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  • 1
    Electronic Resource
    Electronic Resource
    Isoform-Specific Redistribution of Calcineurin Aα and Aβ in the Hippocampal CA1 Region of Gerbils After Transient Ischemia (1998)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 70 (1998), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: To investigate isoform-specific roles of Ca2+/calmodulin-dependent phosphatase [calcineurin (CaN)] in ischemia-induced cell death, we raised antibodies specific to CaN Aα and CaN Aβ and localized the CaN isoforms in the hippocampal CA1 region of Mongolian gerbils subjected to a 5-min occlusion of carotid arteries. In the nonischemic gerbil, immunoreactions of both isoforms were highly enriched in CA1 regions, especially in the cytoplasm and apical dendrites of CA1 pyramidal neurons. At 4–7 days after the induced ischemia, immunoreactivities of the CaN Aα isoform in CA1 pyramidal cells were markedly reduced, whereas they were enhanced in the CA1 radiatum and oriens layers. In contrast, CaN Aβ immunoreactivities were reduced in all layers of the ischemic CA1 region, whereas they were enhanced in activated astrocytes, colocalizing with glial fibrillary acidic protein. These findings suggest that up-regulation of CaN Aα in afferent fibers in CA1 and up-regulation of CaN Aβ in reactive astrocytes may be involved in neuronal reorganization after ischemic injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1998.70031289.x
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  • 2
    Electronic Resource
    Electronic Resource
    Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 628-634 
    Details
    ISSN: 1432-0533
    Keywords: Intercellular adhesion molecule-1 ; Leukocyte function-associated antigen-1 ; Astrocytes ; Microglia ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intercellular adhesion molecule-1 (ICAM-1) was localized immunohistochemically in postmortem brain tissue of Alzheimer's disease (AD), progressive supranuclear palsy, amyotrophic lateral sclerosis, Pick's disease, and controls. In controls, only capillaries were stained for ICAM-1. In affected areas of neurologically disease brains, a subset of reactive astrocytes was also strongly stained. In addition, there were irregular, diffuse patches of positive staining in the tissue matrix. In AD, many of these patches had dense cores which corresponded with senile plaques. Double immunostaining for glial fibrillary acidic protein and ICAM-1 indicated that some reactive astrocytes at the periphery of senile plaques were positive for ICAM-1. Within such plaques, microglial aggregates were stained intensely for leukocyte function-associated antigen-1 (LFA-1), the adhesion molecule for ICAM-1. The LFA-1/ICAM-1 system appears to play an important role in the interaction of astrocytes and microglia in several neurological diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334673
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  • 3
    Electronic Resource
    Electronic Resource
    Age-related decrease of nerve growth factor-like immunoreactivity in the basal forebrain of senescence-accelerated mice (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 11-16 
    Details
    ISSN: 1432-0533
    Keywords: Nerve growth factor ; Senescence-accelerated mouse ; Basal forebrain ; Brain atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The senescence-acceleratedmouse P10 (SAMP10) is a murine model of accelerated senescence characterized by the deterioration of learning and memory with advancing age. In the present study, we examined the distribution of nerve growth factor (NGF) immunohistochemically in SAMP10 mice and its control strain, SAMR1. In both strains, NGF-like immunoreactivity (NGF-IR) was observed in neurons throughout the entire forebrain and in glial cells in a particular location. In aged SAMP10 mice, each layer of the cerebral cortex retained its NGF-IR, although the thickness of the cortical mantle was markedly decreased in comparison with younger animals. There was an age-related decline in NGF-IR in the substantia innominata of SAMP10 mice at the age of 10 months, when compared to 2-month-old SAMP10. These results indicate age-related decrease of NGF in the basal forebrain in SAMP10 mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294454
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  • 4
    Electronic Resource
    Electronic Resource
    Monoamine oxidase-B-positive granular structures in the hippocampus of aged senescence-accelerated mouse (SAMP8) (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 626-632 
    Details
    ISSN: 1432-0533
    Keywords: Monoamine oxidase-B ; Senescence-accelerated mouse (SAM) ; Monoamine oxidase-B-positive granular structure ; Periodic acid-Schiff-positive granular structure ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the histochemical localization of monoamine oxidase in the hippocampus of young and old senescence-accelerated mouse (SAM). We found a monoamine oxidase-B-positive granular structure (MGS) in the hippocampus of old SAMP8, an accelerated senescenceprone line of SAM. The MGS was a round-shaped granular structure of 0.5 to 5 μm diameter and usually formed a cluster, the largest diameter of which ranged from 50 to 150 μm. No MGS were found in the hippocampus of young SAMP8 or of young SAMR1, an accelerated senescence resistant line of SAM, and only few, if any, were seen in old SAMR1. A monoamine oxidase-positive astrocyte was usually observed in the central area of each cluster of MGS. Furthermore, the MGS was in close anatomical relationship with monoamine oxidase-positive astrocytic processes. The enzyme inhibition experiments showed that monoamine oxidase activities localized in the MGS and astrocytes were both predominantly of type B. These findings suggest MGS occurs at least partly in monoamine oxidase-B-positive astrocytes. Furthermore, the MGS was similar to a periodic acid-Schiff-positive granular structure, a polyglucosan body previously documented in the brains of old SAMP8 and some other aged mice strains including C57BL/6 and nude mice, in terms of their size, morphological appearances and topographical distribution in the hippocampus. Thus, the present results suggest that monoamine oxidase type B is a proteinaceous component of the periodic acid-Schiff-positive granular structure in aged mice brains, and might provide some clues for clarifying the mechanisms of age-related occurrence of periodic acid-Schiff-positive granular structures in mice brains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318576
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  • 5
    Electronic Resource
    Electronic Resource
