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  • 1
    Electronic Resource
    Electronic Resource
    Chronic and Continuous ICV Infusion of Neuropeptide Y Disrupts the Nycthemeral Feeding Patterns in Rats (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 611 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb48996.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 76 (1991), S. 79-88 
    Details
    ISSN: 0303-7207
    Keywords: Androgen receptor ; Cell culture ; LNCaP ; Regulation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0303-7207(91)90262-Q
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Prostate-specific antigen as a marker of prostate disease (2000)
    Springer
    Virchows Archiv 436 (2000), S. 297-304 
    Details
    ISSN: 1432-2307
    Keywords: Key words Serum prostate-specific antigen ; Prostate carcinoma ; Prostatic intraepithelial neoplasia ; Benign prostatic hyperplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Serum prostate markers, in particular prostate-specific antigen (PSA), have truly revolutionised all aspects of the management of men with prostatic carcinoma (PCa), the most important application being related to its early detection and screening. Several studies have shown the clinical utility of PSA levels for staging patients with PCa, especially when associated with other parameters, such as tumour grade, digital rectal examination and transrectal ultrasound findings, to establish the likelihood of disease extension outside the gland and of positive lymph nodes. Also, serum PSA levels are useful in monitoring patients either after the initial diagnosis of PCa or following therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050450
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Neuroendocrine peptides in the prostate (1995)
    Springer
    Urological research 23 (1995), S. 81-87 
    Details
    ISSN: 1434-0879
    Keywords: Prostate ; Prostate carcinoma ; Neuropeptides ; Neuroendocrine cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Circulating androgens are required for normal growth and maintenance of function of the prostate. However, the prostate also contains neuroendocrine peptides, found either in nerve terminals or in prostatic neuroendocrine cells, which are likely to regulate prostate growth or function. The neuronal peptides are likely to participate in the regulation of the synthesis and secretion of prostatic secretory products. While the function of the neuroendocrine cells is undefined, there is evidence for growth-regulating effects of several neuroendocrine cell peptides. Since neuroendocrine differentiation has been correlated with tumor grade and poor prognosis in prostate cancer, the peptide products of the neuroendocrine cells may influence cancer cell replication as well. Recent evidence in other tissues suggests that peptide hormone receptor second-messenger systems may interact with steroid receptors to modulate their actions. These findings raise the possibility that prostatic neuroendocrine peptides may modulate the response of prostate to androgens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307937
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  • 5
    Electronic Resource
    Electronic Resource
    Endopeptidase 24.11 activity in the human prostate cancer cell lines LNCaP and PPC-1 (1997)
    Springer
    Urological research 25 (1997), S. 113-116 
    Details
    ISSN: 1434-0879
    Keywords: Prostate cancer ; Endopeptidase 24.11 ; Growth ; LNCaP ; PPC-1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human endopeptidase 24.11 (EP) occurs in greatest abundance on terminally differentiated prostate cells; thus, loss of EP could mark dedifferentiation of prostate epithelium. To identify laboratory models that would permit continuous work on the biochemistry and hormonal regulation of EP, we examined the well-differentiated LNCaP and poorly differentiated PPC-1 human prostate cancer cell lines. Ultrastructural analysis revealed that LNCaP secretes electron-dense material that resembles the particulate matter of seminal plasma, which is associated with endopeptidase activity. LNCaP medium contained EP activity while PPC-1 medium did not. Whether the apparent deletion of EP from the PPC-1 cell line is characteristic of poorly differentiated prostate adenocarcinoma is not yet clear. However, it may be relevant to the carcinogenic process that EP can limit growth of lung small carcinomas by inactivating cell growth-promoting bombesin-like peptides. Because bombesin has been identified in aggressive human prostate cancers, loss of EP in PPC-1 could represent a necessary step in transformation to aggressive phenotype. The combination of LNCaP and PPC-1, which offers well-differentiated and poorly differentiated cancer phenotypes, appears well suited to studying the relevance of EP in prostate cancer biology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01037925
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