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  • 1
    Electronic Resource
    Electronic Resource
    Kinetics and mechanism of oxidation of leucine by chloramine-T in alkaline media (1975)
    Springer
    Monatshefte für Chemie 106 (1975), S. 13-18 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Alkaline media oxidation of leucine by chloramine-T has been investigated. A first order dependence in chloramine-T and leucine and a near inverse first order dependence in hydroxide ion has been observed. Ionic strength had negligible effect while the effect of methanol addition was slightly negative. The oxidation process has been shown to proceed via two paths, one involving p-toluenesulfochloramide as the main oxidising species and the other involving hypochlorite ion, each interacting in a slow step with a leucine molecule leading to formation of monochloroleucine acid, which subsequently interacts with another molecule of p-toluenesulfochloramide or hypochlorite ion resp., yielding products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00914495
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanism of the oxidation of cycloheptanone by chloramine-T (1975)
    Springer
    Monatshefte für Chemie 106 (1975), S. 863-869 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The oxidation kinetics of cycloheptanone by chloramine-T in alkaline media has been investigated. A mechanism involving the formation of an intermediate by the interaction between the enolic anion of cycloheptanone and chloramine-T in a slow step followed by its interaction with another molecule of chloramine-T in a fast step leading to products has been proposed. The scheme satisfactorily accords with the observed stoichiometry, negligible influence of ionic strength and a positive dielectric effect. Various rate parameters have been computed and 1.2-cycloheptanedione identified as the end product.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00900865
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Endosonography of the Anal Canal and Rectum (2000)
    Springer
    World journal of surgery 24 (2000), S. 208-215 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Endosonography has evolved into an effective tool for the accurate preoperative assessment of anorectal pathology, from idiopathic anal pain to malignancy. The published data suggest that endosonography is currently the best method for assessing the structural integrity of the anal sphincter and for staging rectal cancer. The development of new treatment modalities for rectal cancer, including local excision, preoperative radiotherapy, and total mesorectal excision, has increased the importance of accurate preoperative staging to allow the optimum treatment planning. However, there is little information about the impact of endosonographic findings on clinical decision making. Education, training, and quality control in the use of endosonography also require further work. This article aims to evaluate the usefulness and limitations of this technique in clinical practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002689910034
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Renal reabsorption of phosphate during development: tubular events (1988)
    Springer
    Pediatric nephrology 2 (1988), S. 129-134 
    Details
    ISSN: 1432-198X
    Keywords: Phosphate ; Proximal tubule ; Development ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Studies performed in our laboratory on the isolated perfused kidney of the guinea pig have demonstrated that the rate of Pi reabsorption is substantially greater in the newborn than in the adult, when appropriate corrections are being made either for differences in glomerular filtration rate (GFR) or in renal tubular mass. In order to determine the location of this enhanced reabsorption along the nephron, micropuncture experiments were performed on euvolemic, non-fasted guinea pigs 5–14 and 42–49 days of age, maintained on standard guinea-pig chow diet (0.76% Pi). Concomitant measurements of overall kidney function were also obtained. The results confirmed that fractional reabsorption of Pi (TRPi%) across the entire kidney was significantly higher (P〈0.01) in the newborn (89.93±2.55%) than in the adult (78.25±2.89%) animals. The difference was also significant (P〈0.05) when TRPi was expressed in mol/ml GFR (1.87±0.14 vs 1.53±0.12, respectively). At comparable locations along the proximal tubule (TF/Pin of 1.90±0.16 in the newborn, and 1.79±0.15 in the adult,P〉0.70), the fraction of the filtered load of Pi reabsorbed was significantly higher (P〈0.001) in the immature (76.66±2.74%) than in the mature (67.21±2.74%) guinea pigs. Estimates based on the differences between proximal Pi reabsorption and the urinary excretion of Pi indicate that the reabsorption of Pi in tubular segments located beyond the proximal tubule is also enhanced in the newborn when compared with the adult (15.62±2.11% vs 10.51±1.83%, respectively,P〈0.05). Alternatively, this finding may be interpreted to represent a higher fractional reabsorption of Pi by deep nephrons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870393
