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  • 1
    Digitale Medien
    Digitale Medien
    ALLOGENEIC RESTRICTION IN THE RAT: GENETIC BASIS OF RESTRICTION OF THE T CELL MEDIATORS OF DELAYED-TYPE HYPERSENSITIVITY AND ANTIMICROBIAL RESISTANCE TO LISTERIA MONOCYTOGENES (1980)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 7 (1980), S. 0 
    Details
    ISSN: 1744-313X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: The genetic basis of the restriction imposed on T cell mediating acquired antimicrobial resistance and delayed-type hypersensitivity (DTH) to Listeria in the rat was investigated. Sharing of MHC-coded genes between donors of sensitized T cells and antigen-stimulated recipients was both necessary and sufficient for efficient transfer of both resistance and DTH. Evidence to support this assumption was derived from experiments involving allogeneic transfers within major histocompatibility complex (MHC)-compatible strains and across MHC-barriers. Further support came from linkage studies with backcrossed rats and with the progeny of F1 rats mated with an unrelated strain. An unexpected difference in the compatibility requirements for effective transfer of DTH and resistance was noted in experiments involving the BI strain (formerly called B3). Thus, while B-region compatibility was obligatory for expression of DTH in recipients of sensitized T cells, considerable levels of protection could be transferred to either A-region or B-region compatible hosts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1744-313X.1980.tb00934.x
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  • 2
    Digitale Medien
    Digitale Medien
    GENETIC CONTROL OF CELL-MEDIATED IMMUNITY IN THE RAT:II. SHARING OF EITHER THE RTI. A OR RTI. B LOCUS IS SUFFICIENT FOR TRANSFER OF ANTIMICROBIAL RESISTANCE (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: The MHC restriction criteria for T cells activating macrophages in vivo and mediating antimicrobiol resistance to Listeria monocytogenes were determined. Antimicribiol resistance could be transferred by T cell in order of decreasing efficiency from syngeneic. RT1A. compatible, RTI.B compatible and RT1 incompatible donors. Alloreactive T cells responding to either A locus or B locus encoded antigens in a graft-versus-host reaction were also able to activate macrophages. Approximately five times as many MLC-reactive precursors responded to B locus alloantigens as to A locus alloantigens, but A-resticted Listeria-specific T cells wre considerably more numerous (or more efficient) in Listeriainfected hosts than were B-restricted, Listeria-specific T cells. This was unexpected, since A-restricted, Listeria-specific T cells failed to transfer delayed hypersensitivity (DTH) to soluble bacterial antigens.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb01005.x
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  • 3
    Digitale Medien
    Digitale Medien
    GENETIC CONTROL OF CELL-MEDIATED IMMUNITY IN THE RAT. I. TRANSFER OF DTH TO BACTERIAL ANTIGENS IS RESTRICTED BY THE B REGION OF RT1. (1981)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 8 (1981), S. 0 
    Details
    ISSN: 1744-313X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: The genetic basis of allogeneic restriction in the transfer of delayed type hypersensitivity (DTH) to soluble Listeria monocytogenes antigens (LMA) in rats was analysed using a set of congenic strains. The DTH parameter assayed was the localization of radiolabelled donor lymphoblasts in subcutaneous antigen stimulation sites in the ear. Sharing of the RT1.B region between the donor and host was essential for the transfer of DTH to LMA, which suggests that the RT1.B region codes for restriction elements controlling antigen recognition by TDTH cells. The recombinant haplotype RT1r1 was exceptional in that transfer of DTH to A-region matched recipients was, at least in part, possible. Measurement of donor lymphoblast localization in DTH sites afforded an opportunity to quantify allogeneic effects influencing localization of sensitized donor cells in DTH sites borne by alien recipients. Both RT1.B and RT1.A region differences could induce allogeneic effects, but they were an order of magnitude lower than those based on restricted recognition by donor T cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1744-313X.1981.tb00939.x
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  • 4
    Digitale Medien
    Digitale Medien
    Change in sensitivity to lipopolysaccharide during the differentiation of human monocytes to macrophages in vitro (1994)
    Springer
