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  • 1
    Electronic Resource
    Electronic Resource
    Magneto-optical memory media using BaTiON protective films (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 68 (1990), S. 4325-4326 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new protective and enhancing film for magneto-optical memory media—BaTiON has been developed. The values of refractive index and extinction coefficient of the film were 2.75 and 0, respectively. Calculations give maximum Kerr rotation angles of 1.4 deg for three-layer-type media and more than 10 deg for reflective-layer-type media when such a film is used to enhance the rotation. The magneto-optical memory media using the film showed excellent recording characteristics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.346203
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  • 2
    Electronic Resource
    Electronic Resource
    High-speed surface temperature measurements on plasma facing materials for fusion applications (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 178-184 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: For the lifetime evaluation of plasma facing materials in fusion experimental machines, it is essential to investigate their surface behavior and their temperature responses during an off-normal event such as the plasma disruptions. An infrared thermometer with a sampling speed as fast as 1×10−6 s/data, namely, the high-speed infrared thermometer (HSIR), has been developed by the National Research Laboratory of Metrology in Japan. To evaluate an applicability of the newly developed HSIR on the surface temperature measurement of plasma facing materials, high heat flux beam irradiation experiments have been performed with three different materials under the surface heat fluxes up to 170 MW/m2 for 0.04 s in a hydrogen ion beam test facility at the Japan Atomic Energy Research Institute. As for the results, HSIR can be applicable for measuring the surface temperature responses of the armor tile materials with a little modification. It is also confirmed that surface temperatures measured with the HSIR thermometer show good agreement with the analytical results for stainless steel and carbon based materials at a temperature range of up to 2500 °C. However, for aluminum the HSIR could measure the temperature of the high dense vapor cloud which was produced during the heating due to lower melting temperature. Based on the result, a multichannel arrayed HSIR thermometer has been designed and fabricated. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146567
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  • 3
    Electronic Resource
    Electronic Resource
    Possibility of dc drift reduction of Ti:LiNbO3 modulators via dry O2 annealing process (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 1180-1182 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The possibility of the dc drift reduction of Ti:LiNbO3 optical modulators via the dry O2 annealing process of the wafer is investigated. In such modulators, the hydrogen impurities are reduced compared against those in the wet O2 annealed ones which exhibit large dc drifts. The dc drifts are observed to be less than 3 V for the dc bias application of 5 V at 80 °C through 60 h, but the dc drift in the second measurement of the same modulator is found to 5 V. After the bias application, the migration of H+ ions are observed in the Ti:LiNbO3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.110882
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  • 4
    Electronic Resource
    Electronic Resource
    Restoration of macrophage tumoricidal activity by bleomycin correlates with the decreased production of transforming growth factor β in rats bearing KDH-8 hepatoma cells (1997)
    Springer
    Cancer immunology immunotherapy 45 (1997), S. 71-76 
    Details
    ISSN: 1432-0851
    Keywords: Key words Macrophage ; Nitric oxide ; Interferon γ ; Transforming growth factor β ; Bleomycin ; Tumor-bearing rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  To explore the mechanisms of immuno-modulatory activities of bleomycin, we investigated interferon γ (IFNγ) mRNA expression, tumor necrosis factor α (TNFα) production, nitric oxide (NO) production and macrophage tumoricidal activities in rats bearing KDH-8 hepatoma cells, which secreted a large amount of transforming growth factor β (TGFβ), and these processes in KDH-8 tumor-bearing rats treated with bleomycin. We found that IFNγ mRNA expression, TNFα production, NO production and macrophage cytotoxic activities were lower in the KDH-8-bearing rats than in normal rats. On the other hand, low-dose bleomycin restored the macrophage cytotoxic activities, NO production, IFNγ mRNA expression and TNFα production in the KDH-8-bearing rats. In vitro experiments showed that KDH-8-derived TGFβ decreased the IFNγ mRNA expression and TNFα production in splenocytes, and NO production in peritoneal macrophages. These results suggest that low-dose bleomycin restored the cytokine production and macrophage tumoricidal activities in the KDH-8-bearing rats by decreasing KDH-8-derived TGFβ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050404
