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  • 1
    Digitale Medien
    Digitale Medien
    Induced agglutinability of 3T3 mouse fibroblasts (1975)
    [s.l.] : Nature Publishing Group
    Nature 254 (1975), S. 247-248 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Py3T3 and 3T3 cells were cultured on plastic substrate at 37 C, pH 7.0, in Dulbecco's modification of Eagle's MEM, supplemented with 10% foetal calf serum and antibiotics (Grand Island Biological Co.). Preliminary experiments showed that agglutination by con A was a function of time, pH, con A ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/254247a0
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  • 2
    Digitale Medien
    Digitale Medien
    Isolation of immunogenic tumour cells by cell-affinity chromatography (1976)
    [s.l.] : Nature Publishing Group
    Nature 259 (1976), S. 674-676 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] We now report that highly immunogenic cells can be isolated from the parental tumour cell population by cell-affinity chromatography with concanavalin A (con A). Immunisation with these cells after chemotherapy resulted in complete remission of LI210 leukaemia. L1210 cells (Arthur D. Little Co.) ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/259674a0
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  • 3
    Digitale Medien
    Digitale Medien
    Tumorigenicity and the expression of cell-surface carbohydrates (1976)
    [s.l.] : Nature Publishing Group
    Nature 261 (1976), S. 54-56 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The transplantable mammary adenocarcinoma A-10 (syngeneic to strain A/J mice) has been maintained as an ascitic tumour in B6AF1 (C57BL/6A/J) mice, and in monolayer culture using RPMI 1640 medium, supplemented with 10% foetal calf serum and antibiotics. The tumorigenicity of A-10 cells grown in ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/261054a0
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  • 4
    Digitale Medien
    Digitale Medien
    Autoreactive factors identify tumor-host heterogeneity and responsiveness to immunotherapy (1982)
    Springer
    Cancer immunology immunotherapy 12 (1982), S. 111-117 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The heterogeneity of tumor-bearing animals was defined by the presence of an autoreactive antibody and cell agglutination factor in the sera of leukemic mice. The presence of this antibody, which could only be detected by its ability to lyse neuraminidase-treated spleen cells, correlated directly with the survival of the animals treated with active, specific immunotherapy. The results indicate that heterogeneity in hosts can be identified, and that autoreactive factors may be predictive for the individual response to immunotherapy and play a role in the establishment of the tumor-host relationship.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00205368
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  • 5
    Digitale Medien
    Digitale Medien
    Evaluation of time and dose in treating mammary adenocarcinoma with immunostimulants (1977)
    Springer
    Cancer immunology immunotherapy 2 (1977), S. 63-68 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary BCG, C. parvum, and reovirus were used as immunostimulants in treating murine mammary adenocarcinoma (A-10) after tumor burden had been minimized with BCNU. Immunostimulants were administered at different times with respect to chemotherapy. Different doses were used to determine the optimal response as measured by survival. BCG induced the best response when 6.67×105 organisms were given 2 days after chemotherapy. The optimal response with C. parvum was observed after a dose of 0.35 mg was given 1 or 2 days after chemotherapy. Similarly, reovirus produced the best response when 1010 plaque-forming units were given 2 days after chemotherapy. These data are consistent with previous findings and support the notion that immunostimulants require an appropriate lymphoid substrate in order to induce an adequate anti-tumor response.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00199092
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  • 6
    Digitale Medien
    Digitale Medien
    Histologic evaluation of L1210 leukemia in treated and untreated mice (1977)
    Springer
    Cancer immunology immunotherapy 2 (1977), S. 57-62 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary BDF1 mice bearing L1210 leukemia were treated with chemotherapy or in combination with neuraminidase-treated cells and BCG. Histological evaluation was done on these mice at various intervals after therapy in order to determine the rate and extent of metastatic involvement in various tissues and organs. Results were compared to tumor-bearing mice which were not treated. In all animals, tissues were classed as having minimal involvement, moderate involvement or maximal involvement based on a scale of 0 through 4. Results indicated that: (a) mice which were long term survivors did not completely reject their tumor for weeks after treatment with chemotherapy and immunotherapy; (b) complete tumor rejection did not indicate a restoration of normal tissue integrity; and (c) failure of chemotherapy-immunotherapy had no consistent pathology, but was probably due to tumor distribution rather then tumor burden per se.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00199091
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  • 7
    Digitale Medien
    Digitale Medien
    In situ activation of mouse macrophages and therapy of spontaneous renal cell cancer metastasis by liposomes containing the lipopeptide CGP 31362 (1991)
    Springer
    Cancer immunology immunotherapy 33 (1991), S. 375-381 
    Details
    ISSN: 1432-0851
    Schlagwort(e): Mouse macrophages ; Renal cell cancer ; Metastasis ; Liposomes ; CGP 31 362
