Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
15 (1968), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract— —(1) Major organs of rats fed a 40 per cent galactose diet for one month were surveyed for changes in free myo-inositol. The levels were reduced only in lens and sciatic nerve.(2) In nerve and lens the low myo-inositol level was associated with high concentrations of galactitol and increased water content.(3) In nerve and lens myo-inositol levels returned towards normal during a period of 1–2 weeks in which animals were fed a regular diet again. The pattern of change showed (a) an initial lag period, and (b) return to normal after galactitol concentrations had fallen to a low level and at the same time that water content returned to normal.(4) In nerve there were changes in scyllo-inositol levels that paralleled those in myoinositol.(5) The evidence suggests that the inositol changes were related to the osmotic effects of galactitol accumulation rather than to a direct inhibition of myo-inositol synthesis or uptake.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1968.tb11636.x
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