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  • 5
    Electronic Resource
    Electronic Resource
    Restoration of interleukin-2 production in tumor-bearing rats through reducing tumor-derived transforming growth factor β by treatment with bleomycin (1995)
    Springer
    Cancer immunology immunotherapy 41 (1995), S. 355-362 
    Details
    ISSN: 1432-0851
    Keywords: Immunosuppression ; Transforming growth factor ß ; Interleukin-2 ; Bleomycin ; Tumor-bearing rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied mechanisms of immunosuppression caused by tumor-derived transforming growth factor-ß (TGFß) and restoration of the immune response by treatment with bleomycin in rats bearing KDH-8 hepatoma. Interleukin-2 (IL-2) production from splenocytes of KDH-8-tumor-bearing rats progressively decreased as the KDH-8 tumor grew. IL-2 production from concanavalin-A-stimulated normal rat splenocytes was signficiantly inhibited by in vitro cultured KDH-8-tumor-cell-conditioned medium; this inhibition could be blocked by neutralizing the conditioned medium with anti-TGFß antibody. TGFß activities were found in KDH-8-tumor-tissue-conditioned medium without acid treatment and were found in tumor-cell-conditioned medium after acid treatment; TGFß mRNA and TGFß protein were found in cultured KDH-8 tumor cells. These results suggested that the KDH-8-tumor-derived TGFß might be involved in the inhibition of IL-2 production from splenocytes. To determine whether bleomycin chemotherapy could reduce tumor-derived TGFß and restore the immune responses, we treated KDH-8 tumor-bearing rats with bleomycin (5 mg/kg, one shot) at an appropriate time (before the occurrence of immunosuppression) resulting in a significiant reduction of TGFß activity in KDH-8 tumor tissues and restoration of IL-2 production from splenocytes of tumor-bearing rats; KDH-8 tumor growth ultimately regressed. In vitro experiments also showed that TGFß activity, mRNA expression, and protein synthesis in KDH-8 tumor cells were reduced by bleomycin treatment, and that bleomycin-treated-KDH-8-tumor-cell-conditioned medium did not inhibit IL-2 production from normal rat splenocytes. These results suggest that bleomycin treatment restored IL-2 production in tumor-bearing rats through reducing the tumor-derived TGFß.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01526555
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  • 6
    Electronic Resource
    Electronic Resource
    Restoration of interleukin-2 production in tumor-bearing rats through reducing tumor-derived transforming growth factor &;b by treatment with bleomycin (1996)
    Springer
    Cancer immunology immunotherapy 41 (1996), S. 355-362 
    Details
    ISSN: 1432-0851
    Keywords: Key words Immunosuppression ; Transforming growth factor β ; Interleukin-2 ; Bleomycin ; Tumor-bearing rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We studied mechanisms of immunosuppression caused by tumor-derived transforming growth factor-β (TGFβ) and restoration of the immune response by treatment with bleomycin in rats bearing KDH-8 hepatoma. Interleukin-2 (IL-2) production from splenocytes of KDH-8-tumor-bearing rats progressively decreased as the KDH-8 tumor grew. IL-2 production from concanavalin-A-stimulated normal rat splenocytes was signficiantly inhibited by in vitro cultured KDH-8-tumor-cell-conditioned medium; this inhibition could be blocked by neutralizing the conditioned medium with anti-TGFβ antibody. TGFβ activities were found in KDH-8-tumor-tissue-conditioned medium without acid treatment and were found in tumor-cell-conditioned medium after acid treatment; TGFβ mRNA and TGFβ protein were found in cultured KDH-8 tumor cells. These results suggested that the KDH-8-tumor-derived TGFβ might be involved in the inhibition of IL-2 production from splenocytes. To determine whether bleomycin chemotherapy could reduce tumor-derived TGFβ and restore the immune responses, we treated KDH-8 tumor-bearing rats with bleomycin (5 mg/kg, one shot) at an appropriate time (before the occurrence of immunosuppression) resulting in a significiant reduction of TGFβ activity in KDH-8 tumor tissues and restoration of IL-2 production from splenocytes of tumor-bearing rats; KDH-8 tumor growth ultimately regressed. In vitro experiments also showed that TGFβ activity, mRNA expression, and protein synthesis in KDH-8 tumor cells were reduced by bleomycin treatment, and that bleomycin-treated-KDH-8-tumor-cell-conditioned medium did not inhibit IL-2 production from normal rat splenocytes. These results suggest that bleomycin treatment restored IL-2 production in tumor-bearing rats through reducing the tumor-derived TGFβ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01526555
