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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 34 (1988), S. 267-271 
    ISSN: 1432-1041
    Keywords: Raynaud's phenomenon ; ketanserin ; serotonin S2-blockade ; 99MTc-pertechnetate scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The severity of the peripheral vasopastic condition in 10 patients with Raynaud's phenomenon was investigated using scintigraphy of both hands. 99MTc-pertechnetate was used as a diffusable tracer and scintigrams were recorded with normal hand skin temperature and following immersion of the hands in ice-cold water. Cold provocation resulted in a marked reduction of the rate of blood inflow and tissue perfusion in affected hands. The selective peripheral S2-antagonist ketanserin and placebo were administered intra-arterially according to a double-blind cross-over design. As compared to placebo, ketanserin significantly improved the rate of inflow following cold provocation, and it increased tissue perfusion in the hands of the patients to values normally observed in healthy individuals. The results support the use of ketanserin in the treatment of Raynaud's phenomenon.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1084
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 243 (1996), S. 594-598 
    ISSN: 1432-1459
    Keywords: Single photon emission computed tomography ; Visual hallucinosis ; Ischaemic cerebrovascular disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 64-year-old right-handed man acutely developed elementary visual hallucinations (monochromatic, moving geometrical figures), visual illusions (distortion of the right side of faces) with achromatopsia and blurred vision restricted to the left visual hemi-field. CT of the brain before and after administration of contrast medium and a repeat examination 2 months later showed no abnormalities, while brain mapping (power analysis of EEG) demonstrated theta wave slowing of the curve over the posterior part of the right hemisphere.99mTC HMPAO SPECT of the brain, however, demonstrated an area of definite focal hypoperfusion in the right occipito-temporal region. Echo-Doppler-duplex and continuous wave examination of the cervical arterial blood vessels disclosed bilateral discrete atheromatous plaques that did not affect the blood flow. Transoesophageal echocardiography demonstrated slight mitral valve insufficiency. Cerebral angiography showed an occlusion of the right posterior cerebral artery. After the visual hallucinations had subsided, SPECT showed partial normalization of the right occipito-temporal perfusion. In the absence of CT evidence for a structural lesion in the clinically suspected areas, only functional imaging revealed an obviously significant lesion. This case furthermore demonstrates that SPECT can contribute to the identification of the pathophysiology underlying visual hallucinosis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Rheologica acta 27 (1988), S. 575-579 
    ISSN: 1435-1528
    Keywords: Clusterviscosity ; cluster dimension ; molecularliquid ; moltenmetal ; moltensalt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Abstract The Fulcher-Tammann-Hesse-Vogel equation, lnη = A + B/(T − T 0 ), is shown to be equivalent to the general viscosity-composition relationship, lnη r =k f ϕ/(1 − f ϕ), for binary mixtures. The Cailletet-Mathias law of the Rectilinear Diameter is rearranged to represent a density mixture formula for two components. Temperature-independent viscosities and densities can then be calculated for dense, solid cluster fractions, dispersed in a low-density, low-viscosity non-clustered continuous phase. The cluster fraction decreases with temperature. The value ofT 0 is shown to be related to the liquid- or solid-like behavior of the clusters. For liquids with a vapor pressure 〈 1 mm Hg at the melting point, the calculated cluster volume fraction suggests close packing of clusters, ranging in shape from monodisperse spheres to polydisperse non-spherical particles. Examples are given for molecular liquids, molten metals, and molten salts. The size of the clusters is estimated from the heat of evaporation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Rheologica acta 23 (1984), S. 424-434 
    ISSN: 1435-1528
    Keywords: Viscosity-composition relationship ; dispersion ; solution ; binary liquid system ; activation energy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Abstract An equation for the viscosity of a mixture of two imaginary Newtonian liquids is derived. In the derivation the mathematical assumption is used that the effective activation energy for viscous flow of a binary liquid mixture is a linear combination of the reciprocals of the activation energy of the components. It contains two dependent fitting constants and has the same structure as the Mooney equation for dispersions of spherical solid particles, the Huggins equation for polymer solutions and is identical to an equation by Hoffmann and Rother, when written in the variables that the last authors used. As a consequence it can be shown that the viscosity of binary liquid mixtures, liquid resion solutions, dispersions of solid spherical particles and polymer solutions can be described very well by one and the same equation, up to the highest concentrations. It has further been found that the viscosity of dispersions of non-spherical particles, solutions of solids in organic solvents and solutions of electrolytes and non-electrolytes in water can also be described by this formula. The equation permits the construction of a straight line on which all liquids can be plotted. An algebraic analysis of the equation shows that each series of viscosity composition data can be placed in one of three rheological groups independent of the type of fraction that is used to characterize the composition. Seventy-four binary systems, covering a wide range of liquids have been used to show the applicability of the developed equation. It has been found that in most cases the data are best described by splitting them into two regions, each with its own set of dependent constants.
    Type of Medium: Electronic Resource
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