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  • 1
    Electronic Resource
    Electronic Resource
    A comparative study of Fas and Fas-ligand expression during melanoma progression (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Impaired regulation of apoptosis is known to be associated with the development of various cancers. Fas receptor (APO-1/CD95) binding to its ligand, Fas-ligand (Fas-L), has been shown to trigger apoptosis in various cell types.  Objectives In this study, we examined CD95 and Fas-L expression on primary and metastatic melanoma cells from patients to investigate a potential correlation between these measures of apoptosis and different disease stages.  Patients and methods Primary melanoma cells were obtained after surgical resection from 19 patients and metastatic cells from fine-needle aspiration of lymph nodes or palpable subcutaneous lesions in 25 patients. Normal skin cells were obtained at skin biopsy of 10 healthy donors.  Results Flow cytometric analysis revealed that CD95 and Fas-L expression was detected in all the kinds of cell studied. In whole cell suspensions, CD95 expression was significantly higher (P 〈 0·0001) in normal skin cells than in melanoma cells, whatever the stage studied. By contrast, we observed an increase in Fas-L expression in melanoma cells compared with normal ones. Subsequently, using a double staining method, we studied these measures on HMB45+ cells, a specific marker for melanoma cells, and found that CD95 expression was significantly higher (P = 0·0005) in primary than in metastatic cells while Fas-L expression was significantly increased (P = 0·0004) in metastatic compared with primary cells. Furthermore, a relationship was found between CD95 or Fas-L expression and Breslow thickness; as primary melanoma thickness progressively increased, the percentage of HMB45+ CD95+ cells decreased while that of HMB45+ Fas-L+ cells concurrently increased.  Conclusions These results suggest that downregulation of CD95 and upregulation of Fas-L in melanoma might be considered as concomitant with disease progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03655.x
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  • 2
    Electronic Resource
    Electronic Resource
    Role of Infection in the Modulation of Mouse Circulating Soluble Cell-Free Fcγ2b/γ1 Receptor (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 24 (1986), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have recently demonstrated the occurrence of functional circulating soluble cell-free Fcγ2b/γ1 receptor in normal mouse serum by means of the 2.4G2 rat monoclonal antibody. With the solid phase radioimmunoassay described previously, we report here a dramatic increase in the level of circulating soluble cell-free Fcγ2b/γ1 in Schistosoma mansoni- infected mice individually tested before and on days 22, 41, 62, and 82 after infection. This increase was statistically highly significant when the five measurements from each mouse were compared, and also when the entire group of infected mice was compared with the stable level of Cf- Fcγ2b/γ1R measured in strain-, sex-, and age-matched control mice individually tested on the same days. This increase was commensurate with a rise in the amount of IgG detected in the sera of the S. mansoni-infected mice. Thus, infection seems to be one of the factors that modulate the expression of such soluble Cf-Fcγ2b/γ1R in mouse serum. Furthermore, the experimental device reported here for the production of high levels of Cf- Fcγ2b/γ1R by infection (in this case by parasitic infection) could serve as a model for obtaining large quantities of serum Cf- Fcγ2b/γ1R for further purification. Lastly, we point out that, by establishing a functional relationship with circulating IgG, such soluble Cf- Fcγ2b/γ1R may modulate some of the functions in which the Fc portion of immunoglobulins is involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1986.tb02072.x
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  • 3
    Electronic Resource
    Electronic Resource
    Flow cytometry analysis of F-actin in TPA treated keratinocytes labeled by rhodamine phalloidin
    Amsterdam : Elsevier
    Biology of the Cell 76 (1992), S. 242 
    Details
    ISSN: 0248-4900
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0248-4900(92)90308-N
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  • 4
    Electronic Resource
    Electronic Resource
    European School of Oncology European consensus on the use of granulocyte colony-stimulating factor: the example of breast cancer (1996)
    Springer
    Cancer chemotherapy and pharmacology 38 (1996), S. S103 
    Details
    ISSN: 1432-0843
    Keywords: Key words Granulocyte growth factors ; Breast cancer ; Dose intensification ; Peripheral blood stem cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  An apparent chemotherapeutic dose-response relationship for patients with breast cancer has provided clinicians with the impetus to investigate further the usefulness of dose-intensification strategies in this setting. These approaches have provided promising results: noticeable improvements in response rates in terms of disease-free survival have been recorded, particularly when dose intensification has been used as first-line consolidation therapy for chemosensitive advanced disease and as consolidation in adjuvant therapy for high-risk patients. It may also be of use in the treatment of inflammatory and locally advanced disease. Although the results of prospective studies will help to define the potential advantages of dose-intensification strategies further, comparisons of myeloablative and subablative intensification regimens are needed to define the role of dose and dose intensity in this setting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800051049
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  • 5
    Electronic Resource
    Electronic Resource
