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  • 1
    Digitale Medien
    Digitale Medien
    Lipidosis of the dorsal root ganglia in rats treated with an almitrine metabolite (1995)
    Springer
    Archives of toxicology 69 (1995), S. 391-396 
    Details
    ISSN: 1432-0738
    Schlagwort(e): Key words Almitrine bismesylate ; Detriazinyl ; metabolite of almitrine ; Cationic amphiphilic drugs ; Drug-induced lipidosis ; Neuropathy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appeared, and lamellated and/or crystalloid bodies formed in sensory neurons, satellite cells, Schwann cells, and vascular endothelial cells of the dorsal root ganglia. The lysosomal lamellated bodies, which were not induced by almitrine, were produced also in cultured rat macrophages exposed to over 1×10–5 M DTMA.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002040050189
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Bone metabolic disorders caused by small bowel resection, and the influence of 1α-hydroxyvitamin D3 on the rats (1990)
    Springer
    Journal of bone and mineral metabolism 8 (1990), S. 17-25 
    Details
    ISSN: 1435-5604
    Schlagwort(e): Small Bowel Resection ; Bone Metabolic Disorder ; 1α-hydroxyvitamin D3
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Metabolic bone disorders caused by resection of the distal three quarters of the small bowel and the effects of 1α-hydroxyvitamin D3 (1α(OH)D3) on the rats were investigated biochemically and histomorphologically. 1α(OH)D3 was administered orally to the rats for 13 weeks. A group of “ sham operation” animals and the 75%-distal-small-bowel-resected control animals received only the vehicle. Bone changes developed 13 weeks after the partial bowel resection. The disorder was characterized by reductions in ash content of the femur and by the disappearance of the trabecular bone in tibial metaphysis. Decreased Ca absorption from the intestines was demonstrated by a radiotracer technique, and biochemical studies showed significant decreases in serum Ca and 1,25(OH)2D concentrations in the bowel-resected rats. These findings suggest that 75% distal small bowel resection impairs intestinal absorption of calcium and results in a negative calcium balance, which may contribute to the development of bone metabolic disorder in rats. This disorder was demonstrated as high bone turnover via urinalysis and by a radiotracer technique. Administration of 1α(OH)D3 increased dose-dependent Ca absorption from the intestine and the serum Ca, normalized the bone turnover rate and prevented the development of bone metabolic disorder.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02374740
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Effect of 1α-hydroxyvitamin D3 on bone metabolic disorders in gastrectomized rats (1990)
    Springer
    Journal of bone and mineral metabolism 8 (1990), S. 10-16 
    Details
    ISSN: 1435-5604
    Schlagwort(e): Gastrectomy ; Bone Metabolic Disorder ; 1α-hydroxy vitamin D3
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effect of 1α-hydroxyvitamin D3 (1α(OH)D3) on the metabolic bone disorders developed in gastrectomized rats were investigated biochemically and histomorphologically. 1α(OH)D3 was suspended in 0.2 % Triton-X-100 aqueous solution after dissolving in a very small amount of ethanol, was given orally to the rats for 10 weeks. The sham operated animals and the gastrectomy control animals received the vehicle alone. Gastrectomy was followed by the development of the metabolic bone disorders after 10 weeks of observation. This was characterized by reduction in ash content of the femur and histologically by a disappearance of the trabecular bone in tibial metaphysis. Decrease Ca absorption from the intestines was demonstrated by a radiotracer technique. Biochemical studies showed significant decreases in serum 25(OH)D concentration in gastrectomized rats. These findings suggest that gastrectomy partially impairs intestinal absorption of calcium and results in a negative calcium balance, which may contribute to the development of bone metabolic disorders in rats. The administration of 1α(OH)D3 increased dose-dependently serum calcium and Ca absorption from the intestine and prevented the development of bone metabolic disorders histomorphologically.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02374739
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