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  • 1
    Electronic Resource
    Electronic Resource
    A Multicenter, Double-Blind Study on Triple Therapy with Lansoprazole, Amoxicillin and Clarithromycin for Eradication of Helicobacter pylori in Japanese Peptic Ulcer Patients (2001)
    Oxford, UK : Blackwell Science Ltd
    Helicobacter 6 (2001), S. 0 
    Details
    ISSN: 1523-5378
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two triple therapies with lansoprazole (LPZ)/amoxicillin (AMPC)/clarithromycin (CAM) for eradication of Helicobacter pylori were studied in multicenter, double-blind fashion to evaluate the eradication rate of H. pylori and safety of eradiation treatment in Japanese patients with H. pylori-positive active gastric ulcers or duodenal ulcers.〈section xml:id="abs1-3"〉〈title type="main"〉Methods.Patients were randomly chosen for the control treatment of LPZ 30 mg twice a day (b.i.d.; Group A-LPZ-only) or the test treatments of LPZ 30 mg plus AMPC 750 mg and CAM 200 mg b.i.d. (Group B-LAC200) and LPZ 30 mg, AMPC 750 mg and CAM 400 mg b.i.d. (Group C-LAC400). All eradication treatments lasted for a period of 7 days. Successful eradication was assessed by culture and gastric histology 1 month after completion of the ulcer treatment.〈section xml:id="abs1-4"〉〈title type="main"〉Results.The eradication rates of H. pylori in the full analysis set were 0% in Group A-LPZ-only, 87.5% in Group B-LAC200 and 89.2% in Group C-LAC400 for gastric ulcer and, 4.4% in Group A-LPZ-only, 91.1% in Group B-LAC200 and 83.7% in Group C-LAC400 for duodenal ulcer. The eradication rates of Group B-LAC200 and Group C-LAC400 were 89.2% (95% CI: 84.8–93.7%) and 86.4% (95%CI: 81.5–91.3%) in total in the full analysis set, 89% (95% CI: 84.3–93.7%) and 85.3% (95%CI: 80.1–90.5%) in the per protocol set. The eradication rates in Groups B-LAC200 and group C-LAC400 were statistically significantly higher than the rate in Group A-LPZ-only for both gastric ulcer and duodenal ulcer patients (p 〈 .0001 for both).〈section xml:id="abs1-5"〉〈title type="main"〉Conclusion.A satisfactorily high H. pylori eradication rate was obtained in Japanese ulcer patients with the triple therapy regimen consisting of LPZ 30 mg, AMPC 750 mg, and CAM 200 mg b.i.d.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1523-5378.2001.00037.x
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  • 2
    Electronic Resource
    Electronic Resource
    Light and electron microscopic and autoradiographic studies onN-methyl-N-amylnitrosamine-induced rat esophageal carcinogenesis (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 83-91 
    Details
    ISSN: 1573-2568
    Keywords: esophageal cancer ; epithelial proliferation ; carcinogenesis ; N-methyl-N-amylnitrosamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to investigate the histogenesis of experimental tumors in the rat esophagus. Thirty rats received 0.0015% N-methyl-N-amylnitrosamine (MNAN) in the drinking water for 12 weeks. Another 30 rats received tap water. All rats then received tap water until sacrifice. Rats from each group were sacrificed immediately after MNAN administration, four weeks after, and eight weeks after. One hour before sacrifice, [3H]TdR was injected by tail vein to label proliferating cells. The entire esophagus and stomach were removed and processed for light and electron microscopy and autoradiography. The overall frequency of esophageal tumors after MNAN was 83% and did not differ significantly among the three experimental groups. Tumors were primarily papillomas and squamous cell carcinomas and occurred with equal frequency in the upper, middle, and lower thirds of the esophagus. No tumors were found in the squamous-lined forestomach. Electron microscopy revealed abundant tonofilaments, free ribosomes, and mitochondria accompanied by vacuoles. By autoradiography, esophageal epithelial proliferation was markedly stimulated in nontumorous mucosa from all three experimental groups. We conclude that MNAN ingestion for 12 weeks reliably produces papillomas and squamous cell carcinomas throughout the rat esophagus, but not in the squamouslined forestomach, and that MNAN stimulated marked epithelial proliferation which is accompanied by thickening of the epithelium in nontumorus esophageal mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536636
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  • 3
    Electronic Resource
    Electronic Resource
    Endoscopic local injection of early gastric carcinoma with 5-fluorouracil (1984)
    Springer
    Digestive diseases and sciences 29 (1984), S. 498-501 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We treated four patients who had early gastric carcinoma with weekly endoscopic local injections of 5-fluorouracil (5FU). In all four patients the lesions disappeared by endoscopic and biopsy examination within 12–18 weeks of treatment. None of the patients experienced side effects which are usually associated with oral or intravenous administration of 5FU. Two patients eventually underwent surgery. In one, a small focus of carcinoma was identified within the resected stomach; no evidence of carcinoma was found in the other. The remaining two patients have not submitted to surgery and are free of carcinoma by endoscopy for over 1 1/2 years. In this uncontrolled study, endoscopic local injection of 5FU appeared to be effective in treating early gastric carcinoma as assessed by endoscopic and histological criteria. Surgery remains the treatment of choice for early gastric carcinoma. However, further studies of endoscopic injection therapy are needed to determine whether this treatment is appropriate for patients with early gastric carcinoma who are not surgical candidates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296268