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  • 5
    Electronic Resource
    Electronic Resource
    The Effect of Selected Classical Music and Spontaneous Imagery on Plasma β-Endorphin (1997)
    Springer
    Journal of behavioral medicine 20 (1997), S. 85-99 
    Details
    ISSN: 1573-3521
    Keywords: music ; imagery ; β-endorphin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract This study explored the effect of music and imagery on plasma β-endorphin in 78 undergraduates. Subjects screened for relevant psychological and health criteria were assigned to music imaging, silent imaging, music listening, and control conditions. Subjects donated 15 ml of blood prior to and following the 2-hr intervention period. There were no group differences in potential confounding variables. Split-plot factorial analysis controlling for individual differences in pretest level of β-endorphin revealed that those in the music imaging group experienced a significant pre–post decline in β-endorphin, while no other group demonstrated any significant pre–post difference. These data suggest that music imaging may lower peripheral β-endorphin levels in healthy subjects. Further exploration of the effects of music and imagery interventions on physiology and health may be warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1025543330939
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Sertraline in Diabetic Neuropathy: Preliminary Results (1997)
    Springer
    Annals of clinical psychiatry 9 (1997), S. 255-257 
    Details
    ISSN: 1573-3238
    Keywords: Antidepressant ; diabetes mellitus ; neuropathy ; pain ; blood levels ; serotonin treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous research has shown that antidepressants have been useful in the treatment of pain, particularly diabetic neuropathy. This study was an initial open investigation into the use of sertraline in diabetic neuropathy. Eight patients with diabetic neuropathy but not depression were treated with increasing doses of sertraline to a maximum of 150 mg/day for 8 weeks. Sertraline treatment led to significant reductions in mean visual analog scale (VAS) ratings, e.g., pain from 71.2 to 23.1 (t = 3.74, p 〈 .01) and paresthesias from 53.8 to 15.0 (t = 4.15, p 〈 .01). Baseline platelet serotonin (5HT) content also correlated significantly with improvement in pain (r = 0.70, p = 05). Plasma sertraline (SRT) correlated with improvement in paresthesias (r = 0.70). Conclusion: This preliminary result indicates the potential application of sertraline to treatment of diabetic neuropathy. A replication is now underway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022360528151
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  • 7
    Electronic Resource
    Electronic Resource
    Nefazodone Treatment of Adolescent Depression: An Open-Label Study of Response and Biochemistry (2000)
    Springer
    Annals of clinical psychiatry 12 (2000), S. 97-100 
    Details
    ISSN: 1573-3238
    Keywords: depression ; adolescent ; nefazodone ; antidepressants ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The purpose of this study was to find whether nefazodone, effective in adult depression, might be similarly improve symptoms of adolescent depression. Secondary purpose was to relate platelet serotonin content to response, and to find if nefazodone's effect on platelet content was similar to that of the SSRIs. Method: 10 adolescents meeting DSMIV criteria for major depression received up to 400 mg of nefazodone for an eight week period. Response was assessed at baseline, 1, 2, 4, and 8 weeks by BDI and HDRS; platelet serotonin (5HT) content was obtained at baseline and final visit (for two dropouts, this was done at last visit, i.e., week 4). Results: In LOCF analysis, significant improvement was found in both HDRS (20.9 to 8.9, p = .01) and BDI (24.6 to 10.2, p = .01). Eight of nine patients with available data showed increases in platelet 5HT content (.02). In seven patients of eight completers with available data, there was a nonsignificant trend for patients with platelet 5HT baseline greater than 30 ng/108 platelets to show a greater change in HDRS than those with a baseline of less than 30 ng/108 platelets (p = .07). Conclusions: Further double-blind study of nefazodone in adolescent depression is indicated; nefazodone appears to increase platelet 5HT content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009024214337
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