ISSN:
0894-3230
Keywords:
Organic Chemistry
;
Physical Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
The effects of several metal ions and metal ion complexes on the hydrolysis and interconversion of uridylyl(2′,5′)uridine and its 3′,5′-isomer were studied as a function of pH and metal ion concentration. The hydrolysis was shown to be markedly accelerated by Zn2+, Cd2+ and trivalent lanthanide ions and by tri- and tetraaza complexes of Zn2+. In contrast, none of these species appreciably promotes the interconversion of the 2′,5′- and 3′,5′-isomers, in spite of the fact that this reaction proceeds through the same pentacoordinated intermediate as the hydrolysis. Lanthanide ions also promote the hydrolytic dephosphorylation of uridine 2′- and 3′-monophosphates, but have a barely noticeable effect on their interconversion. The mechanisms of the metal ion-promoted reactions are discussed.
Additional Material:
9 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/poc.610060606
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