ISSN:
1432-1912
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 1. Amblystoma punctatum embryos and larvae were exposed at various developmental stages to D.F.P. concentrations ranging from 10−5 to 10−10 M. 2. D.F.P. is lethal in concentrations from 10−9 M on to pre-motile embryos shown not to contain cholinesterase. 3. D.F.P. causes convulsions, paralysis and death of free-swimming larvae, and, in concentrations known to inhibit acetylcholinesterase (“true” cholinesterase) in vitro, inhibits it also in larvae. 4. The survival time of larvae exposed to D.F.P. depends on D.F.P. concentration rather than on acetylcholinesterase inhibition. 5. There is a considerable degree of functional recovery of D.F.P.-treated larvae upon transfer to spring water, not accompanied by reappearance of acetylcholinesterase. 6. Pentobarbital sodium premedication or treatment prevent or arrest D.F.P. convulsions but do not prolong life. 7. Atropine does not prevent or stop D.F.P. convulsions, but prolongs life of larvae treated with D.F.P. concentrations weaker than 10−5 M. Atropine did not prevent strychnine convulsions. 8. These D.F.P. effects on premotile Amblystoma embryos and freeswimming larvae, and on acetylcholinesterase activity of the latter, and the effects of atropine on D.F.P. toxicity, are discussed with special emphasis on possible “cholinesterasic” and “non-cholinesterasic” components of D.F.P. action.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00246299
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