-16 alone in similar patients (PR only 26% and 20%–30%, respectively). Further investigation is required to define the role of these drugs in the first-line treatment of poor-prognosis NHL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258129
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  • 4
    Electronic Resource
    Electronic Resource
    Letter to the editors (1987)
    Springer
    Cancer chemotherapy and pharmacology 20 (1987), S. 181-182 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253977
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    Paper (German National Licenses)
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