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of parenteral hydrocortisone sodium succinate on epithelial renewal in hamster gastric mucosa (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 1064-1069 
    Details
    ISSN: 1573-2568
    Keywords: hydrocortisone ; corticosteroids ; epithelial renewal ; epithelial proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to determine whether parenteral administration of steroids affects epithelial renewal in hamster stomach. Male golden hamsters received either hydrocortisone sodium succinate or saline intraperitoneally for three days. In the first experiment, hamsters were sacrificed 1 hr after injection of tritiated thymidine ([3]HTdR) to label proliferating cells. In the second experiment, hamsters were sacrificed hourly after a single [3H]TdR injection up to 48 hr in order to determine cell cycle time by the method of fraction of labeled mitoses. In the third experiment, hamsters were sacrificed 1, 24, and 72 hr after [3H]TdR injection for the study of epithelial migration and cell turnover time. Sections of fundic and antral mucosae were prepared for light autoradiography. Steroid treatment caused no gross or microscopic injury to gastric mucosa, but the number of [3H]TdR-labeled cells as well as the thickness of the proliferative zone were reduced significantly in fundic mucosa, but not in antral mucosa. The study of the fraction labeled mitoses indicated that steroid treatment lengthened the cell cycle time in fundic mucosa, which was due primarily to prolonged G1 and DNA synthesis phases. Furthermore, epithelial migration was significantly slower in fundic mucosa after steroid treatment, which was associated with a prolonged cell turnover time. Thus, parenteral steroids depress the entire process of epithelial renewal in hamster fundic mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535779
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of prostaglandins on ornithine decarboxylase activity in rat small intestine (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 1087-1090 
    Details
    ISSN: 1573-2568
    Keywords: ornithine decarboxylase ; small intestine ; prostaglandin E2 ; prostaglandin I2 ; feeding ; indomethacin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Role of prostaglandins on feeding-associated induction of ornithine decarboxylase in small intestine was studied. Rats received intraperitoneal injection of either saline, or 16,16-dimethyl prostaglandin E2, or TRY-200 (a stable prostaglandin I2 analog), or refeeding, after a 44 hr-fast. Four hours later, mucosae from duodenum, jejunum, and ileum were scraped for subsequent measurements of enzyme activity of ornithine decarboxylase by a radiometric technique. Refeeding resulted in a profound induction of enzyme activity throughout the small intestine. Parenteral administration of prostaglandin I2 also led to a significant induction with the level similar to refeeding. The stimulatory effect of prostaglandin I2 was completely abolished by a specific and irreversible enzyme inhibitor, difluoromethylornithine. Prostaglandin E2 had a similar but lesser effect than prostaglandin I2 on the induction of the enzyme activity. Pretreatment with indomethacin, a cyclooxygenase inhibitor had no effect on feeding-associated enzyme induction. These results indicate that although exogenous prostaglandin I2 appears to be a potent stimulant for ornithine decarboxylase activity in rat small intestine, endogenous prostaglandins seem to play little or no role in feeding-associated induction of ornithine decarboxylase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01295725
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of long-term sucralfate ingestion on antral and fundic epithelial proliferation in the rat (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 979-983 
    Details
    ISSN: 1573-2568
    Keywords: sucralfate ; epithelial proliferation ; gastric mucosa ; tritiated thymidine autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sucralfate accelerates the healing of chronic gastric ulcers, but its mechanism is not well understood. We studied the effect of long-term administration of sucralfate on gastric epithelial proliferation in the rat by means of tritiated thymidine autoradiography. Rats were treated perorally with 500 mg/kg sucralfate once a day. After 28 days, rats were injected with tritiated thymidine 1µCi/g body weight and sacrificed 1 hr later. Autoradiographs from antral and fundic mucosae were prepared and a number of proliferative measurements were made. Long-term sucralfate administration produced an increase in tritiated thymidine labeling of epithelial cells and expansion of the proliferative zone in antral mucosa. These results indicate that long-term sucralfate ingestion stimulates gastric antral epithelial proliferation in the rat. In light of the fact that chronic gastric ulcers are usually located in the antral region in humans, this enhanced epithelial proliferation may contribute to the beneficial effect of sucralfate in accelerating the healing of gastric ulcers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02091540
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