Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Monoclonal Antibodies Against the Human Metalloprotease EC 3.4.24.15 Label Neurofibrillary Tangles in Alzheimer's Disease Brain (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 66 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Alzheimer's disease is characterized neuropathologically by the presence of neuritic and amyloid plaques, vascular amyloid, and neurofibrillary tangles in specific brain areas. The main constituent of amyloid deposits is amyloid β protein, a 40–42 amino acid proteolytic product of the amyloid β-precursor protein. In our search for proteases that can generate the N-terminus of amyloid β protein (β-secretases), we discovered a thiol-dependent metalloprotease that was identified, by peptide sequencing, as metalloendopeptidase EC 3.4.24.15. In vitro, the metalloprotease cleaves the methionine-aspartic acid bond in a 10 amino acid synthetic peptide, indicating that it could generate the N-terminus of amyloid β protein, and generates amyloidogenic fragments from full-length recombinant amyloid β-precursor protein. Mouse monoclonal antibodies produced against a unique synthetic peptide from the metalloprotease labeled various monkey tissues as detected by western blots and immunohistochemistry. Unexpectedly, two monoclonal antibodies, IVD6 and IIIF3, immunolabeled strongly intracellular neurofibrillary tangles, neurites of senile plaques, and neuropil threads, but not “ghost” tangles or amyloid in sections taken from Alzheimer's disease brain. This finding provides further evidence for the metalloprotease's relevance to Alzheimer's disease pathology, although the connection between tangle staining and the formation of amyloid β protein remains to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.66052011.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Ascorbic Acid in Fetal Rat Brain (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 44 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Ascorbic acid in fetal rat brain increases from 374 mg/g on the 15th day of gestation to 710 mg/g by the 20th day and remains at that level until birth. There is an 18% drop from this plateau after birth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb08804.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    I. Case of Chorionepithelioma following Vesicular Mole. (1906)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 10 (1906), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1906.tb12715.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    II. Case of Round-celled Sarcoma of the Ovary Penetrating the Uterine Wall and Presenting in the Vagina. (1906)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 10 (1906), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1906.tb12716.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Four-domain twisted nematic liquid crystal display fabricated by reverse rubbed polyimide process (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 1985-1990 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In Appl. Phys. Lett. 67, 1990 (1995), we proposed a particularly simple four-domain (4-D) twisted nematic(TN) liquid crystal display(LCD) device, which is composed of two left-handed and two right-handed TN subpixels. The two members of each pair of same handedness subpixels are rotated 180° with respect to each other, resulting in four domains that spatially average one another optically to provide a wide angle of viewing with no gray scale inversion. The optical performance of the 4-D TN LCD was confirmed by studies of a test cell fabricated by a two-step SiOx oblique evaporation technique. In this article, we report the realization of our four-domain TN display by a reverse rubbing technique that should be suitable for mass production in the display industry. The optical simulation of our 4-D TN cell was performed and the effect of disclinations at subpixel boundaries on display contrast investigated. A simple model was developed to evaluate the stability of our 4-D structure. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.363090
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Numerical investigation of the self-focusing of broad-bandwidth laser light with applied angular dispersion (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 2027-2035 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The self-focusing of phase-modulated broad-bandwidth (BBW) laser light, in which the spectral components are angularly dispersed to produce smoothing of laser nonuniformities, is analyzed. A multifrequency, multidimensional computer code has been developed to simulate the propagation of angularly dispersed BBW light within a nonlinear medium. Earlier work has shown that the self-focusing behavior of phase-modulated BBW light without angular dispersion is insignificantly different from that of monochromatic beams. With the addition of angular dispersion, pure phase modulation cannot be maintained during propagation, and the beam becomes subject to the development of spatial amplitude modulation which moves across the beam in time. Instantaneously, this amplitude modulation will begin to self-focus in a nonlinear medium. However, when examined over one period of the phase modulation, the time-integrated intensity (TII) due to the angularly dispersed BBW beam is consistently smooth, regardless of the amount of propagation modulation or self-focusing growth present in the instantaneous profile. Similarly, the angular dispersion will produce a time-dependent deflection of any amplitude modulation on the beam produced by laser defects. Because the focus of the modulation is enlarged due to the deflection, the TII of this amplitude structure is found to be less than that for a monochromatic beam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.357670
