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  • 1
    Electronic Resource
    Electronic Resource
    SKIN RESISTANCE, SWEAT-GLAND COUNTS, SALIVARY FLOW, AND GASTRIC SECRETION: AGE, RACE, AND SEX DIFFERENCES, ANDINTERCORRELATIONS (1967)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 4 (1967), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Skin resistance, sweat-gland counts, salivary flow, gastric secretion, and pH were measured in volunteers and patients of both sexes, Negroes and Caucasians. Correlational analysis suggested two negatively related clusters: (A) salivary flow, sweat-gland counts, and gastric secretion; and (B) age, skin resistance, and pH. Skin resistance was higher in Negroes than Caucasians, and in females than males, increasing irregularly with age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1967.tb02759.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    PALMAR SKIN RESISTANCE AND SWEAT-GLAND COUNTS IN DRUG AND NON-DRUG STATES (1967)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 4 (1967), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Propantheline bromide, an anticholinergic blocking agent, was found to nullify all sizable changes in skin resistance. Betazole hydrochloride, a histamine isomer causing flushing of the skin, had no detectable effect on changes in skin resistance. Betazole hydrochloride did decrease the level of skin resistance, and it is possible that increased vasodilatation “pumps” more conductive (saline-like) substances into the skin. These results suggest that relatively rapid changes in skin resistance depend more upon sweat-gland activity than upon changes in the fluid content of the skin, without denying the importance of the latter. It may be that the level of skin resistance at any one time depends upon a combination of sweat-gland and vasomotor activities. Hence, as basal levels of skin resistance decrease, the relative magnitude of changes in skin resistance to stimuli also decreases (law of initial values).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1967.tb02762.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comment (1967)
    Springer
    Digestive diseases and sciences 12 (1967), S. 962-962 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02236455
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Amebic abscess of the liver (1969)
    Springer
    Digestive diseases and sciences 14 (1969), S. 290-292 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02235960
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Repeatability of gastric analysis (1973)
    Springer
    Digestive diseases and sciences 18 (1973), S. 7-13 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Repeatability of gastric analysis was evaluated by performing five tests on each of 12 subjects, using 2-hour basal and 2-hour poststimulation periods and betazole HCl as the stimulant. Coefficients of variation (CV) were calculated for each parameter of secretion (CV=SD/mean×100). Our CV's for basal secretion ranged from 26 to 49, and for stimulated secretion from 12 to 27. A review of the literature showed CV's ranging from 21 to 64 for basal secretion and 8 to 16 for stimulated secretion. A significant negative linear correlation (.01 level) was found between basal volume and CV. We concluded that gastric analysis is not as repeatable in the basal state as after stimulation and that repeatability in the basal state is partly dependent on the level of secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01072231
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  • 6
    Electronic Resource
    Electronic Resource
    Solubility of cholesterol in bile salt-lecithin model systems (1973)
    Springer
    Digestive diseases and sciences 18 (1973), S. 670-678 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cholesterol solubility was determined in model systems of unconjugated and conjugated bile salts and lecithin at physiologic concentrations. Conjugated bile salts had somewhat less dissolving power than unconjugated forms, with taurine conjugates showing less power than glycine conjugates. Lecithin increased the dissolving power of each bile salt species proportionally up to a lecithin-bile salt molar ratio of 1.0, at which point the amount of cholesterol dissolved was triple that in the absence of lecithin. At most physiologic ratios of lecithin-bile salt, however, lecithin only doubles the amount of cholesterol dissolved. Lecithin reduces, but does not eliminate, significant differences in the cholesterol dissolving power of both unconjugated and conjugated bile salt species. Mixtures of unconjugated bile salts show a simple additive effect in the absence of lecithin, but when lecithin is present the dissolving power of deoxycholate predominates over cholate, and of cholate over chenodeoxycholate. Mixtures of conjugated bile salt species produce a simple additive effect on dissolving power in both the presence and the absence of lecithin. Our cholesterol saturation curves for glycodeoxycholate and glycocholate at a total bile salt concentration of 150 mM, which we consider representative of the cholesterol dissolving power of human gallbladder bile, showed less dissolving power at lecithin-bile salt ratios of 0.25 to 0.50 than did the curve of Adminrand and Small; our curves were reasonably similar to those of Hegardt and Dam on the trilinear graph. Our studies show that changes in total bile salt concentration encountered in human gallbladder bile do produce significant shifts in the saturation curve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01072038
