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  • 1
    Electronic Resource
    Electronic Resource
    Assessment of the normal adult right ventricular diastolic function using M-mode echocardiographic measurement of tricuspid ring motion (1998)
    Springer
    The international journal of cardiovascular imaging 14 (1998), S. 391-395 
    Details
    ISSN: 1573-0743
    Keywords: M-mode echocardiography ; right ventricular diastolic function ; tricuspid ring motion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Right ventricular function can be evaluated echocardiographically by assessing the longitudinal motion of the tricuspid ring recorded in the apical four chamber view. In this study, we applied this technique to assess the right ventricular diastolic function in 10 healthy Japanese men (mean age : 28±6 years; age range : 20–43 years). Echocardiographic studies were performed with a phased-array imaging system using a 2.5 MHz probe. Tricuspid ring motion was measured by two-dimensional echo guided M-mode echocardiogram of the right lateral tricuspid ring. The excursion of the tricuspid ring during early diastole (dS; mm) and the peak rate of change of the excursion (dS/dt; mm/sec) were measured. We also assessed the right ventricular function by cine magnetic resonance imaging (MRI). Cine gradient echo images were obtained along the short axis of the right ventricle. The right ventricular volume at each phase of the cardiac cycle was calculated by Simpson's method and time–volume curves were constructed. The peak filling rate (dV/dt; ml/s) was determined from these time–volume curves. The dS was 12.8±2.5 mm, dS/dt was 132±27 mm/sec and dV/dt was 269±66 ml/s. There were significant positive correlations between dS and dV/dt (r=0.80, P〈0.01), and between dS/dt and dV/dt (r=0.45, P〈0.05). Based on our results, M-mode echocardiographic measurements of tricuspid ring motion may be used to assess the right ventricular diastolic function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006127128984
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrasonic tissue characterization in patients with dilated cardiomyopathy: comparison with findings from right ventricular endomyocardial biopsy (1999)
    Springer
    The international journal of cardiovascular imaging 15 (1999), S. 391-396 
    Details
    ISSN: 1573-0743
    Keywords: dilated cardiomyopathy ; integrated backscatter imaging ; right ventricular endomyocardial biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aim: The clinical usefulness of integrated backscatter (IB) imaging was compared with right ventricular endomyocardial biopsy for assessing myocardial damage in patients with dilated cardiomyopathy (DCM). Methods: We examined 15 patients with DCM and 20 healthy controls. In addition to the conventional M-mode echocardiographic parameters, we determined the cyclic variation in IB values (CV-IB) obtained from parasternal short axis views of the left ventricle just under the transducer for both the interventricular septum (IVS) and the left ventricular posterior wall (PW). The per cent fibrosis area (%) and the transverse diameter of myocytes (μm) were measured in right ventricular endomyocardial biopsy specimens by computer image analysis. To analyze the relationship between pathological findings and CV-IB, we divided patients into four subgroups on the basis of the pathological characteristics of endomyocardial biopsy specimens as follows: degeneration dominant group (n = 5), fibrosis dominant group (n = 5), dilated phase hypertrophic cardiomyopathy (n = 2), and mixed type (n = 3). Results: CV-IB in the IVS and the PW was lower in patients with DCM (8.8 ± 2.9, 8.3 ± 2.7 dB, respectively) than in normal subjects (14.4 ± 2.9, 13.6 ± 2.6 dB, respectively). Biopsy findings showed a mean per cent fibrosis area of 24.0 ± 12.3%, and a mean myocyte diameter of 14.3 ± 2.9 μm in patients with DCM. CV-IB was correlated with both of these findings: per cent fibrosis area (r = −0.56 in IVS, r = −0.56 in PW) and myocyte diameter (r = 0.67 in IVS, r = 0.71 in PW). CV-IB was decreased in all DCM subgroups compared with normal subjects, but there was no significant difference between subgroups. Conclusions: CV-IB was correlated with both the extent of fibrosis in myocardial tissue and the myocyte diameter. These findings suggest that ultrasonic tissue characterization is a good indicator of the severity of fibrosis and myocyte atrophy in patients with DCM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006272919061
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Activation of Transcription Factors and IL-8 Expression in Neutrophils Stimulated with Lipopolysaccharide from Porphyromonas gingivalis (1998)
    Springer
    Inflammation 22 (1998), S. 253-267 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract DNA binding activity of NF-κB and AP-1 were examined in neutrophils stimulated with LPS purified from P. gingivalis, a major pathogenic bacteria of periodontitis lesion. Porphyromonas gingivalis LPS enhanced the activity reaching a peak at a concentration of 500 ng/ml in the absence of serum. The NF-κB activation stimulated with 10 ng/ml of P. gingivalis LPS was suppressed approximately 44% by treatment of neutrophils with anti-CD14 antibody under the presence of serum. Increase in the steady-state IL-8 mRNA level was concomitantly observed by stimulation of neutrophils with 500 ng/ml of P. gingivalis LPS under the absence of serum. These results indicate that P. gingivalis LPS activates NF-κB and AP-1 in both serum-dependent and -independent manners, followed by increased IL-8 transcription in neutrophils, and suggested a role for P. gingivalis LPS in IL-8 synthesis by neutrophils in inflamed gingiva and GCF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022344031223
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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