ISSN:
1433-8580
Keywords:
Cholecystectomy
;
Colorectal tumors
;
Mice
;
1,2-Dimethylhydrazine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The influence of previous cholecystectomy (CCE) on the 1,2-dimethylhydrazine (DMH)-induced colorectal tumorigenesis was examined in 497 female NMRI mice after 14, 20, 24, 28, 33, and 36 weeks of induction time. There were only minor differences between the cholecystectomized and the non-cholecystectomized animals with regard to the percentage of tumor-bearing animals, number of adenomas, and location of the tumors. Only after an induction time of 20 weeks, the operated group had significantly more carcinoma-bearing animals than the non-operated group (P〈0.01,χ 2-test). The implication of these results on known data of epidemiologic studies in human colorectal cancer are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01852223
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