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  • 1
    Electronic Resource
    Electronic Resource
    In vitro cytotoxicity of antimicrobial agents to human keratinocytes (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 6 (1996), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Backround The degree of bacterial contamination in the wound bed plays a key role in determining the level of “take” of keratinoeyte grafts in burn patients. This study was done to evaluate the best suited antimicrobial agent for topical application in relation to antimicrobial activity and cytotoxic effect on graft cells.Objective The cytotoxicity of 7 antibacterial agents (gentamicin sulphate, ciprofloxacin hydrochioride, bacitracin, polymyxin B sulphate, diethanolamin salt of fusidic acid, teicoplanin, vancomycin hydrochtoride), one anlifungal substance (amphotcricin B sodium deoxycholate) and one antiseptic agent (povidone iodine) on cultured human keratinocytes, HaCaT keratinocytes and fibroblasts was investigated.Material and methods The effects of these agents were tested using two separate assays - the neutral red assay and the Bradford protein assay. In order to assess toxicity of the agent, the obtained midpoint cytotoxicity (MC50) was compared to the respective minimal inhibitory concentration (MIC) for receiving the cytotoxic potential in microbiologically effective doses.Results Antibiotics effective against Staphylococcus aureus with a small potential of toxicity are Bacitracin, Fusidic acid, Vancomycin and Tcicoplanin. Gentamicin and Ciprofloxacin are effective against both Staphylococcus aureus and Pseudomonas aeruginosa with a low potential of toxicity.Conclusion The use of antimicrobial agents with a midpoint cytotoxicity (MC50) higher than the minimal inhibitory concentration (MIC) by at least a factor of 100 might reduce the risk of toxic injury to graft cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1996.tb00160.x
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  • 2
    Electronic Resource
    Electronic Resource
    Direct profilometry of the skin: its reproducibility and variability (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 5 (1995), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective The degree of reproducibility and precision of the mechanical direct profilometry and the intra- and interindividual fluctuations of 7 surface parameters were investigated.Material and methods Negative replicas were sampled from defined areas of the skin of 31 volunteers an evaluated with the profile-tracking device TKC 300 Hommeltester in order to derive data about the inter- and intraindividual fluctuations. To determine the precision of this method 6 roughness parameters and J of waviness of each replica were repetitively evaluated. The practicability was tested introducing minimal changes in the experimental set-up. Further, the effect of urea-containing creme on the skins topography was investigated in a double-blind clinical setting on a collective of 11 patients.Results The precision of this method is shown by nearly unchanged topographic parameters. Moreover, our data show smaller intra- than interindividual fluctuations of roughness (Ra) and waviness (Wt), being an important demand for clinical investigations.Conclusion In this paper we demonstrate that the parameters of both roughness as well as the recently introduced waviness can be conveniently evaluated with a high degree of precision with the direct profilometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1995.tb00428.x
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  • 3
    Electronic Resource
    Electronic Resource
    DIAGNOSIS AT FIRST GLANCE: THE BABOON SYNDROME (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 35 (1996), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1996.tb01667.x
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  • 4
    Electronic Resource
    Electronic Resource
    Intra- and interindividual variations of direct profilometry of different skin areas (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 8 (1997), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1997.tb00460.x
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  • 5
    Electronic Resource
    Electronic Resource
    Multiple kutane Neoplasien bei Cyclosporin-Therapie nach Nierentransplantation (1995)
    Springer
    Der Hautarzt 46 (1995), S. 638-642 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Cyclosporin A ; Immunsuppression ; Kutane Neoplasien ; Key words Cyclosporin A ; Immunosuppression - Cutaneous neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report on a 56-year-old renal allograft recipient receiving cyclosporin A immunosuppression. During this therapy he subsequently developed the following cutaneous neoplasms: squamous cell carcinomas, basal cell carcinomas, Bowen's disease, actinic keratosis, sebaceous hyperplasia, a dysplastic naevus and, finally a nodular malignant melanoma. Adverse effects of the cyclosporin A therapy are discussed, with special reference to dermatologic effects and the implications for patient and doctor.
