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  • 1
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: The relationship between various stressful stimulus conditions, measures of anxiety, and altered esophageal motility was investigated in mo experiments employing normal adult volunteers. In Experiment 1, subjects were administered separately I00dB continuous white noise and a cold pressor task. In Experiment 2. subjects were administered in a counterbalanced order intermittent and unpredictable bursts of 100dB white noise and a cognitive task consisting of solvable and unsolvable discrimination problems. Results of both experiments showed that the amplitudes of peristaltic esophageal contractions and levels of state anxiety self-reports were significantly higher during periods of stress than during preceding baseline periods. Furthermore, in Experiment 2, esophageal contraction velocities and anxiety-related behaviors were significantly greater during stress periods than during baselines. Contrary' to previous studies, few abnormal tertiary esophageal contractions were elicited by stress. The present results identify increased amplitude of the peristaltic contractions as the primary esophageal response to stress. Technological and methodological differences between this study and previous Investigations of affective disturbance among patients with chronic esophageal chest pain also are examined.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2568
    Keywords: esophagitis ; sucralfate ; prostaglandin ; cytoprotection ; acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cytoprotective effects of liquid sucralfate and a synthetic analog of prostaglandin E1 (PGE1) on acid-induced esophagitis in cats were studied. Esophagitis was induced in adult cats using a constant infusion of 0.1 N HCl at 1 ml/min for 20 min. Animals were infused for either one or three days. Mucosal lesions were evaluated by blinded investigators using both fiberoptic endoscopy and light microscopy. Histologic changes included basal cell hyperplasia, intraepithelial leukocytosis, and subepithelial leukocytosis. Liquid sucralfate given prior to acid infusion consistently prevented acid-induced lesions in both one- and three-day infusions, demonstrated by both endoscopy and quantitative histologic scoring. Indomethacin (200 μg/kg) given prior to sucralfate and acid did not affect sucralfate cytoprotection. Synthetic PGE1, given in doses of 5 μg/kg and 100 μg/kg, afforded no esophageal cytoprotection. These studies indicate that sucralfate is cytoprotective against acid-induced esophageal injury in cats, an effect that does not appear to be mediated by prostaglandin. In addition, synthetic PGE1 does not confer protection in this animal model.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 43 (1998), S. 1973-1977 
    ISSN: 1573-2568
    Keywords: PNEUMATIC DILATATION ; ACHALASIA ; ESOPHAGUS ; ESOPHAGEAL MOTILITY DISORDERS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although pneumatic dilatation (PD) has been anestablished treatment for achalasia for decades, thereis limited information on its long-term clinicalefficacy. We have followed up the clinical status of patients having PD with a 30- or 35-mm balloonby one of us (D.O.C.) over a 25-year period. Of 144patients whose initial records were available forreview, 31 could not be contacted. Of the remaining 113 patients, 72 (64%) responded to a questionnaireassessing swallowing status and patient satisfaction,and this forms the basis of this report. There were 32men and 40 women, with mean age 46 years (range: 17-78); mean length of follow-up since PD was6.5 years (range: 10 months to 25 years). Success wasprimarily defined by the need for no additional therapyfor achalasia other than one or two PD's. PD was effective long-term treatment in 61/72 patients(85% ); only four of these required a second PD overthis time interval. There was no significant differencein any of the following parameters between patients with a treatment success or failure: age, sex,size of pneumatic dilator, and duration of symptomsprior to PD. Response was significantly better (P 〈0.05) in patients having no prior dilatation (43/47; 91%) than in those in whom another physicianhad performed prior dilatation (18/25; 72%). In responseto the question of whether they would select PD again,68 patients (94%) responded positively. In conclusion, pneumatic dilatation performedusing a consistent technique by an experienced physicianis effective long-term therapy for achalasia patients ofall ages. Most patients require only onedilatation.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 45 (2000), S. 2182-2182 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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