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  • 1
    Electronic Resource
    Electronic Resource
    Stabilization of Streptomyces lividans by Homologous Recombinational Insertion (1992)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 10 (1992), S. 570-573 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed a system for the introduction and maintenance of novel tandem repeats in the chromosome of Streptomyces lividans 66. This was achieved by introducing, via transformation, Escherichia coli “suicide” vectors carrying manipulated S. lividans DNA fragments. Selection for ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0592-570
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  • 2
    Electronic Resource
    Electronic Resource
    Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 413 (2001), S. 316-322 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is expressed near the G1–S phase transition and is thought to be critical for the initiation of DNA replication and other S-phase functions. Accumulation of cyclin E at the G1–S boundary ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35095076
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  • 3
    Electronic Resource
    Electronic Resource
    Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast (2003)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 423 (2003), S. 1009-1013 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Cks proteins are small evolutionarily conserved proteins that interact genetically and physically with cyclin-dependent kinases. However, in spite of a large body of genetic, biochemical and structural research, no compelling unifying model of their functions has emerged. Here we show, by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01720
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  • 4
    Electronic Resource
    Electronic Resource
    Histologische untersuchungen über die corpora allata und prothoraxdrüsen der lepidopteren in bezug auf ihre funktion (1949)
    Springer
    Development genes and evolution 144 (1949), S. 99-131 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00575297
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  • 5
    Electronic Resource
    Electronic Resource
    Molecular studies in 37 Silver-Russell syndrome patients: frequency and etiology of uniparental disomy (1997)
    Springer
    Human genetics 〈Berlin〉 100 (1997), S. 415-419 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We report studies on the etiology of uniparental disomy (UPD) in Silver-Russell syndrome (SRS) patients. Thirty-seven SRS families were typed with short tandem repeat markers from chromosomes 2, 7, 9, 14, and 16. UPD for these chromosomes has either been described in association with growth retardation or has been observed in confined placental mosaicism, a mechanism that may result in UPD. Maternal UPD7 was detected in three SRS patients, accounting for approximately 10% of the tested SRS patients. These results agree with previously published studies. The allelic distribution in one of the three families indicates complete isodisomy, whereas allelic patterns in the other two families are consistent with partial and complete heterodisomy, respectively, suggesting that, in the latter cases, UPD originates from maternal meiosis, whereas in the first case, it seems to be of mitotic origin. STR typing for UPD of chromosomes 2, 9, 14, and 16 showed no abnormalities. Our results demonstrate the necessity of screening SRS patients for UPD7, although the effect of UPD7 cannot be correlated with the SRS phenotype as yet. An association between UPD for the other investigated chromosomes and SRS seems to be negligible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050526
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  • 6
    Electronic Resource
    Electronic Resource
    Pericentric inversions (1984)
    Springer
    Human genetics 〈Berlin〉 68 (1984), S. 1-47 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A review is given of the incidence, cytogenetics, and biologic relevance of pericentric inversions (pii). In 251 cases in the literature and our patients, 96 different inversion forms with different breakpoints are found. Eighteen of these cases have been observed several times in unrelated families; they are classified as types. The problem of pii in the heterochromatic regions of chromosomes 1 and 9 is especially emphasized and the investigations required are pointed out. The significance of the individual pii is checked with regard to their behavior in meiosis and their phenotypical relevance. An approximately 1:1 segregation is found. Fertility, stillbirth, and rates of abortion are not statistically altered. The gonadal findings available at present in man are reported and commented on. The occurrence of aneusomic recombinants among the live offspring of carriers shows a marked dependence on the length of the relative inversion segments. Since these are distinctly below average in inversion types, they only result in recombinants in exceptional cases. Certain pointers to an above-random common occurrence of other chromosomal aberrations are not found in families with pii. A correlation between pii and clinical symptoms like-wise cannot be detected. However, in this connection it is pointed out that trisomic mosaics were observed jointly with pii (9) and pii (22). The review is completed by a brief examination of the literature concerning the significance of pii in evolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293869
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  • 7
    Electronic Resource
    Electronic Resource
    Cytogenetic and molecular characterization of a newly established neuroblastoma cell line LS (1991)
    Springer
    Human genetics 〈Berlin〉 86 (1991), S. 562-566 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new human neuroblastoma cell line (LS) that originated from an abdominal tumor of a 16-month-old girl is presented; it was classified, according to Evans, as being stage III. Morphological (dense-core particles) and biochemical characteristics (dopamine-β-hydroxylase, acetylcholinesterase, neuron-specific-enolase) confirmed the diagnosis. In addition to a slightly variable modal chromosome number of 48 or 49 (because of marker-chromosomes and autosomal trisomies), cytogenetic analysis revealed two constantly appearing chromosomes with homogeneously stained regions (HSR's). The karyo-type remained constant over 50 passages in vitro [49,XX, −12,+der5, + 17,+mar1,+mar2]. Double minutes were a rare phenomenon and appeared only in a few metaphases. In situ hybridization showed that some of the HSR's consisted of amplified N-myc copies. The distribution of the N-myc copies according to in situ hybridization signals along the HSR's was compared with the data of Southern and Northern blotting analyses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201542
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  • 8
    Electronic Resource
    Electronic Resource
    Die Inkretorgane der Termiten im Kastendifferenzierungsgeschehen (1955)
    Springer
    Naturwissenschaften 42 (1955), S. 303-304 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00608948
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  • 9
    Electronic Resource
    Electronic Resource
    „Mißt” die Köcherfliegenlarve Hydropsyche angustipennis Curt. beim Bau des Netzes die Maschenweite? (1962)
    Springer
    Naturwissenschaften 49 (1962), S. 116-116 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00632001
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  • 10
    Electronic Resource
    Electronic Resource
    Muscle metabolism during intense, heavy-resistance exercise (1986)
    Springer
    European journal of applied physiology 55 (1986), S. 362-366 
    Details
    ISSN: 1439-6327
    Keywords: ATP, CP, glucose ; Glucose-6-phosphate ; Lactate ; Glycogen ; α-glycerophosphoate ; Strength training
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The objective of this study was to examine the muscle metabolic changes occurring during intense and prolonged, heavy-resistance exercise. Muscle biopsies were obtained from the vastus lateralis of 9 strength trained athletes before and 30 s after an exercise regimen comprising 5 sets each of front squats, back squats, leg presses and knee extensions using barbell or variable resistance machines. Each set was executed until muscle failure, which occurred within 6–12 muscle contractions. The exercise: rest ratio was approximately 1∶2 and the total performance time was 30 min. Concentrations of adenosine triphosphate (ATP), creatine phosphate (CP), creatine, glycogen, glucose, glucose-6-phosphate (G-6-P), α-glycerophosphate (α-G-P) and lactate were determined on freeze-dried tissue samples using fluorometric assays. Blood samples were analyzed for lactate and glucose. The exercise produced significant reductions in ATP (p〈0.01) and CP (p〈0.001), while α-G-P more than doubled (p〈0.05), glucose increased tenfold (p〈0.001) and G-6-P fourfold (p〈0.001). Muscle lactate concentration at cessation of exercise averaged 17.3 mmol · kg−1 w.w. Glycogen concentration decreased (p〈0.001) from 160 to 118 mmol · kg−1 w. w. It is concluded that high intensity, heavy resistance exercise is associated with a high rate of energy utilization through phosphagen breakdown and activation of glycogenolysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422734
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