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  • 1
    Electronic Resource
    Electronic Resource
    A germline insertion in the tuberous sclerosis ( Tsc2 ) gene gives rise to the Eker rat model of dominantly inherited cancer (1995)
    [s.l.] : Nature Publishing Group
    Nature genetics 9 (1995), S. 70-74 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The Eker rat hereditary renal carcinoma (RC) is an excellent example of a mendelian dominant predisposition to a specific cancer in an experimental animal. We have previously established a new conserved linkage group on rat chromosome 10q and human chromosome 16p13.3, and shown that the Eker ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0195-70
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  • 2
    Electronic Resource
    Electronic Resource
    Urinary metallothionein as a new index of renal dysfunction in “itai-itai” disease patients and other Japanese women environmentally exposed to cadmium (1982)
    Springer
    Archives of toxicology 50 (1982), S. 159-166 
    Details
    ISSN: 1432-0738
    Keywords: Cadmium ; Metallothionein ; Renal dysfunction ; “Itai-itai” disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The significance of elevated excretion of metallothionein in urine of women living in cadmium-polluted and non-polluted areas of Japan was studied with respect to renal dysfunction. The relationships between the concentrations of metallothionein in urine and those of other non-specific urinary indices of renal dysfunction, i.e., total protein, glucose, β2-microglobulin, retinol-binding protein, α-amino nitrogen and proline were examined. In addition, the relationships between urinary metallothionein and urinary cadmium and copper were also evaluated. It was found that the logarithm of the metallothionein concentration in urine was significantly correlated with the logarithm of the concentrations of each of the above parameters. When subjects with signs of renal dysfunction, including “itai-itai” disease patients and patients suspected of the disease, were compared with subjects with normal renal functions, as a group, the former excreted significantly higher concentrations of metallothionein in their urine than the latter. The results suggest that the elevated excretion of metallothionein is not only an index of excessive cadmium exposure, but also of renal dysfunction caused by chronic exposure to this metal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373398
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Pulmonary clearance and toxicity of zinc oxide instilled into the rat lung (1989)
    Springer
    Archives of toxicology 63 (1989), S. 336-342 
    Details
    ISSN: 1432-0738
    Keywords: Zinc oxide ; Lung ; Pulmonary clearance ; Metallothionein ; Bronchoalveolar lavage fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pulmonary toxicity of zinc oxide (ZnO) was evaluated by investigating the metabolic fate and inflammatory potency of ZnO instilled into the rat lung. Groups of three rats received single intratracheal instillations of ZnO suspension at a dose of 100 μg Zn/rat in the timecourse experiment or received 20, 50, 100, 200, 500 and 1000 μg Zn/rat and were killed 2 days after treatment in the dose-response experiment. It was suggested that ZnO particles were solubilized in the bronchoalveolar milieu and cleared from the lung with a half-life of 14 h. Metallothionein (MT) was induced with a peak at 2 days. The content of MT was proportional to the dose of ZnO, but contributed little for the accumulation of Zn in the lung. A dose of 20 μg Zn/rat was sufficient to develop maximum responses for β-glucuronidase activity and surfactant content in the bronchoalveolar lavage fluid. Moreover, the activity of lactate dehydrogenase and protein content in the lavage fluid increased significantly at 20 μg Zn/rat. These results suggest that the recommended ZnO concentration in the work-place atmosphere of 5 mg/m3 might not be adequate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278649
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  • 4
    Electronic Resource
    Electronic Resource
    Parathyroid hormone concentration in the serum of people with cadmium-induced renal damage (1984)
    Springer
    International archives of occupational and environmental health 54 (1984), S. 187-193 
    Details
    ISSN: 1432-1246
    Keywords: Parathyroid hormone ; Cadmium ; Bone change ; Renal damage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum parathyroid hormone (PTH) and renal functions were measured in thirty subjects with cadmium-induced renal damage and in the same number of control subjects. The negative correlations between PTH and creatinine clearance (Ccr) and between PTH and percentage renal phosphorus reabsorption (% TRP) were significant in the cadmium (Cd)-exposed group. Serum PTH concentrations were clearly high in two cases of the cadmium-exposed group. Their renal functions decreased severely compared with those of the other Cd-exposed people. The present study indicates that chronic cadmium intoxication could cause increased secretions of PTH, which may be related to cadmium-induced bone damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00379048
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  • 5
    Electronic Resource
    Electronic Resource
    Optical resolution by preferential crystallization of (2RS,3SR)-2-amino-3-chlorobutanoic acid hydrochloride (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 9 (1997), S. 656-660 
    Details
    ISSN: 0899-0042
    Keywords: β-chloro-α-amino acid ; conglomerate ; successive optical resolution ; racemic structure ; (2RS,3SR)-ACB · HCl ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: (2RS,3SR)-2-Amino-3-chlorobutanoic acid hydrochloride [(2RS,3SR)-ACB · HCl] was found to exist as a conglomerate based on the melting point, infrared spectrum, and solubility. Optical resolution by preferential crystallization of (2RS,3SR)-ACB · HCl was achieved to yield both (2R,3S)- and (2S,3R)-ACB · HCl of 80-100% optical purities. The obtained (2R,3S)- and (2S,3R)-ACB · HCl were recrystallized, taking into account the solubility of (2RS,3SR)-ACB · HCl, to give efficiently optically pure (2R,3S)- and (2S,3R)-ACB · HCl. Treatment of the purified (2R,3S)- and (2S,3R)-ACB · HCl with triethylamine gave optically pure (2R,3S)- and (2S,3R)-2-amino-3-chlorobutanoic acid, respectively. Chirality 9:656-660, 1997. © 1997 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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