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  • 1
    Electronic Resource
    Electronic Resource
    Conservation of autosomal gene synteny groups in mouse and man (1978)
    [s.l.] : Nature Publishing Group
    Nature 274 (1978), S. 160-163 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Chinese hamster x mouse somatic cell hybrids31 segregating mouse chromosomes (independent primary clones) were scored for the expression of murine enzymes including seven for which the gene loci had not yet been assigned in the mouse: PEP-S, PEP-D, LDH-A, ID-2, PK-3, HK-1 and PP. The mouse ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/274160a0
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  • 2
    Electronic Resource
    Electronic Resource
    Mouse chromosome 5 codes for ecotropic murine leukaemia virus cell-surface receptor (1978)
    [s.l.] : Nature Publishing Group
    Nature 274 (1978), S. 60-62 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 Correlation between I-gp71 binding and replication of murine leukaemia viruses in hamster x mouse hybrid cells 125I-gp71 binding/virus No. of replication clones No. of primary clones with: MuLV tested + / + -/- +/- -/+ % Discordancy Ecotropic viruses RLV 18 9 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/274060a0
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  • 3
    Electronic Resource
    Electronic Resource
    Control of lysosomal acid phosphatase expression in man-mouse cell hybrids (1974)
    Springer
    Biochemical genetics 11 (1974), S. 121-139 
    Details
    ISSN: 1573-4927
    Keywords: gene expression ; gene mapping ; lysosomal enzymes ; cell fusion ; gel electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Lysosomal acid phosphatase activity in human and mouse cells was separated into multiple zones by starch gel electrophoresis. One of the two major zones in the mouse was apparently extinguished when genetic information from man and the mouse was combined in proliferating man-mouse somatic cell hybrids. The evidence suggested that the absence of the mouse lysosomal acid phosphatase (mAP-1) was influenced by the human genome. The gene coding for human acid phosphatase (hAP-1) was shown to be unlinked to the presumed human component which extinguished the mouse acid phosphatase (mAP-1). The mechanism of “extinction” is postulated to be a modification in the processing of the mouse lysosomal enzyme. A dimeric structure was suggested for acid phosphatase-1 of man, mouse, and rat since a single hybrid enzyme was expressed in man-mouse and mouse-rat somatic cell hybrids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00485769
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  • 4
    Electronic Resource
    Electronic Resource
    Mapping of mouse gamma crystallin genes on chromosome 1 (1988)
    Springer
    Biochemical genetics 26 (1988), S. 557-570 
    Details
    ISSN: 1573-4927
    Keywords: mouse ; gamma crystallin ; gene mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Restriction fragments analysis of DNA from mouse-hamster somatic-cell hybrid clones revealed that a mouse gamma crystallin cDNA hybridized to genomic sequences located on mouse chromosome 1. Identification of restriction fragment length polymorphisms (RFLPs) in the gamma crystallin sequences of inbred strains of mice permitted the further localization of the gamma crystallin genes (Cryg) to the proximal region of chromosome 1 closely linked to the loci encoding isocitrate dehydrogenase (Idh-1), a low molecular weight (LM) crystallin protein polymorphism (Len-1), and fibronectin (Fn-1). A single recombinant was observed betweenLen-1 and an RFLP in the gamma crystallin gene family, consistent with the hypothesis thatLen-1 is one of the several structural loci encoding gamma crystallin genes.Len-1 is probably located on the centromeric end of theCryg gene family. Linkage ofIdh-1, Cryg, andFn-1 in mice extends the syntenic relationship of those loci to the human, bovine, and rodent genomes and may define a chromosomal region that is generally conserved among mammals. The map position ofCryg, near the eye lens obsolescence (Elo) locus, was confirmed by the discovery that the restriction fragment patterns of gamma crystallin sequences differed between strain C3H/HeJ and the congenic anophthalmic mutant strain, C3H.Elo. Therefore, the gamma crystallin genes were contransferred with the mutantElo gene in the derivation of C3H.Elo. The results establish that LEN-1 is a marker for the gamma crystallin gene family, position the gamma crystallin gene family relative to other markers on mouse chromosome 1, and provide additional evidence that theElo mutation is encoded at a locus closely linked to the gamma crystallin gene cluster. This study found no evidence of recombination hot spots within the gamma crystallin gene cluster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02399601
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  • 5
    Electronic Resource
    Electronic Resource
    Mapping of mouse gamma crystallin genes on chromosome 1 (1988)
    Springer
    Biochemical genetics 26 (1988), S. 557-570 
    Details
    ISSN: 1573-4927
    Keywords: mouse ; gamma crystallin ; gene mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Restriction fragments analysis of DNA from mouse-hamster somatic-cell hybrid clones revealed that a mouse gamma crystallin cDNA hybridized to genomic sequences located on mouse chromosome 1. Identification of restriction fragment length polymorphisms (RFLPs) in the gamma crystallin sequences of inbred strains of mice permitted the further localization of the gamma crystallin genes (Cryg) to the proximal region of chromosome 1 closely linked to the loci encoding isocitrate dehydrogenase (Idh-1), a low molecular weight (LM) crystallin protein polymorphism (Len-1), and fibronectin (Fn-1). A single recombinant was observed betweenLen-1 and an RFLP in the gamma crystallin gene family, consistent with the hypothesis thatLen-1 is one of the several structural loci encoding gamma crystallin genes.Len-1 is probably located on the centromeric end of theCryg gene family. Linkage ofIdh-1, Cryg, andFn-1 in mice extends the syntenic relationship of those loci to the human, bovine, and rodent genomes and may define a chromosomal region that is generally conserved among mammals. The map position ofCryg, near the eye lens obsolescence (Elo) locus, was confirmed by the discovery that the restriction fragment patterns of gamma crystallin sequences differed between strain C3H/HeJ and the congenic anophthalmic mutant strain, C3H.Elo. Therefore, the gamma crystallin genes were contransferred with the mutantElo gene in the derivation of C3H.Elo. The results establish that LEN-1 is a marker for the gamma crystallin gene family, position the gamma crystallin gene family relative to other markers on mouse chromosome 1, and provide additional evidence that theElo mutation is encoded at a locus closely linked to the gamma crystallin gene cluster. This study found no evidence of recombination hot spots within the gamma crystallin gene cluster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553779
