ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Experiments reported here were designed to investigate the effect of silibinin (extracted from Silybum marianum) on human polymorphonuclear leukocyte (PMN) motility and on leukocyte immobilizing activity of lymphokine (leukocyte inhibitory factor, LIF), formyl-Met-Leu-Phe (fMLP), calcium ionophore A-23187 and human sera inactivated by heat (HI-S). In thein vitro experiments, silibinin (1–10 μg/ml) failed to influence the random motility of unstimulated PMNS in agarose droplet assay, but enhanced the motility of the PMNs immobilized by fMLP, calcium inophore, LIF or by autologous human sera. In thein vivo study, silibinin (Legalon-70®) two hours after the administration was effective in enhancing spontaneous motility of leukocytes obtained from healthy volunteers which action could be regarded as a consequence of the decrease of leukocyte immobilizing activity being present in normal human plasma.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01966453
Permalink