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  • 7
    Electronic Resource
    Electronic Resource
    Finger-tip sweat-gland activity and saliva secretion as indices of anticholinergic drug effect (1964)
    Springer
    Digestive diseases and sciences 9 (1964), S. 31-42 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A modification of Wada's finger-tip counting technic for determination of palmar sweat-gland activity is described. The active sweat-gland count of the finger tip was found to be highly reproducible under the conditions of gastric analysis. The modified sweat-gland test and Mushin's salivary-flow technic were used to study the effects of varying doses of two anticholinergic drugs during gastric analyses on 12 patients. Significant correlations were found between the initial value and the maximum drug response for both sweat- and salivary-gland tests. There also was a significant correlation between sweat- and salivary-gland activities in both the basal period and during maximum drug inhibition. The results of this study indicate that the sweat-gland test is an excellent procedure for evaluation of “side effects” of anticholinergic drugs during studies of gastric secretion. This test also is a sensitive method for determining onset of action, peak effect, and duration of action of anticholinergic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02232677
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  • 8
    Electronic Resource
    Electronic Resource
    The relative effect of an anticholinergic drug, glycopyrrolate, on basal gastric secretion and sweat- and salivary-gland activity (1967)
    Springer
    Digestive diseases and sciences 12 (1967), S. 439-448 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A finger-tip sweat-gland counting method and a salivary flow test have been used as indices of undesirable effects in a study of an injectable form of glycopyrrolate. Both tests were reliable indicators of drug effect, but the sweat-gland test was more repeatable and more sensitive than the salivary flow technic. Using these tests, glycopyrrolate in the injectable form had a significantly greater suppressive effect on basal gastric secretion than on sweating or salivary flow. The subjective symptom of dry mouth correlated well with sweat-gland activity and salivary flow. Finger-tip sweat-gland counts and salivary flow are useful objective measures of side effects in the evaluation of anticholinergic drug effect on gastric secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02233175
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Book reviews (1971)
    Springer
    Digestive diseases and sciences 16 (1971), S. 186-190 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02284462
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of sodium oleate on cholesterol solubility in bile salt-lecithin model systems (1973)
    Springer
    Digestive diseases and sciences 18 (1973), S. 1067-1074 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Reflux of pancreatic secretions and bacterial infection have been suggested as important factors in gallstone formation in some instances by introducing into bile phospholipases hydrolyzing lecithin to lysolecithin, mono- and diglycerides, and free fatty acids. Since there is little data on free fatty acids, we studied the effect of sodium oleate, the soap of one of the major fatty acid derivatives of lecithin, on cholesterol solubility in unconjugated bile salt-lecithin model solutions to see if an increase in this component might lead to saturation of bile with cholesterol. In the absence of lecithin, sodium oleate decreased cholesterol solubility in bile salt solutions at concentrations physiologic for bile, although cholesterol solubility was increased by oleate at higher oleate-bile salt ratios. In the presence of lecithin, sodium oleate decreased cholesterol solubility at all concentrations studied. Significant differences in cholesterol solubility were found for all comparable concentrations of sodium cholate and deoxycholate studied, both in the presence and absence of lecithin. Our studies showed that an increase in free fatty acid concentration can increase cholesterol saturation significantly in unconjugated bile salt-lecithin model solutions. Whether or not free fatty acid concentrations in pathologic bile reach levels sufficient to contribute to cholesterol saturation and gallstone formation cannot be determined until more adequate data on the minor lipid composition of bile becomes available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01076523
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