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  • 1
    Electronic Resource
    Electronic Resource
    Dopamine, serotonin and alpha-adrenergic receptor blocking activities in serum and their relationships to prolactin level in schizophrenic patients receiving long-term chlorpromazine treatment (1983)
    Springer
    Psychopharmacology 79 (1983), S. 266-270 
    Details
    ISSN: 1432-2072
    Keywords: Radioreceptor assays ; Serum receptor blocking activities ; Prolactin ; Chlorpromazine ; Chronic schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical application of a dopamine radioreceptor assay for neuroleptics has been proposed. Simultaneous monitoring of serum antidopaminergic (anti-DA), antiserotonergic (anti-5 HT) antiadrenergic (anti-NA) activities may provide a better understanding of clinical effects of neuroleptics. Serum anti-DA and anti-5 HT activities were estimated by competition for 3H-spiperone binding to dopamine and serotonin receptors in rat brain, respectively, and anti-NA activity by competition for 3H-WB-4101 binding to alphareceptors. Thirty-one patients receiving maintenance doses of chlorpromazine (CPZ) chronically were studied. Serum activitics varied among patients receiving the same dose, but correlated significantly with dose. Anti-DA activity also correlated with both anti-5 HT anti-NA activities, and the average ratio of anti-5 HT or anti-NA to anti-DA activity was slightly reduced by metabolism of CPZ. However, some patients had a different spectrum of serum activities from that of in vitro activities. Serum prolactin (PRL) correlated weakly with all the serum activities. The serum PRL anti-DA activity ratio appeared to be independent of anti-5 HT or anti-NA activity, suggesting the predominant involvement of anti-DA activity in the stimulation of PRL release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427825
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Optimization of Welding Conditions for Sealing of Lithium-Ion Battery by Pulsed Nd:YAG Laser (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 580-582 (June 2008), p. 523-526 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Laser material processing is a very rapidly advancing technology for various industrialapplications, because of its many advantages. A few of its major advantages, less yet bettercontrolled heat input, have been successfully exploited for the very critical application of aluminumalloy welding. This study suggested the source of weld-defects and its solution methods in weldinga lithium ion battery with pulsed Nd:YAG laser. In the experiment, battery case has changed overjoint geometry from side welding to flat welding. In the case of an electrolyte inlet seal welding,welding was carried out after pressing an Al ball and the degree of eccentricity, the contact lengthand the gap are presented as major parameters. With the Al ball indent improvement, theeccentricity and the gap were reduced and the contact length was increased. As a result of anexperiment, a sound weld bead shape and crack-free weld bead were obtained
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/18/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.580-582.523.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Quantitative determination and regional distribution of pipecolic acid in rodent brain (1984)
    Springer
    Neurochemical research 9 (1984), S. 1559-1569 
    Details
    ISSN: 1573-6903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A rapid and sensitive method for the quantitative determination of pipecolic acid (PA), one of the three cyclic secondary imino acids present in mammalian brain is described. The quantification and identification of PA are accomplished in rat and mouse brain using high performance liquid chromatography with electrochemical detection (LCEC) and nipecotic acid (NPA) as an internal standard. The cyclic imino acids are derivatized with 2,4-dinitrofluorobenzene (DNFB) to dinitrophenyl derivatives. The remaining time for LCEC analysis is less than 30 min and the limit of sensitivity is in the lower picomole range. The levels of PA found in rat and mouse brain are comparable to those reported using gas chromatography/mass spectrometry. The regional distribution of PA shows higher concentrations of PA in hypothalamus, pons-medulla oblongata and cerebellum. The present results demonstrate that LCEC is sensitive enough to determine endogenous levels of PA in mg amounts of rodent brain tissue. Due to its simplicity and rapidity, the technique represents an alternative to existing methods. This method can also be used for determination of PA in CSF, blood or urine of hyperipecolic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964591
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  • 4
    Electronic Resource
    Electronic Resource
    Transport of pipecolic acid in adult and developing mouse brain (1985)
    Springer
    Neurochemical research 10 (1985), S. 1405-1415 
    Details
    ISSN: 1573-6903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration ofd,l-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentration peaks at 5–10 min (40 nmol/g). The level remains relatively stable up to 5 hrs and then declines slowly to 24 hrs. In serum, the level of PA increases rapidly to reach the maximum value at 10 min and then decreases rapidly in the first hour and continues to decline more slowly to 24 hrs. The net uptake of PA following administration of various amounts ofd,l-PA is saturable at low doses (3.9–15.6 mg/kg), and it increases linearly at higher doses in a dose-dependent manner up to the maximum dose (500 mg/kg) used in the present study. Kinetic analysis suggests the presence of two kinds of transport systems. These findings are in good agreement with the previous results usingd,l-[3H]PA in the mouse (7) andl-[14C]PA in the rat (13). There were no significant differences between uptake ofd-pipecolic acid andl-pipecolic acid (250 mg/kg, i. p., 10 min), suggesting the absence of stereospecificity for PA uptake in the mouse brain. Developmental changes in net brain uptake of PA following injections ofd,l-PA (250 mg/kg, s.c., 10 min) showed an age-dependent decrease which continues until adult levels are reached at four weeks after birth. The results suggest that the blood brain barrier (BBB) for PA is completed during the first month of life. Following administration ofd,l-PA (250 mg/kg, s.c.) to pregnant mice during the period 19–21 days of gestation, PA level increases in fetal brain to a maximum value at 2 hrs (420 nmol/g). This level is unchanged during 24 hrs. The maximum level of PA in fetal serum is reached at 30 min to 1 hr. The level gradually decreases after 1 hr over 24 hrs. These results indicate that PA taken up by the placenta and into the brain is transported from the fetal circulation. Our results also demonstrate that a higher amount of PA is taken up by the fetal than the adult brain. This finding is important in order to develop an animal model of hyperpipecolatemia in which high brain levels of PA should mimick those of human hyperpipecolatemic patients. Our results strongly support the hypothesis that high levels of PA present in brain during fetal life may exert a devastating effect on the development of the human CNS in hyperpipecolatemic children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964981
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