ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Thermosensitive scaffold was suggested for the partial replacement of nucleus indegenerated intervertebral disc with a minimally invasive surgical procedure. Biocompatible andthermosensitive scaffolds were prepared by coupling reaction of Pluronic with chitosan and it wasinserted in degenerative spinal motion segments. To confirm the regeneration of degenerative discsand subsequent structural stability, cell proliferation and morphological changes were evaluatedusing relaxation time, quantity of DNA and histological examination. As a result, inserted groupshowed higher relaxation time, reduced the decrement of DNA contents, and accumulated GAGamount. The results confirmed the potential of thermosensitive scaffolds and minimally invasivesurgical procedure for the regeneration of degenerative discs
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.397.pdf
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