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  • 1
    Electronic Resource
    Electronic Resource
    Eosinophilic ascites (2003)
    Oxford, UK : Blackwell Science Ltd
    Cytopathology 14 (2003), S. 0 
    Details
    ISSN: 1365-2303
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2303.2003.00029.x
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  • 2
    Electronic Resource
    Electronic Resource
    CELLULAR CHANGES FOLLOWING UTERINE ARTERY EMBOLIZATION FOR THE TREATMENT OF ADENOMYOSIS[Letters fo] (2001)
    Oxford UK : Blackwell Science Ltd
    Cytopathology 12 (2001), S. 0 
    Details
    ISSN: 1365-2303
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2303.2001.0328a.x
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  • 3
    Electronic Resource
    Electronic Resource
    Differentiation towards gastric foveolar, mucopeptic and intestinal goblet cells in gallbladder adenocarcinomas (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 29 (1996), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cellular differentiation in 22 surgically removed adenocarcinomas of the gallbladder was immunohistochemically studied with antibodies specific to mucins of gastric foveolar cells (M1), (pseudo)pyloric cells (M2) and intestinal goblet cells (M3), and also with antibodies against pepsinogen II and chromogranin A. More than 70% of tumours (16 of 22 cases) displayed gastric-and/or intestinal-type differentiation, most of which (12 of 16 cases) showed both types of differentiation. Two tumours showed an organoid growth pattern similar to the normal gastric mucosa. The presence of endocrine cells positive for chromogranin A was closely related to that of gastric- and/or intestinal-type cells. The present findings clearly indicate the multidirectional differentiation of gallbladder adenocarcinomas and suggest that most gallbladder adenocarcinomas develop and progress under induction of gastric and intestinal differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1996.d01-520.x
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  • 4
    Electronic Resource
    Electronic Resource
    Histogenesis of gastric foveolar metaplasia following duodenal ulcer: a definite reparative lineage of Brunner's gland (1999)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 35 (1999), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We aimed to clarify the histogenesis of gastric metaplasia in the duodenal mucosa, particularly in association with a reparative lineage of Brunner's glands.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and resultsUsing immunohistochemical methods with recently developed antimucin monoclonal antibodies (mAbs) that distinguish foveolar and deep mucins of the gastric type, as well as mAb MIB-1, the histogenesis of gastric metaplasia was investigated in the duodenal wall of 20 surgically resected specimens. In duodenal ulcers extending into Brunner's glands with destruction of the muscularis mucosae, proliferating cells positive for MIB-1 were scattered in Brunner's glands. Interestingly, a group of proliferating cells was often seen next to the ulcerated surface. These cells were also positive for M1 (gastric-foveolar type mucin) but negative for M2 (deep gastric and Brunner glands' mucin). In regenerating ducts through granulation tissue, the proliferating cell zone was elongated, above which foveolar-type cells positive for M1 but negative for M2 were detected, indicating that the G-zone is newly established in Brunner's glands at the floor of an ulcer to produce gastric-foveolar cells. Subsequently, an organoid growth of the normal stomach mucosa is completed in the duodenum.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionsThis study indicates a possible histogenetic pathway of gastric metaplasia in close association with a reparative lineage of Brunner's glands, suggesting that the occurrence of the gastric-foveolar type epi-thelium is not a simple expansion of Brunner's duct but a true metaplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1999.00681.x
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  • 5
    Electronic Resource
    Electronic Resource
    The effects of water extracts of CagA positive or negative Helicobacter pylori on proliferation, apoptosis and connexin formation in acetic acid-induced gastric ulcer of rats (2000)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: To investigate the influence of water extracts of CagA-positive or -negative Helicobacter pylori on healing of chronic gastric ulcers and on connexin formation, proliferation and apoptosis, in acetic acid-induced chronic gastric ulcers in rats. Methods: Acetic acid was used to induce chronic gastric ulcers in rats, and a water extract of H. pylori was given by mouth every day. Connexin 32 formation was assessed using Western blotting as previously described. The frequencies of proliferating cell nuclear antigen staining and of TdT-mediated dUTP-biotin nick end labelling were examined. Results: In untreated rats, acetic acid-induced gastric ulcers healed after 14 days and the electrophoretic band corresponding to connexin 32 appeared 4 days after ulcer induction. Treatment with a water extract of H. pylori delayed ulcer healing, with the ulcers remaining unhealed even on the 14th day; healing was delayed more when treatment was with an extract of CagA-positive rather than CagA-negative H. pylori. Connexin 32 appeared earlier when treatment was with a CagA-negative rather than a CagA-positive extract, but in both cases later than in the untreated control group. Proliferating cell nuclear antigen labelling on the fourth day was seen in 14.5% ± 1.6% of mucosal cells of control group, but in 35.9% ± 1.4% and 36.5% ± 1.4% of mucosal cells treated with either VacA(+)CagA(–) and VacA(+)CagA(+) H. pylori extract, respectively. Furthermore, extracts of both H. pylori strains, especially VacA(+)Cag(+) H. pylori promoted apoptosis. Conclusions: A water extract of H. pylori increased both proliferation and apoptosis, which are related to excerbation and healing of ulcer as well as appearance of connexin 32.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.014s1199.x
