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  • 1
    Electronic Resource
    Electronic Resource
    THE ROLE OF H-2 REGION INCOMPATIBILITIES IN GRAFT-VERSUS-HOST REACTIONS RAISED BY THYMUS CELLS (1975)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 2 (1975), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Graft-versus-host reaction, after injection of parental thymus cells into F1 hybrid recipients, was measured by popliteal lymph node assay in combinations of congenic strains which involve incompatibilities at various regions of the H-2 gene complex. The results indicate that incompatibility at genes in the I-A, I-B regions or their vicinity results in the strongest graft-versus-host reaction. Incompatibility at genes associated with the I-E region also was effective, while no graft-versus-host reaction was seen in combinations with I-C, S, and D region incompatibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1975.tb00537.x
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  • 2
    Electronic Resource
    Electronic Resource
    H - Y ANTIGEN: GENETIC CONTROL OF THE EXPRESSION AS DETECTED BY HOST - VERSUS - GRAFT POPLITEAL LYMPH NODE ENLARGEMENT ASSAY MAPS BETWEEN THE T AND H - 2 COMPLEXES (1979)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 6 (1979), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: We are using the terms ‘low’ and ‘high’ expression when the H-Y antigen on thymocytes of mouse parental strains is, respectively, weakly and strongly immunogenic for F1 hybrids in a host-versus-graft popliteal lymph node enlargement assay. Using this assay we attempted to locate the genetic factor(s) responsible for the control of H-Y expression within chromosome 17 since our previous study indicated linkage with the H-2 complex. We produced to this aim recombinants from (B10.T x C3H/Di)F1 hybrids where crossing over took place between H-2 and T complexes. In this way we were able to locate a gene denoted Hye (for H-Y expression) whose ‘high’ and ‘low’ alleles originated, respectively, from the B10 and C3H/Di strains. In the recombinants, the expression did not follow the H-2 haplotype, but obviously depended on the position of crossing over between H-2 and T. This pointed to the Hye gene mapping proximally from the H-2 complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1979.tb00697.x
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular cloning and expression of the human and mouse homologues of the Drosophila dachshund gene (1999)
    Springer
    Development genes and evolution 209 (1999), S. 537-545 
    Details
    ISSN: 1432-041X
    Keywords: Key words Dachshund ; Pax6 ; Eye ; Limb ; Mammalian development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Recent genetic analysis of the Drosophila dachshund (dac) gene has established that dac encodes a novel nuclear protein that is involved in both eye and leg development. In the Drosophila eye, dac expression appears to be controlled by the product of the eyeless/Pax6 gene. In order to analyze the Pax6 pathway in vertebrates we have isolated and characterized the cDNA and genomic clones corresponding to the human and mouse homologues of Drosophila dac. A full-length human cDNA encoding dachshund (DACH) encodes the 706 amino acids protein with predicted molecular weight of 73 kDa. A 109 amino acid domain located at the N-terminus of the DACH showed significant sequence and secondary structure homologies to the ski/sno oncogene products. Northern blot analysis found human DACH predominantly in adult kidney, heart, and placenta, with less expression detected in the brain, lung, skeletal muscle and pancreas. A panel of human cell lines was studied and most notably a large proportion of neuroblastomas expressed DACH mRNA. Mouse Dach encodes a protein of 751 amino acids with predicted molecular weight of 78 kDa that is 95% identical to the human DACH. RNase protection analysis showed the highest Dach mRNA expression in the adult mouse kidney and lung, whereas lower expression was detected in the brain and testis. RT/PCR analysis readily detected Dach mRNA in the adult mouse cornea and retina. Dach mRNA expression in the mouse E11.5 embryo was observed primarily in the fore and hind limbs, as well as in the somites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004270050286
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  • 4
    Electronic Resource
    Electronic Resource
    A cloned H-2 class I gene from a t w32-derived recombinant t haplotype identified as functional tH-2KtH-2KtH-2K q gene (1988)
    Springer
    Immunogenetics 28 (1988), S. 283-285 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345507
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  • 5
    Electronic Resource
    Electronic Resource
    Expression of the H-Y Antigen on thymus cells and skin: Differential genetic control linked toK end ofH-2 (1976)
    Springer
    Immunogenetics 3 (1976), S. 583-594 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The strength of the H-Y antigen on thymus cells and on skin was compared in differentH-2-congenic mouse strains using a host-versus-graft reaction popliteal lymph node assay, and skin grafts from males of parental strains grafted to F1 hybrid females. The results revealed considerable differences in the strength of the H-Y antigen among different congenic strains; these differences demonstrate the effect of theH-2-linked gene on the expression of the H-Y antigen. The linkage withH-2 was also confirmed in tests with segregating F2 generations. In the strains bearing recombinantH-2 haplotypes, the strength of the H-Y antigen is similar to that of parental strain from which the recombinant received itsK end, and the responsible gene (or genes) map to the left ofI-C. The effect of theH-2-linked gene(s) on thymus cells and skin is different. The gene linked to theK end ofH- 2b determines a strong H-Y antigen on thymus cells, but a relatively weak H-Y antigen on skin. The gene linked to theK end ofH- 2k determines a weak H-Y antigen on thymus cells, but a strong H-Y antigen on skin. The gene linked to theK end ofH- 2d determines a weak H-Y antigen on both thymus cells and skin. Our observations raise the possibility that the structural gene for the H-Y antigen is linked toH-2. Alternative (but not exclusive) explanations invoke regulatory effects ofH-2 on the expression of the H-Y antigen, possibly by means of the control of the cellular andogen receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01576988
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