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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 40 (1975), S. 3529-3536 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 15 (1982), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Immunofluorcscent and esterase staining of Peyer's patch (PP) cell preparations from six mouse strains showed that each strain possessed approximately eqtial numbers of T and B cells but less than 1% esterase-positive cells (macrophages; Mψ). The addition of concanavalin A (Con A) to either lipopolysaccharide (LPS)-responsive C3H/HeN or LPS-non-responsive C3H/Hej PP cultures immunized with sheep erythrocytes (SRBC) resulted in good anti-SRBC plaque-forming cell responses, whereas the addition of Con A to PP cultures from SRBC orally primed C3H/HeJ mice resulted in significantly higher in vitro responses to trinitrophenyl-conjugated SRBC than similarly treated cultures from C3H/HeN mice. On the other hand, muramyl dipeptide (MDP) promoted higher responses in PP cultures derived from either normal or carrier-primed LPS-rcsponsive (C3H/HeN) mice than were observed with C3H/HeJ PP cultures. A similar pattern of responsiveness was seen when LPS prepared by a phenol-water extraction procedure (LPS(Ph)) was added to PP cultures. When LPS prepared by a bntanol-water extraction method was used, PP cultures from both C3H/HeN and C3H/HeJ mice were enhanced; however, the response of C3H/HeN PP cultures was significantly greater than that seen with C3H/HeJ PP cultures. The enhanced responsiveness of C3H/HeN PP cultures to MDP was probably due to an effect on the Mψ, since addition of MDP to either C3H/HeN or C3H/HeJ PP cultures containing C3H/HeN splenic adherent cells resulted in significantly enhanced immune responses. C3H/HeJ splenic Mψ did not promote adjuvant responses. LPS(Ph) augmentation of immune responses required that Mψ (spleen) and PP cultures be derived from LPS-re-sponsive C3H/HeN mice. These results demonstrated that Con A, MDP, and LPS promoted immune responses of PP cultures to the T-dependent antigen, SRBC. Evidence is presented that Con A enhanced T-helper-cell activity, whereas MDP and LPS required the presence of LPS-responsive Mψ for augmentation of immune responses.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of medicine & science in sports 2 (1992), S. 0 
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The purpose of this study was to determine resting serum erythropoietin concentrations (S-[epo]) in endurance-trained sea-level residents 2 week after arrival at moderate altitude as well as after descent to sea level, and in endurance- and strength-trained residents at moderate altitude. S-[epo] concentrations were determined in 2 groups of non-altitude-acclimatized endurance-trained athletes normally living at sea level (group UAET, 20 men and 7 women, and group UACCS, 14 men and 6 women); and 2 groups of altitude-acclimatized athletes, all long-term residents at 1900 m above sea level (strength-trained judo athletes, group AST 10 men and 11 women, and endurance-trained athletes, group AET, 10 men and 10 women). Hematocrit (Hct) but not S-[ep] was significantly higher in pup AET than group AST Resting S-[epo] in group UAET was determined l,2,7, and 14 d after arrival from sea level to 1900 m above sea level. The Hct increased significantly from day 1 to day 7 in the women of group UAET. The Hct of the males in group UAET did not change significantly throughout the 2 weeks at altitude. The women in group UAET showed a significant decrease in S-[epo] from day 1 to day 7, The S-[epo] in the men of group UAET did not change from day 1 to day 2, but decreased significantly from day 2 to day 14. Resting S-[epo] in group UACCS was obtained before and at the end of the 2-week training period at high-altitude and after high-altitude training. Only the UACCS men had, in comparison with sea-level S-[epo], similar S-[epo] after 2 weeks of high-altitude training and significantly lower S-[epo] 2 d, but not 9 or 19 d after descent to sea level. These data indicate similar resting S-[epo] levels in acclimatized endurance- and strength-trained athletes, although the former group had higher Hct than the latter. In non-altitude-acclimatized endurance athletes, S-[epo] increased the ht days at altitude and thereafter decreased to similar S-[epo] as at sea level after 2 weeks of altitude training. After descent to sea level, S-[epo] decreased transiently but returned to the pre-altitude level after 9 d
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 4 (1995), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Leg ulcers present a common and recurring problem in older people creating discomfort and distress for the patient and a great cost to the health care services. Cultured keratinocyte grafts have been used by many investigators to stimulate healing of chronic venous ulcers. It has been proposed that they may do this by producing cytokines which modulate the healing process. However, the types and levels of cytokines in the leg ulcer fluid before and during healing arc not known. Wound fluid was collected from venous leg ulcers in 18 patients beneath occlusive Tega-derm™ dressing for 4 to 6 h. The leg ulcers were divided on clinical criteria into ‘healing’ and ‘non-healing’. PDGF-AB, GM-CSE IL-1α, IL-1β. IL-6 and bFGF were measured by ELISA and the levels of IL-1α, IL-1β. and IL-6 were also measured using biological assays. The effect of leg ulcer wound fluid on fibroblast and keratinocyte proliferation was measured indirectly by 3H-thymidine incorporation and MTT assay. Total protein, albumin levels, fibronectin degrading activity and collagenase activity, both active and latent were measured. No statistically significant differences in the levels of cytokines or collagenase were identified between healing and non-healing leg ulcers in the sample of leg ulcers studied. However, this study does give valuable information concerning the levels of cytokines and collagenase in chronic leg ulcer wound fluid.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 52 (1980), S. 0 
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 4 (1995), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract This investigation was conducted when previously rcpealable experimental data became impossible to reproduce when using keratino-cytes cultured in serum-free medium. Differences in calcium molarity between batches of medium were identified as a source of variation in cultured keratinocyte populations. The susceptibility of cultured keralinocytes to even small alterations in calcium molarily has been demonstrated. 2 regular medium batches were compared with a special preparation of medium, devoid of calcium chloride then supplemented with a known concentration of calcium ions. Culture progress in each medium was assessed by: morphological observation, % cells expressing involucrin and proliferating cell nuclear antigen, cell attachment, growth rate and colony forming efficiency. In order to control the phenotype of cultured kera-tinocytes, in a rcpoducible system, it is recommended that serum-free keratinocyte medium is purchased with the omission of calcium chloride. Supplementation of this medium may then be made by the investigator to suit individual culture requirements.
    Type of Medium: Electronic Resource
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  • 7
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    London : Periodicals Archive Online (PAO)
    Journal of adolescence. 9:3 (1986:Sept.) 243 
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 119 (1988), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Adolescence 9 (1986), S. 243-256 
    ISSN: 0140-1971
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 10
    facet.materialart.
    Unknown
    Johannesburg : Periodicals Archive Online (PAO)
    English studies in Africa. 30:1 (1987) 17 
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