    Notes: Zusammenfassung Wir berichten über einen 56jährigen Patienten, der unter Cyclosporin-Behandlung aufgrund einer Nierentransplantation multiple kutane Neoplasien entwickelte. Zu diesen Tumoren, die operativ entfernt wurden, zählten spinozelluläre Karzinome, Basaliome, M. Bowen, aktinische Keratosen, Talgdrüsenhyperplasien, ein dysplastischer Nävus und zuletzt ein noduläres malignes Melanom. In Anlehnung an diese Kasuistik wird die Cyclosporin-Therapie in Hinsicht auf Konsequenzen für Arzt und Patient unter besonderer Berücksichtigung der dermatologischen Seite diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050311
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  • 6
    Electronic Resource
    Electronic Resource
    Einfluß einmaliger UVA- und UVB-Bestrahlung auf Oberflächenbeschaffenheit und viskoelastische Eigenschaften der Haut in vivo (1996)
    Springer
    Der Hautarzt 47 (1996), S. 515-520 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter UV-Einfluß ; Hautoberflächenbeschaffenheit ; Viskoelastische Eigenschaften ; Profilometrie ; Cutometrie ; Key words UV irradiation ; Skin surface structure ; Viscoelastic properties ; Profilometry ; Cutometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The present study was designed to evaluate the effects of single irradiation either with UVA (dosage: 50 J/cm2) or UVB (dosage: 1MED) on surface structure and viscoelastic properties of human skin. Biophysical measurements by means of profilometry and cutometry were carried out on normally sunprotected skin areas directly before and 24 hours after irradiation. UVA induced neither measurable changes in skin surface structure (expressed by the profilometrically calculated parameters of roughness Ra and RzDIN and the parameter Wt reflecting depths of furrows) nor in its viscoelastic properties (expressed by the cutometrically calculated ratio Uv/Ue reflecting viscosity and the ratio Ur/Uf reflecting biological elasticity). However, a single erythemogenic dose of UVB radiation was followed by significant increase in the depths of furrows, increase in viscosity and decrease in biological elasticity.
    Notes: Zusammenfassung Ziel der vorliegenden Untersuchungen war die Beantwortung der Frage, ob jeweils definiert dosierte, einmalige UVA- und einmalige, erythemauslösende UVB-Bestrahlung quantitativ meßbare Veränderungen relevanter klinischer Parameter menschlicher Haut wie Oberflächenstruktur und viskoelastische Eigenschaften bewirken könnten. Mittels der biophysikalischen Meßmethoden Profilometrie und Cutometrie erfolgten dazu Untersuchungen an nicht sonnenexponierter Haut direkt vor und 24 h nach UVA-Bestrahlung (Dosis: 50 J/cm 2 ) bzw. UVBBestrahlung (Dosis: 1 MED (minimale Erythemdosis)). Insgesamt sprechen unsere Resultate dafür, daß einmalige UVA-Bestrahlung in der oben erwähnten Dosisgrößenordnung keine meßbaren Veränderungen der Oberflächenbeschaffenheit (ausgedrückt durch die profilometrisch kalkulierten Parameter Ra und RzDIN für die Rauhigkeit bzw. Wt für die Faltentiefe) und viskoelastischen Eigenschaften der Haut (ausgedrückt durch die cutometrisch ermittelten Rationes Uv/Ue für die Viskosität bzw. Ur/Uf für die biologische Elastizität) bewirkt. Einmalige erythemauslösende UVB-Bestrahlung führt ebenfalls nicht zu Rauhigkeitsveränderungen, jedoch zu einer quantifizierbaren Erhöhung der Faltentiefe und der Viskosität und einer Verminderung der biologischen Elastizität der Haut.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050462
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