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  • 1
    Electronic Resource
    Electronic Resource
    Atrial Natriuretic Peptide Content in Rat Superior Cervical Ganglion After Denervation and Axotomy (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 54 (1990), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1990.tb02363.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Catecholamine Glucuronidation: An Important Metabolic Pathway for Dopamine in the Rat (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 40 (1983), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: In the present study, we found that large quantities of dopamine (DA) glucuronide were present in rat cerebrospinal fluid (CSF), plasma, and urine, whereas the glucuronides of norepinephrine (NE) and epinephrine (E) were almost undetectable. The high urinary excretion of DA glucuronide was in a range comparable to that of homovanillic acid (HVA). Sulfates of DA, NE, and E were measurable in all three body fluids, but only in small quantities. The measured DA glucuronide was predominantly of endogenous origin, as the feeding of sucrose instead of routine diet did not reduce the urinary output of DA glucuronide. Adrenalectomy but not peripheral sympathectomy induced by chronic guanethidine injection substantially decreased plasma DA glucuronide concentrations, indicating that the adrenals serve as an important source of endogenous DA glucuronide. The data suggest that glucuronidation constitutes an important metabolic pathway for endogenous DA of central and peripheral origin in rats; this route, however, is exclusive to DA and appears to play a negligible role for NE and E.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1983.tb13587.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of l-DOPA on the Concentrations of Free and Sulfoconjugated Cathecholamines in Plasma, Cerebrospinal Fluid, Urine, and Central and Peripheral Nervous System Tissues of the Rat (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 44 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effects of subeutaneous injection of l-β-3,4-dihydroxyphenylalanine (l-DOPA) on the concentrations of the catecholamines and catecholamine sulfates in the central and peripheral nervous Systems of the rat were studied. The results showed that free 3,4-dihydroxyphenylethylamine (DA, dopamine) increased rapidly and markedly in the hypothalamus and striatum after l-DOPA but DA sulfate did not change. Increased concentrations of DA sulfate were detected in the CSF and in the plasma, where it reached a concentration of 130.8 ± 12.8 ng/ml at 2 h, seven times the level of free DA (19.1 ± 2.9 ng/ml). In the kidney the ratio of DA sulfate to free DA was reversed in favor of free DA. Urine samples of l-DOPA-treated rats showed a higher increase of free DA than DA sulfate, but free norepinephrine (NE) and NE sulfate remained unchanged. Concentrations of free DA and free NE in the adrenal glands of l-DOPA-treated rats showed no change. Adrenal DA sulfate and NE sulfate were not detectable in the control and l-DOPA-treated rats, suggesting that the adrenal glands lack the capacity to take up or store catecholamines and their sulfate counterparts from the plasma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb12884.x
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  • 4
    Electronic Resource
    Electronic Resource
    Idiopathic hypovolemia: a self-perpetuating autonomic dysfunction? (1998)
    Springer
    Clinical autonomic research 8 (1998), S. 341-346 
    Details
    ISSN: 1619-1560
    Keywords: Idiopathic hypovolemia ; episodic hypertension ; hypotension ; catecholamines ; dopamine sulfate ; renin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Unexplained episodic hypertension, hypotension, or orthostatic intolerance, tachycardia, anxiety, and flushing in 21 patients were investigated for the possibility of hypovolemia by blood volume and individual plasma catecholamines (including autocrine paracrine-born dopamine), determinations baseline, in response to upright posture and catecholamines only during the episodic blood pressure swings. Blood volume was determined by Cr51 fixed to patients' hemoglobin, free norepinephrine, epinephrine, and dopamine with dopamine sulfate following sulfatase hydrolysis, radioenzymatically. The recumbent mean 27.4±3% (SE) blood volume decrease from predicted values accentuating to 33.5±4% upright was associated with normal baseline plasma free norepinephrine, epinephrine, dopamine, dopamine sulfate, plasma renin activity, and aldosterone with normal mean postural responses from all patients except a hyperresponsive compared to controls (p〈0.04), plasma renin activity increase from 0.657±0.1 to 4.47±1.8 ng/mL/hr. During the hypertensive, hypotensive, or tachycardic episodes the moderate increase of free norepinephrine and epinephrine (p〈0.04) (but not free dopamine) contrasted with an increase of dopamine sulfate from 2.5±0.9 to clearly pathological values of 16.8±8.3 ng/mL (p〈0.0003 on % increase of individual values). We conclude that the normal (but to the degree of hypovolemia inappropriately low orthostatism- and episodes-associated sympathetic arousal) is outpaced by considerable episodic dopamine sulfate surges, reflecting extraneuronal dopamine discharge. Whether this increase contributes to the increased natriuresis directly or by inhibiting aldosterone response to renin-angiotensin, perpetuating hypovolemia, remains to be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02309625
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Species differences in the distribution of adrenal free and sulfoconjugated catecholamines (1985)
    Springer
    Journal of comparative physiology 155 (1985), S. 367-371 
    Details
    ISSN: 1432-136X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We determined free and sulfoconjugated catecholamines (CA) in adrenals of several species by reverse-phase high performance liquid chromatography (HPLC) with electrochemical detection. The two main adrenal CA, free epinephrine (E) and norepinephrine (NE) from eight species (guinea-pig, rat, dog, mice, bovine, cat, green-monkey and human) were considerably different both in the total amount as well as their relative proportions. Free dopamine (DA) content also differed from species to species but this CA was present in a relatively constant proportion, representing about 1% of the total free CA. Phenolsulfotransferase (PST) activity was present in all of the adrenals. Sulfoconjugated CA, however, were only selectively present: E and NE sulfate were entirely absent but in most of these species DA sulfate was detected in a proportion corresponding to 1–10% of the total (free + sulfoconjugated) DA. The adrenal DA sulfate concentrations did not parallel the adrenal PST activity, indicating that this enzyme can not be considered to be an index of the CA sulfates present in this organ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687480
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    Paper (German National Licenses)
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