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  • 1
    Electronic Resource
    Electronic Resource
    Renal reabsorption of phosphate during development: tubular events (1988)
    Springer
    Pediatric nephrology 2 (1988), S. 129-134 
    Details
    ISSN: 1432-198X
    Keywords: Phosphate ; Proximal tubule ; Development ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Studies performed in our laboratory on the isolated perfused kidney of the guinea pig have demonstrated that the rate of Pi reabsorption is substantially greater in the newborn than in the adult, when appropriate corrections are being made either for differences in glomerular filtration rate (GFR) or in renal tubular mass. In order to determine the location of this enhanced reabsorption along the nephron, micropuncture experiments were performed on euvolemic, non-fasted guinea pigs 5–14 and 42–49 days of age, maintained on standard guinea-pig chow diet (0.76% Pi). Concomitant measurements of overall kidney function were also obtained. The results confirmed that fractional reabsorption of Pi (TRPi%) across the entire kidney was significantly higher (P〈0.01) in the newborn (89.93±2.55%) than in the adult (78.25±2.89%) animals. The difference was also significant (P〈0.05) when TRPi was expressed in mol/ml GFR (1.87±0.14 vs 1.53±0.12, respectively). At comparable locations along the proximal tubule (TF/Pin of 1.90±0.16 in the newborn, and 1.79±0.15 in the adult,P〉0.70), the fraction of the filtered load of Pi reabsorbed was significantly higher (P〈0.001) in the immature (76.66±2.74%) than in the mature (67.21±2.74%) guinea pigs. Estimates based on the differences between proximal Pi reabsorption and the urinary excretion of Pi indicate that the reabsorption of Pi in tubular segments located beyond the proximal tubule is also enhanced in the newborn when compared with the adult (15.62±2.11% vs 10.51±1.83%, respectively,P〈0.05). Alternatively, this finding may be interpreted to represent a higher fractional reabsorption of Pi by deep nephrons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870393
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Nefazodone Treatment of Adolescent Depression: An Open-Label Study of Response and Biochemistry (2000)
    Springer
    Annals of clinical psychiatry 12 (2000), S. 97-100 
    Details
    ISSN: 1573-3238
    Keywords: depression ; adolescent ; nefazodone ; antidepressants ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The purpose of this study was to find whether nefazodone, effective in adult depression, might be similarly improve symptoms of adolescent depression. Secondary purpose was to relate platelet serotonin content to response, and to find if nefazodone's effect on platelet content was similar to that of the SSRIs. Method: 10 adolescents meeting DSMIV criteria for major depression received up to 400 mg of nefazodone for an eight week period. Response was assessed at baseline, 1, 2, 4, and 8 weeks by BDI and HDRS; platelet serotonin (5HT) content was obtained at baseline and final visit (for two dropouts, this was done at last visit, i.e., week 4). Results: In LOCF analysis, significant improvement was found in both HDRS (20.9 to 8.9, p = .01) and BDI (24.6 to 10.2, p = .01). Eight of nine patients with available data showed increases in platelet 5HT content (.02). In seven patients of eight completers with available data, there was a nonsignificant trend for patients with platelet 5HT baseline greater than 30 ng/108 platelets to show a greater change in HDRS than those with a baseline of less than 30 ng/108 platelets (p = .07). Conclusions: Further double-blind study of nefazodone in adolescent depression is indicated; nefazodone appears to increase platelet 5HT content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009024214337
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The Effect of Selected Classical Music and Spontaneous Imagery on Plasma β-Endorphin (1997)
    Springer
    Journal of behavioral medicine 20 (1997), S. 85-99 
    Details
    ISSN: 1573-3521
    Keywords: music ; imagery ; β-endorphin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract This study explored the effect of music and imagery on plasma β-endorphin in 78 undergraduates. Subjects screened for relevant psychological and health criteria were assigned to music imaging, silent imaging, music listening, and control conditions. Subjects donated 15 ml of blood prior to and following the 2-hr intervention period. There were no group differences in potential confounding variables. Split-plot factorial analysis controlling for individual differences in pretest level of β-endorphin revealed that those in the music imaging group experienced a significant pre–post decline in β-endorphin, while no other group demonstrated any significant pre–post difference. These data suggest that music imaging may lower peripheral β-endorphin levels in healthy subjects. Further exploration of the effects of music and imagery interventions on physiology and health may be warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1025543330939
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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