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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 29 (1977), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 22 (1974), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The spontaneous efflux of [3H]GABA and its metabolites from the frog retina has been studied. The efflux of radioactivity was multiphasic in the presence or absence of amino-oxyacetic acid (AOAA), an inhibitor of GABA metabolism, and was not affected by light or dark adaptation.Strong retention of radioactivity was evident in the presence of AOAA, about 90% of the label remaining in the tissue after 4 h superfusion. Under these conditions, increases in the rate of release of radioactivity were evoked by electrical stimulation, 40 mm-potassium. unlabelled GABA (5 mm), ouabain (5 × 10−5m) and the absence of calcium. The amount of [3H]GABA released by electrical stimulation was not markedly calcium dependent, whereas the response to 40 mm-potassium was reduced by 96% in the absence of calcium.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The uptake of L-[3H]DABA by rat cerebral cortex slices was studied. Analysis of the kinetic data obtained provides evidence that DABA entry is mediated by both high and low affinity carriers. When cortical slices were incubated in the presence of equimolar [3H]DABA and [14C]GABA the ratio of entry of the two radionuclides was found to depend upon the loading concentration. The specificity of the uptake of 1 μM and 1 mM-L-DABA was examined: GABA and DABA were relatively potent inhibitors of 1 μM-DABA uptake whereas an equal concentration of histidine did not produce significant inhibition. In contrast, DABA and histidine were markedly more potent as inhibitors of 1 mM-DABA uptake than was GABA. It is concluded from these experiments that L-DABA is transported into cortical slices by a carrier which has high affinities for both DABA and GABA and by a second lower affinity carrier which prefers DABA as a substrate to GABA. On the basis of a comparison of the effects of inhibitors on [3H]DABA and [3H]GABA uptake it is estimated that approx 26% of DABA uptake at 1 μM does not occur by the high affinity carrier whereas at 1 mM-DABA this proportion rises to 62–67%.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Taurine is taken up into the frog retina by active, sodium dependent, temperature sensitive systems that show both high and low affinity for the amino acid (Kmabout 50 μm and 2 mm respectively). Autoradiographs from retinae incubated in radioactively labelled taurine showed heavy grain density over cell bodies in the position of amacrine interneurones and over specific strata in the inner synaptic layer of the tissue. Photoreceptor cells were also labelled.Taurine, once accumulated by the frog retina, is not lost during the incubation and is only slowly metabolised. Electrical stimulation caused taurine release above the level of spontaneous efflux but light or depolarisation of the tissue with 40mm-potassium chloride did not.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 171 (1953), S. 927-928 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The character of the creep of the copper wires when tested under 730 kgm.cm.-2 at 258C. depended strongly on the previous anneal time. The instantaneous extension increases, and the creep-rate at any chosen time decreases, with increase in the time of anneal. Detailed discussion of this is outside ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 207 (1965), S. 1086-1087 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Single crystals of aluminium spark-machined to the specimen shape discussed by Andrade7 were stressed in a thermostatic enclosure at 1.80 C by means of an hydraulic device. The experimental assembly enables the static and the alternating components of stress to be controlled and monitored ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 195 (1962), S. 898-899 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Creep and creep recovery have been investigated with the equipment over ranges of stress and temperature. In Fig. 1, the continuous curves (which are accurately reproducible) represent the creep under a constant torque of 7-9 x 103 lb./in.2 at the temperatures indicated. Similar sets of curves for ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 175 (1955), S. 674-676 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN a very large number of practical applications, metals are subjected to discontinuous stress and temperature conditions. These arise, for example, in gas turbines, where certain of the components are stressed during the running period at a fairly high temperature, and afterwards cool down and ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 178 (1956), S. 810-811 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A low-level sinusoidal fatigue stress (of about 300 c./s.) superimposed on the static creep stress increases the creep-rate of lead markedly. This phenomenon has already been observed by Greenwood1. In the present case, the measurements show that this increase is considerably greater than that ...
    Type of Medium: Electronic Resource
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