ISSN:
1573-8221
Keywords:
inner mitochondrial membranes
;
protein synthesis
;
protein spectrum
;
isoproterenol sulfate
;
disseminated necrosis of the myocardium
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Two fractions of the inner mitochondrial membranes were isolated from the rat myocardium: a combination of inner membranes and matrix (fraction A) and aggregates of inner membranes without matrix (fraction B). Both membrane fractions were shown to incorporate labeled amino acids with equal activity. Experiments with anodic electrophoresis in polyacrylamide gel showed that the number of protein components in fractions A and B varies from 20–30 and their molecular weights from 10,000 to 200,000. Disseminated necroses in the myocardium produced by Novodrin (isoproterenol sulfate), based on an ischemic state of the heart, led after 2 days to a marked decrease in the protein-synthesizing activity of fractions A and B. The protein profiles and molecular weights of the components of the membrane proteins were not appreciably altered.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00842651
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