Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Inability of galactoside-specific mistletoe lectin to inhibit N-methyl-N-nitrosourea-induced tumor development in the urinary bladder of rats and to mediate a local cellular immune response after long-term administration (1998)
    Springer
    Journal of cancer research and clinical oncology 124 (1998), S. 73-87 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Extracts from mistletoe (Viscum album L.) are assumed to exert an antineoplastic activity through their toxicity at high doses or by immunomodulation by nanogram quantities of a lectin. They are used as an unconventional therapy modality in the management of a wide range of cancer diseases, although no anticancer potential has yet been demonstrated. This prompted us to study the effect of galactoside-specific lectin (VAA) – a major protein constituent of mistletoe with immunomodulatory properties – on chemically induced tumor development in the urinary bladder of rats and on the local cellular immune response after long-term administration. To induce urothelial neoplasms N-methyl-N-nitrosourea (MNU) was administered in a single intravesical dose (7.5 mg/kg body weight). Highly purified VAA was given subcutaneously at its immunomodulatory dose (1 ng/kg body weight) twice a week over the total experimental period of 15 months. The incidences of epithelial bladder tumors were 25.0% following administration of MNU alone and 22.9% in the rats additionally receiving VAA, which proved not to be significantly different (P = 0.81). Quantitative immunohistochemistry analyzing a panel of immune cell types, including T lymphocytes, T helper/inducer cells (CD4), T suppressor/cytotoxic cells (CD8), T cells positive for interleukin-2 receptor (CD25), B lymphocytes and plasma cells, macrophages, natural killer cells, granulocytes and all leukocytes expressing the leukocyte common antigen (CD45), yielded no evidence for the ability of VAA to stimulate a substantial cellular immunological reaction in the wall of the normal urinary bladder or during urothelial carcinogenesis. In conclusion, the current experimental findings provide no support at all that the galactoside-specific mistletoe lectin is capable of inhibiting chemically induced bladder carcinogenesis and triggering a local cellular immune response after prolonged application. It thus seems highly improbable that commercial mistletoe preparations or VAA will be effective in the management of human bladder cancer by a cell-mediated immunological mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050138
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Fall-Kontroll-Studien zur Erkennung von beruflichen Faktoren für Blasenkrebs (1989)
    Springer
    Sozial- und Präventivmedizin 34 (1989), S. 249-255 
    Details
    ISSN: 1420-911X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Une étude rétrospective de l'exposition professionnelle et du style de vie d'environ 700 hommes et femmes souffrant de cancers urogénitaux (dont 94% de cancer de la vessie), et de contrôles appariés pour l'âge et le sexe a été conduite en Basse-Saxe (région de Göttingen). Les données concernant la profession comprenaient la durée et l'exercice de la profession ainsi que l'exposition à certaines substances dont la liste était présentée durant l'interview; les données concernant le style de vie (consommation de tabac, d'alcool, de médicaments, emploi de cosmétiques) étaient également relevées. Les risques les plus élevées (après correction pour l'effet du tabac) concernent les professions liées au gaz combustible, les conducteurs de camion et de locomotive et les professions du métal.
    Abstract: Summary The occupations and life-style factors of 531 male bladder cancer patients were compared with matched hospital controls; risk estimates were obtained as odds ratios of discordant pairs. The case-control study as a «fishing approach» for occupational risk factors has proven successfully that established hazards for cancer could be confirmed (e g smoking, bladder infections, mining and chemical exposures), and others were identified for the first time in Germany (vehicle driving, spray painting, oil- and petroleum exposures). Not only could smoking-adjusted risk estimates be statistically confirmed but also trends of risk increasing with duration of occupational exposure were determined. Logistic regressions were performed to determine the influence of life-style factors on occupational risks.
    Notes: Zusammenfassung Eine retrospektive Erhebung von persönlichen Angaben über berufliche Expositionen und zum Lebensstil von rund 700 Männern und Frauen mit Urogenitaltumoren (94% davon Blasenkrebs) und alters- und geschlechtsgleichen Kontrollpersonen wurde im niedersächsischen Raum um Göttingen durchgeführt. Detaillierte Angaben zum Beruf betrafen Dauer der Beschäftigung sowie eine während des Interviews präsentierte Liste bekannter und vermuteter Risikosubstanzen und -expositionen sowie der entsprechenden Einwirkungen in Hobby und Freizeit. Angaben zum Lebensstil umfassten Tabakkonsum, Alkoholgenuss, Medikamentengebrauch, Kosmetika (Haarfärbemittel) und Miktionsgewohnheiten. Die Auswertung der Angaben von 531 männlichen Krebsfällen (und Kontrollen) nach Dauer und Art der Beschäftigung wurden auch mittels Angaben zum Tabakkonsum korrigiert. Die höchsten Risikoraten (relatives Risiko) fanden sich in den Berufen Gaswerksarbeiter, Lastwagen- und Lokomotivführer, Bergarbeiter und Metallwerker, wie Dreher, sowie für Weber, Sattler und Schneider. Risikoerhöhungen für Hütten- und Giessereiarbeiter, in der Gummi- und Plastikindustrie sowie für Chemiker und Kunstmaler liessen sich statistisch nicht sichern. Exposition gegenüber Ölen im Beruf, Metallstaub (speziell Chrom, Zink, Blei, Nickel, Zinn, Aluminium und Fluorverbindungen) und nichtmetallischen Verbindungen (Lösungsmittel, Farben und Sprühfarben) war mit einem erhöhten Krebsrisiko assoziiert, zT ansteigend mit der Expositionsdauer (Öle und Petroleum). Einflüsse des Confoundings infolge Tabak-, Alkohol- und Kaffeegenuss, speziell aber der Gesamtflüssigkeitsmenge wurden in einem multiplen logistischen Modell berücksichtigt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02083218
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Detection of metastasis-associated differences for receptors of glycoconjugates (lectins) in histomorphologically unchanged xenotransplants from primary and metastatic lesions of human colon adenocarcinomas (1989)
    Springer
    Clinical & experimental metastasis 7 (1989), S. 571-584 
    Details
    ISSN: 1573-7276
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinically applicable markers for tumor progression may be uncovered by selective analysis of biochemical parameters, supposedly participating in this complex process. Owing to the importance of specific protein-carbohydrate interactions in diverse biological processes, the pattern of the receptor part in this glycobiochemical recognition system, the sugar receptors (lectins), conceivably reflects biological properties of tumor cells in glycobiochemical terms. Therefore, we established and characterized xenografts from surgically removed specimens of a human primary colon adenocarcinoma and its metastatic lesions to liver of the same patient and of a histomorphologically similar primary colon adenocarcinoma of another patient in nude mice. Xenotransplantation and subsequent glycobiochemical analysis of material from early passages with a standardized procedure had been preferred to cell culture in monolayer on account of maintenance of a higher degree of organized histotypic assembly. Despite histomorphological similarities, the sugar receptor profile revealed significant differences in tumor-tumor and tumor-metastasis comparison, especially forα -and β-galactoside-binding proteins. Tumor-metastasis differences were substantiated by a second successfully xenotransplanted pair of specimens. Comprehensive expansion of these initial data may eventually lead to desirable functional correlations with the different biological properties of histomorphologically similar primary colon adenocarcinomas and of the metastatic phenotype and to a rational development of therapeutic modalities to restrict tumor growth and spread.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01753816
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...