    Phase I study of Datelliptium chloride, hydrochloride given by 24-h continuous intravenous infusion (1992)
    Springer
    Cancer chemotherapy and pharmacology 30 (1992), S. 226-228 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Datelliptium chloride, hydrochloride (SR 95 156B, NSC 626718X, DHE) was studied in a phase I trial of escalating doses given on a single 24-h continuous intravenous infusion schedule. Doses were escalated from 40 to 500 mg/m2 in 19 patients who received a total of 24 courses. Courses were repeated after a minimal interval of 3 weeks. Local venous toxicity occurred at low doses (≤100 mg/m2) and was circumvented by the use of a central venous access for higher doses. Other clinical adverse events occurred (≥330 mg/m2), including moderate nausea and vomiting, mild diarrhea, dry mouth, neuropsychiatric manifestations, and fatigue. All of these side effects were reversible and none was dose-limiting. The dose-limiting toxicity was related to hepatic laboratory-test abnormalities in the form of reversible elevations of levels of serum bilirubin and liver enzymes at doses of ≥330 mg/m2. The maximum tolerated dose for this schedule is 500 mg/m2. Hematologic toxicity was minimal and non-dose-limiting. Neither drug-related deaths nor objective complete or partial responses were observed. However, a minor response and a long-term disease stabilization were obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686318
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  • 6
    Electronic Resource
    Electronic Resource
    Prospective study of the potentiation of acenocoumarol by amiodarone (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 625-629 
    Details
    ISSN: 1432-1041
    Keywords: amiodarone ; acenocoumarol ; antivitamin K ; drug interaction ; prothrombin activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of oral amiodarone on the anticoagulant effect of the coumarine derivative acenocoumarol has been investigated prospectively in 10 patients with normal renal, hepatic and haematological function and who were not in cardiac failure. The daily dose of acenocoumarol was sufficient to produce a prothrombin activity of 25 to 35%. When the prothrombin time had become stable amiodarone 600 mg/d was administered for 1 week followed by 400 mg/d for the next 3 weeks. A decrease in prothrombin activity from 30.5 to 20.2% was observed, associated with a decrease in vitamin K coagulation factors, after a mean of 4 days following commencement of amiodarone. In 6 patients a prothrombin activity 〈20% required a 60% reduction in the dose of acenocoumarol after 1 week of amiodarone 600 mg, and a 33% reduction after 3 weeks of amiodarone 400 mg. There was no correlation between the plasma amiodarone and the decrease in prothrombin activity. Inhibition of acenocoumarol metabolism by amiodarone is the most likely explanation of these findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607905
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  • 7
    Electronic Resource
    Electronic Resource
    The effects of diltiazem on methotrexate-induced nephrotoxicity (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 337-340 
    Details
    ISSN: 1432-1041
    Keywords: diltiazem ; methotrexate ; calcium antagonists ; nephrotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have tested the effects of calcium channel blockade with diltiazem on methotrexate-induced nephrotoxicity in patients with biopsy-proven malignant disease. The patients were randomized in a cross-over fashion to receive MTX (4 g · m−2 body surface area) with or without Diltiazem (360 mg per day orally) during two consecutive periods separated by a 3-week interval. Methotrexate caused reversible acute renal failure, with an increase in serum creatinine from 89 (7)µmol·1−1 on day 0 to 150 (6)µmol.·1−1 on Day 6. The patterns of β2-microglobulin and N-acetyl glucosaminidase urinary excretion were similar, with a sharp increase from Day 0 to Day 3. Urinary β2-microglobulin excretion increased from 161 (57) µg·1−1 on Day 0 to 1160 (840) µg·l−1 on Day 3 and fell to 918 (530) µg·l−1 on Day 10. Urinary Nacetyl glucosaminidase excretion increased from 250 (100) mmol·h−1 per mg of creatinine on Day 0 up to 655 (261) on Day 3 and fell to 285 (82) on Day 10. The evolution of renal function was not influenced by diltiazem. In patients receiving diltiazem, serum creatinine increased from 93 (0) µmol·l−1 on Day 0 to 151 (68) µmol·l−1 on Day 6 (p = NS when compared with control values). Urinary enzyme excretion also markedly increased from Day 0 to Day 3 to the same extent as in the group not receiving diltiazem. Our data indicate that acute deterioration in renal function caused by methotrexate is accompanied by tubular damage. Diltiazem was ineffective in preventing the acute renal failure induced by methotrexate. An inadequate dosage of diltiazem or multifactorial toxic effects of methotrexate may account for this negative result.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558496
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  • 8
    Electronic Resource
    Electronic Resource
    The clinical measurement of volumes using helical CT (1996)
    Springer
    Surgical and radiologic anatomy 18 (1996), S. 227-231 
    Details
    ISSN: 1279-8517
    Keywords: Volume ; Helical CT ; Clinical oncology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cette étude préliminaire a pour objet d'évaluer les nouvelles techniques de mesure par examen TDM hélicoïdal permettant l'évaluation directe du volume d'une lésion, notamment par corrélation anatomique macroscopique en pratique clinique. L'application première est anatomique avec la mesure du volume d'organes ou de structures anatomiques; son intérêt clinique concerne avant tout la cancérologie. Nous présentons les premiers résultats, leurs applications et limites avant d'élargir cette étude à une plus grande série et dans le but qu'elle soit confrontée à d'autres évaluations multicentriques.
