ISSN:
1573-904X
Keywords:
dihydroxymethylxanthones
;
monoamine oxidase (MAO)
;
MAO-A
;
selective reversible inhibitors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract l,3-Dihydroxy-2-methylxanthone (XI), its 4-chloro and 4-bromo derivatives (X1-C1 and Xl-Br), and 1 ,3-dihydroxy-4-methylxanthone were investigated for their inhibition activities toward MAO. A hyperbolic function was derived to fit the data and to calculate IC50 values. The compounds proved to be reversible and selective inhibitors of MAO-A, with XI displaying the highest activity (IC50 = 3.7 µM).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018924503552
Permalink