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  • 1
    Electronic Resource
    Electronic Resource
    Preclinical Wound-Healing Studies with Recombinant Human Basic Fibroblast Growth Factor (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 638 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb49042.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Functional significance of interrenal cell zonation in the adrenal gland of the duck (Anas platyrhynchos) (1979)
    Springer
    Cell & tissue research 201 (1979), S. 23-36 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal zonation ; Corticosterone ; Aldosterone ; Birds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Slices of whole adrenal gland tissue, incubated in vitro in the presence of ACTH for 1 h and 2 h produced corticosterone and aldosterone in constant ratio (16∶1). Tangential slices taken from the region immediately below the connective tissue capsule and slices taken from deeper regions of the gland consisted primarily of cells conforming to the distinct structural characteristics of the subcapsular zone (SCZ) and inner zone (IZ) tissues respectively. When samples were incubated in the presence of ACTH for 1 h and 2 h, the interrenal cells of the SCZ produced relatively more aldosterone than cells taken from the IZ of the gland. The corticosterone: aldosterone ratio for the IZ after 1 h (68∶1) and after 2 h (102∶1) were ten times greater than the ratios for the SCZ after 1 h (7∶1) and after 2 h (10∶1). The SCZ slices were not more than 60 cells thick and consisted of cells arranged in cords. These cells contained irregular nuclei, mitochondria with shelf-like cristae and a moderate abundance of smooth endoplasmic reticulum. In contrast, the production of large amounts of corticosterone by the cells of the IZ was associated with tissue containing more vascular space than the SCZ and the cells contained large round nuclei surrounded by an abundance of smooth endoplasmic reticulum and the mitochondria had tubular rather than shelf-like cristae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238044
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The Effect of Sodium Tauro-24,25-Dihydrofusidate on the Nasal Absorption of Human Growth Hormone in Three Animal Models (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 547-552 
    Details
    ISSN: 1573-904X
    Keywords: nasal delivery ; sodium taurodihydrofusidate (STDHF) ; human growth hormone ; bioavailability ; absorption enhancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The ability of a novel permeation enhancer, sodium tauro-24,25-dihydrofusidate (STDHF), to increase the systemic delivery of human growth hormone (hGH); after intranasal administration was investigated in rat, rabbit, and sheep. Formulations of hGH with STDHF exhibited greatly enhanced nasal absorption at concentrations of STDHF above its critical micelle concentration. The increase in bioavailability was 11-fold in rats and in rabbits and 21-fold in sheep for formulations containing 0.5% STDHF as compared to those without STDHF. Glycocholate or taurocholate at 0.5% was three to five times less effective than STDHF at enhancing hGH absorption in rats. Additionally, the pulsatile absorption kinetics observed after intranasal delivery more closely resemble the endogenous secretory pattern of hGH than those obtained following subcutaneous administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015885204249
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    Paper (German National Licenses)
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