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  • 1
    Electronic Resource
    Electronic Resource
    Glutamate Inhibition of the Adrenergic-Stimulated Production of Melatonin in Rat Pineal Gland In Vitro (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 62 (1994), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of l-glutamate on the adrenergic-stimulated release of melatonin in the rat pineal gland was examined using an in vitro perfusion system. l-Glutamate by itself had no effect on melatonin secretion whereas l-glutamate administered prior to (–)-isoproterenol (β-adrenergic agonist) and l-phenylephrine (α-adrenergic agonist) inhibited melatonin production by 42%. l-Glutamate did not inhibit melatonin secretion when glands were stimulated with (–)-isoproterenol alone. d-Glutamate, as well as the l-glutamate agonists kainate, N-methyl-d-aspartate, quisqualate, and trans-1-aminocyclopentane-1, 3-dicarboxylic acid, had no effect on the (–)-isoproterenol-and l-phenylephrine-stimulated secretion of melatonin, which suggests that the inhibitory effects of glutamate are not mediated via any of the known glutamate receptor subtypes. The possibility that l-glutamate may be converted to another neuroactive compound (GABA) prior to the addition of (–)-isoproterenol and l-phenylephrine is suggested by the observation that simultaneous administration of l-glutamate with (–)-isoproterenol and l-phenylephrine did not inhibit melatonin production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1994.62062241.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of a [3H]glutamate binding site in rat pineal gland: Enhanced affinity following superior cervical ganglionectomy (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 14 (1993), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Glutamate, an excitatory neurotransmitter/neuromodulator involved in cell-to-cell communication within the central nervous system, is now believed to play a role in neuroendocrine function. In this study we describe a single, saturable, stereospecific, and temperature-, time-, and pH-dependent binding site for glutamate in the pineal gland of the rat (Kd= 612 ± 23 nM, Bmax= 3.17 ± 0.33 pmol/mg protein). After removal of the sympathetic innervation to the pineal gland, [3H]glutamate binding displayed a higher apparent affinity (Kd= 412 ± 28 nM) (P 〈 0.05) without a change in binding site number (Bmax= 3.60 ± 0.24 pmol/mg protein). No difference in [3H]glutamate binding site number was observed in pineal glands obtained from animals sacrificed during the middle of the light and dark periods. These data suggest a possible modulatory role for a glutamate binding site in pineal gland function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1993.tb00483.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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