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  • 6
    Electronic Resource
    Electronic Resource
    Differential p53 protein expression in stomach adenomas of gastric and intestinal phenotypes: possible sequences of p53 alteration in stomach carcinogenesis (1996)
    Springer
    Virchows Archiv 428 (1996), S. 223-227 
    Details
    ISSN: 1432-2307
    Keywords: Gastric-type adenoma ; Intestinal-type adenoma ; p53 Expression ; Mucin expression ; Carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a comparative study, the expression of p53 protein was investigated in intestinal- and gastric-type adenomas of the stomach. The former is a conventional type, which is well known to be a premalignant lesion of the stomach, but the latter is a rare, more recently noted entity. Of 28 intestinal-type adenomas, 17 (60.7%) contained more than 5% of p53 immunoreactive cells. In these adenomas, the extent of positivity for p53 protein was significantly higher in high-grade dysplasia than in low-grade dysplasia (P〈0.05), suggesting that p53 alteration plays a part in the dysplastic progression of intestinal-type adenomas. Among 18 gastric-type adenomas in which most of the tumour cells displayed gastric-type mucin, substantial expression of p53 protein was found only in the 3 tumours with high-grade dysplasia. Thus, the incidence of p53 expression was significantly higher in intestinal-type adenomas than in gastric-type adenomas (P〈0.01). These results suggest that p53 gene alteration is an earlier event in the gastric carcinogenetic sequence with the intestinal phenotype than in that with the gastric phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196694
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  • 7
    Electronic Resource
    Electronic Resource
    Sebaceous gland metaplasia in cardiac-type mucosa of the oesophago-gastric junction (1996)
    Springer
    Virchows Archiv 428 (1996), S. 297-299 
    Details
    ISSN: 1432-2307
    Keywords: Sebaceous gland ; Stomach ; Oesophagus ; Metaplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The first case of sebaceous gland metaplasia arising in cardiac-type mucosa of the oesophago-gastric junction of 71-year-old man is reported. Within cardiac glands, small nests composed of clear cells closely resembling sebaceous glands of the skin were found. Immunohistochemically, the cell nests stained positively for a monoclonal antibody 115D8 against milk-fat globule membrane (MAM-6). These cells were sometimes covered by cylindrical cells positive for foveolar-type mucin of the stomach (M1), and basal marginal cells of these nests expressed high molecular weight cytokeratins (34BE12). This study documents a new type of metaplasia of the gastric mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196704
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  • 8
    Electronic Resource
    Electronic Resource
    Heterogeneity and progression of renal cell carcinomas as revealed by DNA cytofluorometry and the significance of the presence of polyploid cells (1995)
    Springer
    Urological research 23 (1995), S. 381-386 
    Details
    ISSN: 1434-0879
    Keywords: Renal cell carcinoma ; DNA ploidy ; Polyploid cells ; Heterogeneity ; Progression ; Survival rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With special attention to the presence of polyploid cells, we examined heterogeneity and progression of renal cell carcinomas. We separated 116 blocks from 51 tumors into several specimens according to the histologic findings, and analyzed their DNA ploidy patterns. Thirty-one tumors (61%) were aneuploid, 29 of which showed intratumoral DNA ploidy heterogeneity. Diploid cell lines were observed in 47 tumors (92%). Polyploid cells in the diploid component were more frequently found in tumors with mixed diploid and aneuploid patterns than in the purely diploid tumors. Of the diploid cases, higher stage cases tended to have a higher incidence of polyploid cells than the lower stage cases. The incidence of aneuploid cases and DNA heterogeneity became greater as the tumors progressed. Aneuploid cases had a poorer outcome than did the diploid cases. If diploid cases with polyploid cells were classified as aneuploid cases, the difference in the survival rate between the diploid and aneuploid cases became more significant. Diploid renal cell carcinomas with polyploid cells may be an intermediate stage between diploidy and aneuploidy. Analyzing renal cell carcinomas for the presence of polyploid cells is useful for differentiating diploidy, which is actually aneuploid, from pure diploidy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00698739
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  • 9
    Electronic Resource
    Electronic Resource
    ’Pyloric gland-type adenoma’ arising in heterotopic gastric mucosa of the duodenum, with dysplastic progression of the gastric type (1999)
    Springer
    Virchows Archiv 435 (1999), S. 452-457 
    Details
    ISSN: 1432-2307
    Keywords: Key words Pyloric gland-type adenoma ; Heterotopic gastric mucosa ; Duodenum ; Mucin ; Histogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  ’Pyloric gland-type adenoma’ is a recently described and very rare entity. We report a case of a pedunculated polyp of the duodenal bulb showing the features of pyloric gland-type adenoma. Heterotopic gastric mucosa was found adjacent to the tumour. Immunohistochemically, the tumour cells at the surface of the polyp showed foveolar-type mucin (M1) while most other tumour cells showed deep gastric mucin (M2), displaying a pattern of differentiation similar to the normal gastric mucosa. The polyp also showed villous or papillary structures with disorganization of gastric differentiation and marked increase of proliferating in foci cells. This is the first case of pyloric gland-type adenoma found to arise in heterotopic gastric mucosa of the duodenum, showing dysplastic progression of the gastric type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050425
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