    Monoamine oxidase-B-positive granular structures in the hippocampus of aged senescence-accelerated mouse (SAMP8) (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 626-632 
    Details
    ISSN: 1432-0533
    Keywords: Key words Monoamine oxidase-B ; Senescence-accelerated mouse (SAM) ; Monoamine ; oxidase-B-positive granular structure ; Periodic ; acid-Schiff-positive granular structure ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the histochemical localization of monoamine oxidase in the hippocampus of young and old senescence-accelerated mouse (SAM). We found a monoamine oxidase-B-positive granular structure (MGS) in the hippocampus of old SAMP8, an accelerated senescence-prone line of SAM. The MGS was a round-shaped granular structure of 0.5 to 5 μm diameter and usually formed a cluster, the largest diameter of which ranged from 50 to 150 μm. No MGS were found in the hippocampus of young SAMP8 or of young SAMR1, an accelerated senescence resistant line of SAM, and only few, if any, were seen in old SAMR1. A monoamine oxidase-positive astrocyte was usually observed in the central area of each cluster of MGS. Furthermore, the MGS was in close anatomical relationship with monoamine oxidase-positive astrocytic processes. The enzyme inhibition experiments showed that monoamine oxidase activities localized in the MGS and astrocytes were both predominantly of type B. These findings suggest MGS occurs at least partly in monoamine oxidase-B-positive astrocytes. Furthermore, the MGS was similar to a periodic acid-Schiff-positive granular structure, a polyglucosan body previously documented in the brains of old SAMP8 and some other aged mice strains including C57BL/6 and nude mice, in terms of their size, morphological appearances and topographical distribution in the hippocampus. Thus, the present results suggest that monoamine oxidase type B is a proteinaceous component of the periodic acid-Schiff-positive granular structure in aged mice brains, and might provide some clues for clarifying the mechanisms of age-related occurrence of periodic acid-Schiff-positive granular structures in mice brains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318576
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  • 6
    Electronic Resource
    Electronic Resource
    Age-related decrease of nerve growth factor-like immunoreactivity in the basal forebrain of senescence-accelerated mice (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 11-16 
    Details
    ISSN: 1432-0533
    Keywords: Key words Nerve growth factor ; Senescence-accelerated mouse ; Basal forebrain ; Brain atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The senescence-accelerated mouse P10 (SAMP10) is a murine model of accelerated senescence characterized by the deterioration of learning and memory with advancing age. In the present study, we examined the distribution of nerve growth factor (NGF) immunohistochemically in SAMP10 mice and its control strain, SAMR1. In both strains, NGF-like immunoreactivity (NGF-IR) was observed in neurons throughout the entire forebrain and in glial cells in a particular location. In aged SAMP10 mice, each layer of the cerebral cortex retained its NGF-IR, although the thickness of the cortical mantle was markedly decreased in comparison with younger animals. There was an age-related decline in NGF-IR in the substantia innominata of SAMP10 mice at the age of 10 months, when compared to 2-month-old SAMP10. These results indicate age-related decrease of NGF in the basal forebrain in SAMP10 mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294454
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  • 7
    Electronic Resource
    Electronic Resource
    Catalytic action of metallic salts in autoxidation and polymerization. IV. Polymerization of methyl methacrylate by cobalt(II) or (III) acetylacetonate-tert-butyl hydroperoxide or dioxane hydroperoxide (1970)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 8 (1970), S. 2957-2969 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Polymerization of methyl methacrylate was carried out by four initiating systems, namely, cobalt(II) or (III) acetylacetonate-tert-butyl hydroperoxide (t-Bu HPO) or dioxane hydroperoxide (DOX HPO). Dioxane hydroperoxide systems were much more effective for the polymerization of methyl methacrylate than tert-butyl hydroperoxide systems, and cobaltous acetylacetonate was more effective than cobaltic acetylacetonate in both hydroperoxides. The initiating activity order and activation energy for the polymerization were as follows: Co(acac)2-DOX HPO (Ea-9.3 kcal/mole) 〉 Co (acac)3-DOX HPO (Ea = 12.4 kcal/mole) 〉 Co(acac)2-t-Bu HPO (Ea = 15.1 kcal/mole) 〉 Co(acac)3-t-Bu HPO (Ea-18.5 kcal/mole). The effects of conversion and hydroperoxide concentration on the degree of polymerization were also examined. The kinetic data on the decomposition of hydroperoxides catalyzed by cobalt salts gave a little information for the interpretation of polymerization process.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1970.150081020
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  • 8
    Electronic Resource
    Electronic Resource
    Catalytic action of metallic salts in autoxidation and polymerization. VIII. Polymerization of methyl methacrylate by various metal acetylacetonate-cyclic ether hydroperoxides (1972)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 10 (1972), S. 1491-1498 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Polymerization of methyl methacrylate by cyclic ether hydroperoxide-metal acetylacetonate systems for a number of different metals was carried out to compare with the tert-butyl hydroperoxide-metal acetylacetonate initiating systems. The rate of polymerization of methyl methacrylate with cyclic ether hydroperoxides as initiating systems was much higher than that with tert-butyl hydroperoxide. In cyclic ether hydroperoxide initiating systems, V(III), Co(II,III), Fe(III), Cu(II), and Mn(II) promoted the polymerization rate markedly, and Zn(II), Ni(II), Al(III), and Mg(II) had little or no effect; in the tert-butyl hydroperoxide initiating system only V(III), Co(II), and Mn(II) enhanced polymerization rate, and most of other metals showed little or no effect. Furthermore, noticeable differences in color of solution and appearance during polymerization, and in relation between conversion and the degree of polymerization were observed. The effect of metal acetylacetonates on hydroperoxide initiators in polymerization of methyl methacrylate was also compared with that on the decomposition of hydroperoxides.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1972.150100517
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