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  • 1
    Electronic Resource
    Electronic Resource
    Metastasis of Breast Carcinoma to Rectus Abdominis Muscle (2003)
    Oxford, UK : Blackwell Science Inc
    The @breast journal 9 (2003), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-4741.2003.09112.x
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship of the distribution of leu-2+ cells with suppressor cell activities in the spleen and lymphnodes from gastric cancer (1987)
    Springer
    Surgery today 17 (1987), S. 72-77 
    Details
    ISSN: 1436-2813
    Keywords: Leu-2+ cells ; suppressor cells ; lymphoid organ ; gastric cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tissue distributions of Leu-2+ cells in the spleen and draining lymphnodes in cases of clinical gastric cancer were investigated, with special reference to suppressor cell function. Significantly higher Concanavalin-A (Con-A) induced suppressor cell activities were evident in spleen cells (SCs), as compared with peripheral blood lymphocytes (PBLs). As for the tissue distribution, the proportion of Leu-2+ (cytotoxic/suppressor) cells within Leu-1+ cells was higher in the spleen than in the lymphnodes without metastasis. On the other hand, in lymphnodes with metastasis, the enhanced spontaneous suppressor cell activity was noted. In addition, the proportion of Leu-2+ cells within Leu-1+ cells was the greatest in the lymphnodes with metastasis, among the lymphoid organs tested. In lymphnodes without metastasis, lower suppressor cell activities were noted, and numerous Leu-3+ (helper/inducer) cells were present, while Leu-2+ cells were less frequent. NK cell activity against K-562 cells was enhanced by elimination of Leu-2+/OKT-8+ cells with complement-mediated lysis. These results suggest that Leu-2+ cells located in the spleen and lymphnodes with metastasis may predominantly act as suppressor cells and interact with effector cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470644
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of the oral or intratumoral administration of OK432 on the immuno-reactivities of regional lymph nodes in gastric cancer patients (1991)
    Springer
    Surgery today 21 (1991), S. 297-303 
    Details
    ISSN: 1436-2813
    Keywords: OK432 ; oral administration ; intratumoral administration ; regional lymph nodes ; gastric cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of OK432, a streptococcal preparation, administered either orally (PO-OK432) or intratumorally (IT-OK432) on the immuno-reactivities of regional lymph nodes were investigated in gastric cancer patients. Although native lymph node lymphocytes (LNL) from untreated patients did not show any cytotoxicities against K562 and Raji cells, enhanced activities were found in LNL from patients administered OK432. Augmenting effects on the cytotoxicities of LNL byin vitro additional OK432, interleukin 2 or γ-interferon were remarkable in the patients given IT-OK432. Moreover, the cytotoxicities of peripheral blood lymphocytes were augmentedin vitro more strongly in patients given IT-OK432 than in those given PO-OK432. Flow cytometric analysis of LNL revealed a decrease in CD4+ cells by PO-OK432 and an increase in CD8+ cells by IT-OK432. An increase in CD4+2H4+ cells and a decrease in CD4+2H4− cells were observed in the patients given OK432, though CD8+CD11+ cells decreased by PO-OK432 while CD8+CD11+ cells increased by IT-OK432. Thus, it is suggested that LNL reactive to OK432 immunotherapy may differ between PO- and IT-OK432, and that the immunoreactivities of local lymph nodes and systemical immuno-reactivities may be highly potentiated by IT-OK432 rather than PO-OK432.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470950
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  • 4
    Electronic Resource
    Electronic Resource
    Primary squamous cell carcinoma of the breast after cured Hodgkin's disease (1993)
    Springer
    Surgery today 23 (1993), S. 81-84 
    Details
    ISSN: 1436-2813
    Keywords: breast cancer ; squamous cell carcinoma ; Hodgkin's disease ; double cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An unusual case of primary squamous cell carcinoma of the breast occurring after cured Hodgkin's disease is reported herein. A 27-year-old woman developed a left breast mass 2 years after chemotherapy and radiation for nodular sclerosing stage IIB Hodgkin's disease. Excisional biopsy revealed squamous cell carcinoma of the breast and a modified radical mastectomy was performed, however, no metastasis was found in the axillary nodes. She received etoposide, mitomycin-C, and doxifluoridine as adjuvant chemotherapy, and remains well without any evidence of recurrent Hodgkin's disease or breast cancer. To our knowledge, this is the first reported case of primary squamous cell carcinoma of the breast associated with Hodgkin's disease. The risk of patients treated for Hodgkin's disease developing breast cancer as a second malignant neoplasm is discussed following the report of this case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309006
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of intraperitoneal administration of OK-432 for patients with advanced cancer (1985)
    Springer
    Surgery today 15 (1985), S. 260-265 
    Details
    ISSN: 1436-2813
    Keywords: advanced cancer patients ; cancerous ascites ; OK-432 ; infiltrating cells ; host immunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of intraperitoneal administration of OK-432 on tumor cells in ascites, in relation to the infiltration of effector cells and on the immune reponses of the host, particularly, with regard to immune suppressive mechanisms, were investigated in 25 patients with cancerous ascites. The effects of OK-432 depended on frequency of the repeated and continuous administrations through a tube placed in the peritoneum during laparotomy. Infiltrations of neutrophils and lymphocytes were observed in the ascites within a short period after the administration and monocyte infiltration followed. Disappearance of tumor cells correlated well with the infiltration of these cells. No marked changes in the proliferative responses of peripheral blood lymphocytes were noted and decreases in serum inhibitory factor levels in sera were observed in patients given larger doses of OK-432. A marked reduction in Concanavalin-A-induced suppressor cell activities was observed after OK-432 administration. OK-432 administration probably leads to a disappearance of tumor cells by enhancing peritoneal effector cell activities and by inhibiting the induction of suppressor cell activities, in a dose dependent manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469915
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    Paper (German National Licenses)
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