ISSN:
1573-8221
Keywords:
angiotensin II
;
hemodynamics
;
peptide metabolism in the liver
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Changes in the general hemodynamics were studied in healthy unanesthetized dogs after injection of angiotensin II for 60 min into the superior vena cava and portal vein at the rate of 27 ng/kg/min. Portal administration of the peptide was found to induce a weaker pressor effect. After systemic injection of angiotensin II the arterial pressure rose as the result of an increase in peripheral vascular resistance, and the minute volume of the circulation was reduced. After portal injection of angiotensin the increase in arterial pressure was due chiefly to an increase in the minute volume of the circulation. The differences in the hemodynamic responses cannot be explained entirely by metabolism of the peptide in the liver. After portal injection of angiotensin II it is possible that depressor substances from the liver enter the blood stream.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00797117
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