ISSN:
0749-1581
Keywords:
1H NMR
;
13C NMR monomethyl/dimethyl 5α-androstan-3-ones
;
Steroid
;
Ring A conformation
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Ring A proton shifts and couplings and 13C shifts of all carbons are given for 17β-acetoxy-2α-methyl- and 17β-methoxy-2β-methyl-5α-androstan-3-one and 2,2-dimethyl-17β-methoxy-5α-androstan-3-one. It was concluded that the 2β-methyl derivative exists with ring A in a regular chair conformation while the 2β-methyl derivative exists with ring A in an inverted boat conformation with C-2 and C-5 at the bow/stern positions. The data for 2,2-dimethyl-17β-methoxy-5α-androstan-3-one suggest an equilibrium of these two conformers.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260250814
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