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The chemical oxidation of hydrogen-terminated silicon (111) surfaces in water studied in situ with Fourier transform infrared spectroscopy (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 8121-8127 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The chemical oxidation of hydrogen-terminated silicon (111) surfaces in water was studied in situ with Fourier transform IR spectroscopy in the multiple total internal reflection mode. On the basis of measurements of the absorbance of the Si-H and Si-O-Si vibrations as a function of time it is concluded that reactions involving the oxidation of silicon hydride and the formation of silicon oxide are coupled. The decrease in the hydride coverage and increase in the oxide coverage are linear functions of ln(t). The time dependence of oxide growth is explained in terms of electrostatic and mechanical changes at the Si/water interface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.356510
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Weak bond stretching for three orientations of Ar–HF at vHF=3 (2000)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 112 (2000), S. 7022-7031 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Three new ArHF (vHF=3) states, (3001), (3101), and (3111), have been observed between 11 350 and 11 420 cm−1 by the hot band transitions from (0001) using intracavity laser induced fluorescence. The term values and rotational constants of these levels are: (3001) ν0=11 385.928 98(28) cm−1, B=0.095 546(32) cm−1; (3101) ν0=11 444.258 12(68) cm−1, B=0.090 617(37) cm−1; and (3111) ν0=11 456.076 51(36) cm−1, B=0.091 863(14) cm−1. Observation of the ArHF (3001) state provides the van der Waals stretching frequency for ArHF at v=3, namely 46.8945(4) cm−1=(3001)–(3000). This value shows an increase of 8.208 cm−1 (21%) upon HF v=3←0 valence excitation. The stretching frequency for the T shaped ArHF is (3111)–(3110)=33.7055(5) cm−1. This value is only 7% greater than that observed at v=1. The (vHF101) Σ bend-stretch combination state, corresponding to (νs=1) of the Ar–FH configuration, has not been observed at vHF=0–2. The stretching frequency here is (3101)–(3100)=31.8178(8) cm−1. The soft-mode frequencies reveal strong bend-stretch coupling in the complex. Excellent agreement (within 0.3 cm−1) is found between experiment and prediction from Hutson's H6(4, 3, 2) potential [J. Chem. Phys. 99, 9337 (1993)], for the three new levels. Large basis set coupled cluster calculations [CCSD(T)] of the Ar–HF intermolecular potential surface, V(R,θ,r), are presented for r=0.6–2.0 Å and θ=0–180° on a grid with 15° spacing. This is an enlargement of the HF valence coordinate of more than double the equilibrium value. The dependence of the intermolecular potential upon the HF valence coordinate, r, is very anisotropic, being maximal for θ=0° and becoming essentially independent of r for θ≥45°. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.481300
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Dynamics of linear and T-shaped Ar–I2 dissociation upon B←X optical excitation: A dispersed fluorescence study of the linear isomer (1999)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 111 (1999), S. 7844-7856 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We report the dispersed fluorescence spectra of the linear and the previously well-studied T-shaped isomers of Ar–I2 following B←X optical excitation for vpump=16–26, below the I2 dissociation limit. The linear isomer has a continuum excitation spectrum. For excitation at the highest pumping energy (vpump=26), the product vibrational state distribution is nearly identical to that observed for excitation above the I2(B) dissociation limit; it shows a broad, nearly Gaussian distribution of I2(B) vibrational states, with about 22% of the available excess energy deposited in translation of the Ar+I2. This gives direct evidence that the "one-atom cage" effect seen above the I2(B) dissociation limit is attributable to the linear Ar–I2 isomer. The product vibrational state distribution becomes increasingly Poisson for decreasing excitation energies, and only about 7% of the excess energy is deposited in translation for vpump=16. The bond energy in the linear isomer is determined from the spectra, 170(±1.5)≤D0″(linear Ar–I2(X))≤174(±1.5) cm−1. A bond energy of D0″(T-shaped Ar–I2(X))=142±15 cm−1 is estimated based on the linear to T-shaped population ratio observed in the beam, which is about 90 cm−1 smaller than that determined from fluorescence spectra. We suggest that electronic quenching in the T-shaped isomer is nearly 100% for the highest vibrational level produced by vibrational predissociation. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.480120
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    THE CONTINUOUS MEASUREMENT OF TISSUE pH IN THE HUMAN FETUS DURING LABOUR USING A NEW APPLICATION TECHNIQUE (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The subcutaneous tissue pH (tpH) of 61 fetuses has been measured continuously during labour using the tissue pH electrode designed by Stamm (Stamm et al, 1976) and adapted for use by Roche Medical and Laboratory Systems. These 61 fetuses fell chronologically into two groups: Group 1 comprised 31 fetuses in whom the original method of fixation to the fetal scalp was used, and Group 2 comprised 30 fetuses in whom the fixation apparatus incorporated the latest technical developments of the double spiral electrocardiograph (ECG) electrode and the fetal tpH Applicator Tool Set Model 678449. Better results were obtained with Model 678449.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04598.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...