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  • 7
    Electronic Resource
    Electronic Resource
    Polysaccharide K induces Mn superoxide dismutase (Mn-SOD) in tumor tissues and inhibits malignant progression of QR-32 tumor cells: possible roles of interferon α, tumor necrosis factor α and transforming growth factor β in Mn-SOD induction by polysaccharide K (1998)
    Springer
    Cancer immunology immunotherapy 46 (1998), S. 338-344 
    Details
    ISSN: 1432-0851
    Keywords: Key words Tumor progression ; PSK ; TGFβ ; IFNγ ; Mn-SOD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Previously we reported the malignant progression of QR-32, a regressor-type tumor clone, following co-implantation with foreign bodies (gelatin sponge or plastic plate) in normal syngeneic C57BL/6 mice. We also reported that the progression of QR-32 cells by a gelatin sponge was significantly inhibited in the mice administered polysaccharide K (PSK) and that PSK induced an increase of radical scavengers, especially manganese superoxide dismutase (Mn-SOD), locally at the site of tumor tissues. In this study, to reveal the possible mechanism by which PSK induced Mn-SOD in the tumor tissues, we examined the mRNA expression and protein levels of inflammatory cytokines in the tissues. We found that mRNAs of tumor necrosis factor α (TNFα) and interleukin-1α (IL-1α) were considerably expressed in both PSK-treated and phosphate-buffered-saline-treated tumors, and that the mRNA expression and protein level of interferon γ (IFNγ) increased in the tumor tissues treated with PSK. In vitro treatment of QR-32 cells with IFNγ did not significantly increase the production of Mn-SOD; however, the combination of IFNγ with TNFα increased the Mn-SOD production more effectively than did any of the cytokines used singly. Furthermore, we observed the down-regulation of the mRNA expression and protein level of transforming growth factor β (TGFβ) in the tumor tissues treated with PSK, and that in vitro treatment of QR-32 cells with TGFβ decreased the production of Mn-SOD. These results suggest that PSK suppresses the progression of QR-32 cells by increasing Mn-SOD via the modulation of inflammatory cytokines; that is, by decreasing TGF-β and increasing IFN-γ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050495
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  • 8
    Electronic Resource
    Electronic Resource
    Activated leukocyte cell adhesion molecule (ALCAM) and annexin II are involved in the metastatic progression of tumor cells after chemotherapy with Adriamycin (2000)
    Springer
    Clinical & experimental metastasis 18 (2000), S. 45-50 
    Details
    ISSN: 1573-7276
    Keywords: ALCAM ; annexin II ; chemotherapy ; metastasis ; progression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Metastasis frequently occurs during and/or after chemotherapy resulting in failure. This suggests that inadequate chemotherapy promotes the emergence of more malignant tumor cells with metastatic potential. However, it is not determined how chemotherapy could promote the metastatic progression of tumor cells. In this study, we isolated highly metastatic clones from the tumors treated with ADR using an in vivo experimental model, in which non-metastatic tumor cells were inoculated s.c. in mice, treated with or without Adriamycin and then culture lines were re-established from the tumors. Then we isolated cDNAs for activated leukocyte cell adhesion molecule (ALCAM), osteopontin, and annexin II as candidates for metastasis-promoting genes with the use of a PCR-based subtraction method. Further we examined the metastatic potential of transfectants over-expressing ALCAM, osteopontin, or annexin II and combinations of them. Metastasis to the lung was observed in the mice where transfectants over-expressing ALCAM plus annexin II had been inoculated via tail vein. These results suggest that the over-expression of ALCAM and annexin II play a role in the metastatic progression after chemotherapy with ADR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026507713080
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