Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Observations on the dopaminergic nature of hyperthyroid chorea (1972)
    Springer
    Journal of neural transmission 33 (1972), S. 73-81 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hyperthyroid chorea is felt to be related to an increased response of striatal dopamine receptors to dopamine. This suggestion is supported by the observation that an agent which blocks dopamine receptors improved chorea in a hyperthyroid patient. An inverse relationship between thyroid status and brain dopamine turnover as estimated by CSF HVA levels was demonstrated. This observation suggests that hyperthyroidism increases the sensitivity of dopamine receptors to dopamine. This is the first example of increased receptor site sensitivity in the brain unassociated with a known structural lesion. An analogous mechanism is felt to be related to Huntington's chorea, but in this disease the increased receptor site response is due to structural alterations of the diseased neuron.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244729
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Dream phenomena induced by chronic levodopa therapy (1978)
    Springer
    Journal of neural transmission 43 (1978), S. 143-151 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-seven of eighty-eight (30.7%) Parkinsonian patients on chronic levodopa or levodopa/carbidopa therapy developed drug related dream phenomena. The patients reported three separate types of new dreams which we have classified as vivid dreams, night terrors and nightmares. These dreams are correlated to the duration of levodopa therapy although the mechanism of their production is unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01579073
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The effect of bromocriptine (BCT) on the on-off phenomenon (1981)
    Springer
    Journal of neural transmission 52 (1981), S. 41-47 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-three patients with idiopathic Parkinson disease with classic “on-off” phenomena were studied prospectively during treatment with bromocriptine (BCT). Patients were evaluated for an average of 6 to 12 months and received an average of 56.5 mg of BCT. Nine patients (39%) showed improvement in terms of “on-off”. When evaluated retrospectively, it appeared that the only difference between the responders and nonresponders was a younger mean age (57.1 to 63.2).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01253095
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The comparative roles of dopaminergic and serotonergic mechanisms in mediating quipazine induced locomotor activity (1982)
    Springer
    Journal of neural transmission 54 (1982), S. 145-151 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Quipazine maleate (50–100μg) injected bilaterally into the nucleus accumbens septi (NAS) of unpretreated rats produced a marked dose-dependent rise in locomotor activity (LA) that was nearly devoid of the stereotypies seen after the systemic or intrastriatal administration of this piperazine derivative. Injection of a low dose of the dopamine blocking agent haloperidol resulted in a marked antagonism of the LA elicited by quipazine (50μg) in the NAS; but methysergide, a central serotonin antagonist, was without effect. These results indicate that quipazine induced LA is mediated, at least partially, by DA receptors situated in the NAS, and that serotonin receptors do not play a significant role in this behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01254924
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Clinical and experimental studies of phenytoin-induced hyperkinesias (1979)
    Springer
    Journal of neural transmission 45 (1979), S. 291-305 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Phenytoin administration occasionally leads to the induction of hyperkinetic movement disorders. The pathophysiologic basis of this phenomena is unknown, but thought to be a toxic effect of phenytoin. Study of two cases of this disorder and a review of the literature suggest that antecedant pathologic changes in the basal ganglia are prerequisites for the development of phenytoin-induced hyperkinesias. In an animal model of tardive dyskinesia, phenytoin was found to enhance neuroleptic-induced behavioral supersensitivity but have no effect in control animals. We conclude that phenytoin induced hyperkinesias reflect a specific effect of phenytoin on an abnormal neural substrate and suggest the presence of an otherwise silent pathological alteration of the corpus striatum. The diagnostic value of an episode of phenytoin-induced hyperkinesia is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01247146
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Haloperidol-induced plasma prolactin release: Sensitivity, reliability, and comparison to haloperidol antagonism of dopamine agonist-induced stereotyped behavior in the rat (1982)
    Springer
    Psychopharmacology 78 (1982), S. 383-384 
    Details
    ISSN: 1432-2072
    Keywords: Plasma prolactin ; Screening model ; Apomorphine ; Haloperidol ; Stereotypy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of a known antipsychotic agent (haloperidol) were assessed using both a behavioral model and a prolactin (PRL) model for screening potential antipsychotic drugs in the rat. The PRL model was found to be highly reliable and more sensitive than the behavioral model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433748
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The comparative roles of dopaminergic and serotonergic mechanisms in mediating quipazine induced increases in locomotor acitivity (1983)
    Springer
    Journal of neural transmission 57 (1983), S. 27-37 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of dopaminergic and serotonergic agonists and antagonists on quipazine induced locomotor activity was investigated in rats. Though quipazine is generally considered to be a relatively pure serotonergic agonist, its effects on locomotor activity were inhibited by small doses of a centrally acting DA receptor blocking agent (haloperidol), while three different serotonergic (5-HT) antagonists were without effect on this behavior. Moreover, quipazine induced locomotor activity was markedly inhibited by the 5-HT substrate 5-hydroxytryptophan. The data suggest that quipazine induced locomotor activity primarily involves dopaminergic mechanisms, with 5-HT playing either no role in stimulating this behavior, or a subsidiary one, requiring intact central dopaminergic receptors for its expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250045
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    On the role of dopamine in the pathophysiology of anorexia nervosa (1976)
    Springer
    Journal of neural transmission 38 (1976), S. 107-122 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Based on a review of the pathophysiology of the major symptoms of anorexia nervosa, it was suggested that increased activity of dopamine at central dopamine receptors plays a role in the pathophysiology of this disorder. Although dopamine receptor site hypersensitivity, or synthesis, of a false transmitter could account for this, a defect in negative feedback control mechanisms is more consistent with the known characteristics of anorexia nervosa. The possible role of pure dopamine antagonists in symptomatic treatment and of dopamine agonists in reversing this disorder was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01262969
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    An experimental model of tardive dyskinesia (1972)
    Springer
    Journal of neural transmission 33 (1972), S. 235-246 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary There are numerous clinical and experimental similarities between amine induced stereotyped behavior and tardive dyskinesia. The results presented here show that chronic pretreatment of guinea pigs with chlorpromazine produces a persistent reduction in the amounts of amphetamine or apomorphine needed to induce stereotyped behavior. It is suggested that chlorpromazine pretreatment may alter the sensitivity of the striatal dopaminergic receptors to dopamine. The alteration in receptor site responsiveness produced by prolonged chlorpromazine pretreatment may be analogous to the neuroleptic induced tardive dyskinesias. The same dopaminergic mechanism may underlie both the amine stereotyped behavior seen in animals and tardive dyskinesias in man, while lingual-facial-buccal dyskinesias may be the human equivalent of the stereotypies seen in animals when the dopaminergic response in the striatum is increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245320
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Dopamine receptor site sensitivity in hyperthyroid guinea pigs: A possible model of hyperthyroid chorea (1973)
    Springer
    Journal of neural transmission 34 (1973), S. 187-193 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Guinea pigs made hyperthyroid were found to have increased responsiveness to dopaminergic stimulation of the striatum as measured by the dosage of apomorphine necessary to elicit stereotyped behavior. A dosage of apomorphine which produced stereotyped behavior in only 3 out of 36 euthyroid guinea pigs induced this behavior in 18 out of 20 hyperthyroid guinea pigs. This observation suggests that striatal dopamine receptor site sensitivity is increased in hyperthyroidism and is consistent with the hypothesis that increased receptor site sensitivity plays a role in the pathophysiology of hyperthyroid chorea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01367508
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...