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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 14 (2004), S. 0 
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: Instability of the knee joint, particularly in combination with the loss of one meniscus, regularly leads to the early development of arthritis. This paper describes the case of a 19-year-old male with ruptures of the anterior (ACL) and posterior cruciate ligament (PCL) along with the loss of the medial meniscus due to knee dislocation. Combined, time-delayed reconstruction of both the ACL and PCL and the allogenic fresh meniscal transplantation of the medial meniscus without bone plugs were performed. The control arthroscopy performed 6 months post-transplantation revealed good vitality and integration of the grafts as assessed both macroscopically and histologically. A small portion of the posterior horn had to be refixated, and the anterior horn was atrophic. At 24 months after trauma and 13 months following meniscal transplantation, the patient achieved a Lysholm score of 88 points and clinical examination indicated a stable knee. Fresh meniscal allograft transplantation, in combination with autologous ACL and PCL reconstruction, constitutes – in specialized centers – an alternative treatment option for complex trauma of the knee joint with loss of a meniscus.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 125 (1966), S. 276-293 
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wurde die Gaumensegelmuskulatur von Hund, Schwein, Rind und Pferd untersucht und mit der anderer Säugetiere und des Menschen verglichen. Dadurch konnten die bisherigen lücken- und fehlerhaften Schilderungen der Gaumensegelmuskulatur der Haussäugetiere ergänzt und ausgeglichen werden. Trotz größerer Unterschiede im Verhalten der einzelnen Muskeln ergab sich, daß die Gaumensegelmuskulatur der untersuchten Haussäugetiere einem allgemeinen Bauprinzip folgt. So besitzen auch Hund, Schwein, Rind und Pferd einen M. uvulae, dessen Ausbildung also nicht mit dem Vorhandensein oder Fehlen eines Zäpfchens im Zusammenhang steht. Der M. uvulae der Haussäugetiere ist ebenso wie alle übrigen an der Bildung der muskulösen Grundlage des Gaumensegels beteiligten Muskeln (die Mm. palatopharyngeus und levator veli palatini, der im Gaumensegel nur mit sehnigen Anteilen vertretene M. tensor veli palatini und die nur in geringem Maße mit dem Gaumensegel in Verbindung stehenden Mm. pterygopharyngeus und stylopharyngeus aboralis) paarig, wobei dieses Verhalten allerdings durch eine unterschiedlich starke Verschmelzung aufgehoben sein kann. Den vielfach beschriebenen „M. palatinus” gibt es nicht.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 136 (1972), S. 336-347 
    ISSN: 1432-0568
    Keywords: Endometrial fibroblasts ; Sheep paraplacenta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die subepithelialen Fibroblasten des Schafendometriums wandeln sich im paraplacentaren Bereich nach etwa 7 Wochen Graviditätsdauer in ein kompaktes Lager epitheloider Zellen um. Charakteristisch sind dabei die Verengung der Intercellularräume, Vermehrung von Hafteinrichtungen und Mikropinocytosevorgängen, das Auftreten von flächenhaften Membraninterdigitationen und glattem endoplasmatischem Reticulum, sowie zahlreichen, z. T. sehr großen Lysosomen und eine Vergrößerung der Golgiapparate. Gedeutet werden diese Befunde als Spezialisierung für trophische Aufgaben. Die Vorgänge erinnern ultrastrukturell an frühe Dezidualisierungsstadien von Mensch und Nagetieren.
    Notes: Summary During gravidity grow the fibroblasts of the subepitheliar paraplacental connective tissue of the sheep uterus into polyhedral, epithelium—like cells forming a distinct layer. This transformation is characterized by a narrowing of the intercellular spaces, an increase in the number of junctional specialisations and pinocytotic vesicles, the appearance of membrane interdigitations, of smooth endoplasmic reticulum, of numerous, frequently large lysosomes, and by the enlargement of the Golgi complex. The physiological significance of this transformation appears to be an improvement in the transport of substances to the fetus via the paraplacental tissue. With respect to their ultrastructural appearance, the changes resemble those of the early stages of decidua formation in man and in rodents.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1617-4623
    Keywords: Key words Antitumor ; Polyketides ; Streptomycetes ; Aureolic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A 2580-bp region of the chromosome of Streptomyces argillaceus, the producer of the antitumor polyketide mithramycin, was sequenced. Analysis of the nucleotide sequence revealed the presence of two genes (mtmGIII and mtmGIV ) encoding proteins that showed a high degree of similarity to glycosyltransferases involved in the biosynthesis of various antibiotics and antitumor drugs. Independent insertional inactivation of both genes produced mutants that did not synthesize mithramycin but accumulated several mithramycin intermediates. Both mutants accumulated premithramycinone, a non-glycosylated intermediate in mithramycin biosynthesis. The mutant affected in the mtmGIII gene also accumulated premithramycin A1, which contains premithramycinone as the aglycon unit and a D-olivose attached at C-12a-O. These experiments demonstrate that the glycosyltransferases MtmGIV and MtmGIII catalyze the first two glycosylation steps in mithramycin biosynthesis. A model is proposed for the glycosylation steps in mithramycin biosynthesis.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 59 (1920), S. 274-275 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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