    Notes: Summary The object of this preliminary study is to evaluate the new techniques of measurement by helical CT which allow direct assessment of the volume of a lesion in clinical practice particularly by obtaining direct macroscopic anatomical correlation. Its primary application is anatomical, with measurement of the volumes of organs or anatomical structures, the clinical importance of which relates primarily to oncology. We present our initial results, including their applications and limits, before extending this study to a larger series so that it may be compared with other multicentre evaluations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346131
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  • 9
    Electronic Resource
    Electronic Resource
    Virtual tracheo-bronchial endoscopy: educational and diagnostic value (1996)
    Springer
    Surgical and radiologic anatomy 18 (1996), S. 125-131 
    Details
    ISSN: 1279-8517
    Keywords: Helical CT ; Virtual endoscopic image ; Tracheo-bronchial tree
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'acquisition hélicoïdale en scanner apporte une amélioration significative de la qualité des examens dans de nombreuses indications. Elle est particulièrement adaptée, grâce à des modes nouveaux de traitement d'image (protocole de Recherche GEMS), à l'étude de l'arbre respiratoire, par l'obtention d'images endoscopiques virtuelles, ne nécessitant aucune sonde endoscopique. Nous en présentons les premières confrontations anatomo-radiologiques et leur intérêt pédagogique ainsi qu'une réflexion sur les éventuelles perspectives d'applications cliniques.
    Notes: Summary The use of Helical CT significantly improves image quality of examinations in a number of clinical settings. It is particularly suited to the study of the tracheo-bronchial tree as a result of new ways of image processing (developed by GEMS research) which can produce virtual endoscopic images without the use of an endoscope. We present our initial anatamo-radiological findings and their educational value as well as our thoughts on potential future clinical applications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01795231
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  • 10
    Electronic Resource
    Electronic Resource
    A double-blind, randomised, parallel study comparing intravenous dolasetron plus dexamethasone and intravenous dolasetron alone for the management of fractionated cisplatin-related nausea and vomiting (2000)
    Springer
    Supportive care in cancer 8 (2000), S. 49-54 
    Details
    ISSN: 1433-7339
    Keywords: Key words Nausea ; Emesis ; Vomiting ; Emetogenicity ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Fractionated cisplatin-containing regimens are routinely used for chemotherapy in certain types of cancer. Dolasetron has been shown to be effective in preventing acute emesis related to high-dose cisplatin chemotherapy over 24 h; its effectiveness has not been evaluated in fractionated cisplatin-containing chemotherapy. This trial was designed to assess the efficacy of dolasetron alone or dolasetron plus dexamethasone in preventing nausea and vomiting related to fractionated cisplatin chemotherapy. The patients were 210 cancer in-patients, who were randomised to receive 100 mg dolasetron i.v. or 100 mg dolasetron i.v. plus 20 mg dexamethasone before chemotherapy primarily with cisplatin (15–50 mg/m2) infused over ≤4 h for at least 2 but not more than 5 consecutive days. Dolasetron was administered to all patients 30 min before cisplatin. Dexamethasone was administered in double-blind fashion 5 min before cisplatin. Efficacy was measured at hour 24 of each study day using complete response (no vomiting and no rescue medication) and maximum severity of nausea, self-assessed by patients using a 100-mm visual analogue scale. Most (198) of the patients completed the study and were evaluable. Overall complete response rates were significantly higher in the dolasetron plus dexamethasone group than in the dolasetron only group (72.9% vs 40.8%, respectively; P〈0.0001). Complete response rates on each study day were also significantly higher with dolasetron plus dexamethasone than with dolasetron alone (P〈0.029), with an attenuated efficacy in the delayed phase in both groups. Chi-square test and logistic regression applied to daily response rates indicated a significant influence of treatment (day 1: P=0.0002, day 2: P〈0.0001, day 3: P=0.0007, day 4: P=0. 0007, day 5: P=0.029). Treatment and duration of chemotherapy exerted the only statistically significant subgroup effects on complete response (P〈0.0001). Both treatments were administered safely. As seen with other 5-HT3 receptor antagonist antiemetics, the addition of dexamethasone to dolasetron significantly increases effectiveness in preventing nausea and vomiting related to fractionated cisplatin chemotherapy. Both dolasetron and dolasetron plus dexamethasone were well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005209900090
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