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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of biological characteristics of EDTMP complexes with ^9^9^mTc, ^1^1^1In and ^1^5^3Sm in rats
    Amsterdam : Elsevier
    Applied Radiation and Isotopes 45 (1994), S. 949-953 
    Details
    ISSN: 0969-8043
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0969-8043(94)90234-8
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and plasma protein binding of two platinum cytostatics CHIP and CBDCA in rats (1986)
    Springer
    Cancer chemotherapy and pharmacology 17 (1986), S. 133-136 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma protein binding and pharmacokinetic parameters of CHIP (cis-dichloro-trans-dihydroxy-bisisopropylamine platinum IV) and CBDCA (cis-diammine-1,1-cyclobutane dicarboxylate platinum II) were investigated in male Wistar rats. The plasma clearance of total and non-protein-bound platinum was determined and compared with that of 99mTc-DTPA. for binding experiments, a novel, simple, and quick method based on adsorption of non-protein-bound platinum species to charcoal was used. The clearance of total platinum after CHIP and CBDCA administration was markedly lower than the glomerular filtration rate (determined as the clearance of 99mTc-DTPA). The renal clearance of non-proteinbound platinum corresponded to 168% and 50% of the glomerular filtration rate for CHIP and CBDCA, respectively. These studies suggested that CHIP was excreted by the rat kidney.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306741
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Protein binding of tolfenamic acid in the plasma from patients with renal and hepatic disease (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 591-596 
    Details
    ISSN: 1432-1041
    Keywords: tolfenamic acid ; renal failure ; liver disease ; salicylic acid ; plasma protein binding ; drug distribution in blood ; cell membrane binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The protein binding of tolfenamic acid in plasma from patients with renal and hepatic disorders was studied by equilibrium dialysis. Drug binding to the cellular components of whole blood and blood cell suspensions was also measured. Salicylic acid was used as the reference drug in all experiments. Renal and hepatic diseases increased the unbound fraction of tolfenamic acid. Free drug fractions were significantly correlated with changes in creatinine, urea, and total bilirubin, but not with those in albumin or total protein in plasma. Comparison of the theoretical binding parameters in control plasma and similar changes in protein binding in all the plasma samples studied revealed that tolfenamic acid and salicylic acid probably share a common primary binding site. The significance of the correlation permits use of salicylic acid as a model drug for predicting changes in the protein binding of tolfenamic acid. The measurements of binding properties in whole blood and blood cell — buffer suspension showed that tolfenamic acid interacts with the lipid membrane structures of blood cells, while salicylic acid is distributed into the aqueous cell space.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542420
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    Paper (German National Licenses)
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