    Cellular and molecular life sciences 50 (1994), S. 110-114 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Monocytes ; macrophages ; procoagulant activity ; tumor necrosis factor (TNF) ; lipopolysaccharide (LPS) ; macrophage activation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Mononuclear phagocytes in distinct differentiation stages and cultured under different conditions were tested for their sensitivity towards lipopolysaccharide (LPS), using procoagulant activity (PCA) expression and tumor necrosis factor (TNF) production as indices. The response of mature monocyte-derived macrophages differed from that of freshly isolated monocytes 1) by higher levels of constititive PCA, 2) by responding to approximately 1,000-fold lower concentrations of LPS with PCA and TNF production, and 3) by a faster rise in PCA and TNF production. Due to the high constitutive level of PCA expression, the PCA stimulation index for LPS was low in macrophages when compared with that in monocytes. Thus, during differentiation to macrophages, human monocytes acquire increased sensitivity to LPS (2 orders of magnitude more sensitive than a sensitive turbidimetricLimulus amoebocyte lysate assay). This exquisite sensitivity to LPS is expressed regardless of whether LPS is offered in the presence or absence of lipopolysaccharide binding protein-containing serum. This points to as yet uncharacterized pathways of high affinity interaction between LPS and macrophages.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01984945
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  • 5
    Digitale Medien
    Digitale Medien
    The capacity of various types of immunoglobulin for intravenous use to interact with Fc receptors of human monocytes and macrophages (1986)
    Springer
    Annals of hematology 53 (1986), S. 321-332 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Monocytes ; Macrophages ; Fc receptors ; Intravenous Immunoglobulin ; Phagocytosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The capacity of immunoglobulin for intravenous application (IgG-IV) to interact with Fc receptors of human monocytes and macrophages was tested by quantifying the inhibition of phagocytosis of IgG-sensitized erythrocytes. To this end a spectrometric phagocytosis test has been used. When compared with IgG for i.m. use (IgG-IM), all IgG-IV had reduced activity. This reduction was related, in part, to the reduced amount of IgG dimers and polymers in IgG-IV. On a weight basis dimeric IgG and polymeric IgG exerted 6-fold and 14-fold higher activity, respectively, than monomeric IgG. When this difference was corrected for, chemically modified IgG-IV still had significantly reduced inhibitory activity; DEAE-Sephadex-treated IgG and acid-treated IgG had an activity similar to IgG-IM, and PEG-treated IgG showed a slightly reduced activity. Pepsin-treated IgG was 〉100-fold less active than IgG-IM. The reactivity of IgG-IV with monocyte and macrophage Fc receptors was closely correlated. The most conspicuous differences found were related to the concentration at which IgG was used. Thus, β-propiolactone-treated IgG and plasmin-treated IgG were found to have significantly reduced activity at concentrations 〉20 μg/ml, but almost normal activity when used at lower concentrations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320892
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  • 6
    Digitale Medien
    Digitale Medien
    Specific and nonspecific mechanisms of action of immunoglobulin G in therapy of idiopathic thrombocytopenic purpura (ITP) (1984)
    Springer
    Annals of hematology 48 (1984), S. 345-351 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Fc receptors ; IgG infusion ; ITP, therapy of ; ITP, pathophysiology of
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The efficacy of IgG infusion therapy in ITP is now established even in cases resistant to other forms of therapy. However, the mechanism of action is still speculative. We assume that a correction of the elevated thrombocyte clearance is brought about at several levels. First, antibodies specific for an inciting antigen (and for which the patient is deficient) may remove free antigen and/or immune complexes which adhere to platelet surfaces, thereby rendering platelets less susceptible to clearance. Second, IgG may act nonspecifically by protecting the platelet surface from becoming covered with immune complexes. Third, monomeric IgG may display a nonspecific inhibitory effect at the level of the interaction of immunologically altered platelets with Fc receptors of mononuclear phagocytes. For the latter effect, good in vivo evidence exists. However, it must be born in mind that interaction of antibodies with Fc receptors is but one mechanisms for triggering adherence and endocytosis. A variety of other receptors and binding sites exists which may interact with immunologically altered thrombocytes. These may either trigger phagocytes on their own or facilitate the interaction of antibodies and Fc receptors. How IgG infusion influences such interactions remains to be determinded.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00319961
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  • 7
    Digitale Medien
    Digitale Medien
    Lack of correlation between structural features and function of synthetic agents tested for leukocyte chemotaxis (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 95-97 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary A number of proteins, poly-L-amino acids, oligopeptides and lipids were tested for neutrophil, cosinophil and macrophage chemotactic activity. One myoglobin preparation was active. Based on the negative findings for all other substances, primary structure, secondary structure, degree of hydrophobicity, size and charge of a molecule, could be ruled out as structural features recognized by chemotactically responding phagocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01936774
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