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  • 1
    Electronic Resource
    Electronic Resource
    Melatonin levels decrease in type 2 diabetic patients with cardiac autonomic neuropathy (2005)
    Oxford, UK : Munksgaard International Publishers
    Journal of pineal research 39 (2005), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  The present study has been designed to determine melatonin levels in type 2 diabetic patients and test the relationship between the autonomic nervous system and melatonin dynamics. Thirty-six type 2 diabetic patients and 13 age-matched healthy subjects were recruited for the study. Circadian rhythm of melatonin secretion was assessed by measuring serum melatonin concentrations between 02:00–04:00 and 16:00–18:00 hr. Melatonin dynamics were re-evaluated with respect to autonomic nervous system in diabetic patients with autonomic neuropathy who were diagnosed by the cardiovascular reflex tests, heart rate variability (HRV), and 24-hr blood pressure monitoring. Nocturnal melatonin levels and the nocturnal melatonin surge were low in the diabetic group (P = 0.027 and 0.008 respectively). Patients with autonomic neuropathy revealed decreased melatonin levels both at night and during day when compared with healthy controls (P 〈 0.001 and 0.004 respectively) while the melatonin dynamics were similar to controls in patients without autonomic neuropathy. Nocturnal melatonin level was positively correlated with nocturnal high and low frequency components of HRV (P = 0.005 and 0.011 respectively) and systolic and diastolic blood pressures at night (P = 0.002 and 0.004 respectively) in patients with autonomic neuropathy. We found a negative correlation between nocturnal melatonin levels and the degree of systolic blood pressure decrease at night (r = −0.478, P = 0.045). As a conclusion this study has shown that circadian rhythm of melatonin secretion is blunted in type 2 diabetic patients and there is a complex relationship between various components of autonomic nervous system and melatonin secretion at night. Among the patients with autonomic neuropathy those with more preserved HRV and the systolic nondippers (〈10% reduction in blood pressure during the night relative to daytime values) have more pronounced melatonin surge at night.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.2005.00213.x
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma atrial natriuretic peptide and endothelin levels in acute poststreptococcal glomerulonephritis (1992)
    Springer
    Pediatric nephrology 6 (1992), S. 519-522 
    Details
    ISSN: 1432-198X
    Keywords: Acute poststreptococcal glomerulonephritis ; Atrial natriuretic peptide ; Endothelin ; Sodium retention ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma levels of atrial natriuretic peptide (ANP) and of endothelin (ET) were significantly elevated (87.7±13.9 pg/ml and 79.7±10.8pg/ml, respectively) during the acute phase of acute poststreptococcal glomerulonephritis (APSGN). Plasma renin levels were normal, fractional excretion of sodium (FENa) was 0.5±0.1% and creatinine clearance (C Cr) averaged 82.2±18.3 ml/min per 1.73 m2. In the recovery phase of the disease (n=12), levels of ANP (23.6±6.7 pg/ml) and ET (43.1±2.4 pg/ml) fell and were not significantly different from those measured in 11 control subjects. FENa increased to 1.3±0.1% andC Cr to 113.5±12.1 ml/min per 1.73 m2 (all values mean ± standard error). ANP did not correlate with PRA, blood pressure,C Cr or FENa. There was an inverse relationship between the ET level and FENa in the acute phase of the disease (r=0.489,P〈0.05), but no significant correlation between ET and blood pressure, PRA,C Cr or ANP was found. We suggest that, despite the sodium retention, the increased ANP level in APSGN indicates unresponsiveness of the kidneys to ANP; the increased ET levels may contribute to this.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866489
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