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We determined whether the intravenous administration of multilamellar vesicle liposomes (MLV) containing a lipopeptide analogue of a fragment from the cell wall of gram-negative bacteria (CGP 31 362) can render BALB/c mouse alveolar macrophages tumoricidal in situ and reduce the incidence of spontaneous lung metastasis of syngeneic renal carcinoma (RENCA) cells. Alveolar macrophages (a) incubated in vitro with MLV containing CGP 31 362 (MLV-31 362) and (b) harvested from mice injected i.v. with MLV-31 362 were rendered cytotoxic against the RENCA cells. Maximum cytotoxic activity of the macrophages was induced by injecting 5 µmol MLV consisting of 250 mg phospholipids and 0.5 mg CGP 31 362. The single i.v. injection of 5 µmol MLV-31 362 produced activation of macrophages that lasted for up to 4 days. Repeated i. v. injections of MLV-31 362 produced a continuous antitumor activity in alveolar macrophages. To study the lipopeptide's effects on metastasis, we injected the left kidneys of BALB/c mice with RENCA cells. The kidney with growing tumor was resected 10 days later and, after a further 2 days, groups of mice were injected i.v. with MLV-31 362 or with MLV-HBSS (twice weekly for 3 weeks). Treatment with MLV-31 362 significantly decreased the median number of spontaneous lung metastases. These data demonstrate that the systemic administration of MLV-31 362 can activate murine lung macrophages in situ and reduce the incidence of spontaneous RENCA lung metastases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01741597
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  • 8
    Digitale Medien
    Digitale Medien
    The immunogenic properties of drug-resistant murine tumor cells do not correlate with expression of the MDR phenotype (1993)
    Springer
    Cancer immunology immunotherapy 36 (1993), S. 381-386 
    Details
    ISSN: 1432-0851
    Schlagwort(e): P-glycoprotein ; MDR phenotype ; Immunogenicity ; Drug resistance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Alterations in the immunogenic properties of tumor cells frequently accompany selection for multipledrug-resistant (MDR) variants. Therefore, studies were performed to examine the hypothesis that overexpression of membrane P-glycoprotein, commonly observed in MDR tumor cells, is associated with enhanced immunogenic properties. Immunogenicity was determined by (a) the ability of drug-sensitive parental UV2237M fibrosarcoma cells and drug-resistant UV2237M variant cells to immunize normal mice against rechallenge with parental tumor cells and (b) the ability of normal syngeneic mice to reject cell inocula that caused progressive tumor growth in immunocompromised mice. Variant UV2237M cell lines included subpopulations selected for a six- to ten-fold increase in mRNA for P-glycoprotein and expression of the MDR phenotype (resistance to doxorubicin) and cells sensitive to doxorubicin (and no expression of MDR properties) but resistant to ouabain. All UV2237M drug-resistant cells were highly immunogenic in immunocompetent mice, regardless of their MDR phenotype. Additional studies showed that CT-26 murine adenocarcinoma cells, sensitive or resistant to doxorubicin (expressing high levels of P-glycoprotein), injected into normal syngeneic Balb/c mice produced rapidly growing tumors. The data do not demonstrate a correlation between the immunogenic properties of drug-resistant tumor cells and the expression of P-glycoprotein.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01742254
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  • 9
    Digitale Medien
    Digitale Medien
    Immunotherapy with tumor cell subpopulations (1978)
    Springer
    Cancer immunology immunotherapy 4 (1978), S. 115-119 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary L1210 tumor subpopulations were isolated by lectin-nylon chromatography and evaluated in active, specific immunotherapy of residual L1210 leukemia (following reduction in tumor burden by chemotherapy). Immunotherapy with cells either not binding mannosylspecific columns or eluted from fucose-specific columns resulted in a higher percent of long-term survivors compared to mice treated with chemotherapy only. In contrast, immunotherapy with cells eluted from galactose-specific columns was deleterious, and abrogated the beneficial effects of chemotherapy. The results emphasize that (a) clinical immunotherapy may be either beneficial or deleterious, depending upon the properties of the tumor cell vaccine, and (b) the therapeutic value of L1210 subpopulations is related to the expression of cell-surface carbohydrates.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00200112
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  • 10
    Digitale Medien
    Digitale Medien
    The immunotherapeutic value of a L1210 tumor cell vaccine depends upon the expression of cell-surface carbohydrates (1977)
    Springer
    Cancer immunology immunotherapy 3 (1977), S. 87-91 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Active, specific immunotherapy of L1210 leukemia (following reduction in tumor burden by chemotherapy) with an L1210 tumor cell subpopulation (con A-Fraction A) depended upon the integrity of cell-surface constituents. The immunotherapeutic value of con A-Fraction A cells was abrogated by treatment of the cells with either neuraminidase or galactosidase, and mice treated with these cells died faster than mice treated with chemotherapy alone. Glucosidase and protease treatment totally destroyed the immunogenicity of the tumor cell vaccine. The results suggest that the immunogenic properties of this vaccine may reside in the cell-surface expression of glycoprotein.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00200063
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