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  • 6
    Electronic Resource
    Electronic Resource
    Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse (1987)
    Springer
    Somatic cell and molecular genetics 13 (1987), S. 581-586 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The genes encoding the two plasminogen activators, tissue plasminogen activator and urokinase, were mapped to mouse chromosomes using probes derived from the respective mouse cDNAs. DNA from mouse-Chinese hamster and mouse-rat somatic cell hybrids was digested with BamHI and EcoRI, respectively, and analyzed by Southern blot hybridization for the segregation of the two genes. Tissue plasminogen activator and urokinase cosegregated with mouse chromosomes 8 and 14, respectively. The plasminogen activator genes thus fall into two syntenic groups that are conserved in human and mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01534500
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  • 7
    Electronic Resource
    Electronic Resource
    Chromosomal assignments of mouse connexin genes, coding for gap junctional proteins, by somatic cell hybridization (1992)
    Springer
    Somatic cell and molecular genetics 18 (1992), S. 351-359 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The connexin genes Cx31 and Cx45 coding for proteins of gap junctional subunits have been assigned to mouse chromosomes 4 and 11 by Southern blot hybridization of specific gene probes to DNA from mouse × Chinese hamster somatic cell hybrids. In addition, our results confirm the recent assignment of mouse connexin genes Cx26, Cx32, Cx37, Cx40, Cx43, and Cx46 to mouse chromosomes 14, X, 4, 3, 10, and 14, respectively, by analysis of interspecific backcrosses and by somatic cell hybridization. Our assignment of the Cx31 gene to mouse chromosome 4 locates the fourth connexin gene on this mouse chromosome to which the genes for Cx31.1, Cx37, and Cx30.3 have previously been assigned. Interestingly three of them (coding for Cx31, Cx31.1, and Cx30.3) are preferentially expressed in skin. Possibly some of the connexin genes clustered on mouse chromosome 4 may be regulated coordinately.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01235758
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  • 8
    Electronic Resource
    Electronic Resource
    Assignment ofLIPA, associated with human acid lipase deficiency, to human chromosome 10 and comparative assignment to mouse chromosome 19 (1981)
    Springer
    Somatic cell and molecular genetics 7 (1981), S. 345-358 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The genetics of lysosomal acid lipase (LIP) has been investigated in human-Chinese hamster and mouse-Chinese hamster somatic cell hybrids. Cellulose acetate electrophoresis of human fibroblast extracts demonstrated that LIP activity consists of three isozymes. A deficiency of LIP activity has been observed in Wolman's disease (WD), cholesterol ester storage disease (CESD), and I-cell disease (ICD); this deficiency was associated with only one LIP isozyme, LIPA. We have demonstrated concordant segregation between human LIPA and human chromosome 10 and its enzyme marker glutamate oxaloacetate transaminase-1 (GOT1) in cell hybrid clones. Previous evidence suggested the different mutations associated with WD and CESD to be in the structural gene which we assign to human chromosome 10, while a different gene, involved in the processing of LIPA, is altered in ICD. These results indicate that several types of gene products are involved in the final expression of LIPA. In mouse-Chinese hamster hybrid clones, mouseLip-1 (homologous to humanLIPA) was assigned to chromosome 19. Previously, mouseGot-1 has been assigned to chromosome 19. Thus, theLIPA-GOT1 linkage group has remained intact during the 80×106 years of evolution that separates humans and mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01538859
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  • 9
    Electronic Resource
    Electronic Resource
    Mouse kidney renin gene is on chromosome one (1984)
    Springer
    Somatic cell and molecular genetics 10 (1984), S. 633-637 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The structural gene for mouse kidney renin (Ren-1)was localized to chromosome 1 by Southern blot analysis of mouse-hamster somatic cell hybrids with a cloned mouse submandibular renin cDNA probe. The submandibular renin gene (Ren-2)also lies on chromosome 1; so it may be, in those mouse lines which carry it, a tandem duplication of the kidney-type Ren-1gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535229
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  • 10
    Electronic Resource
    Electronic Resource
    Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9 (1987)
    Springer
    Somatic cell and molecular genetics 13 (1987), S. 689-693 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Lactotransferrin (LTF), a member of the transferrin family of genes, is the major iron-binding protein in milk and body secretions. The amino acid sequence of LTF consists of two homologous domains homologous to proteins in the transferrin family. Recent isolation of cDNA encoding mouse LTF has expedited the mapping of both mouse and human LTF genes. Southern blot analysis of DNA from mouse-Chinese hamster and human-mouse somatic cell hybrids maps the LTF gene to mouse chromosome 9 and to human chromosome 3, respectively. Furthermore, analysis of cell hybrids containing defined segments of human chromosome 3 demonstrates that the gene is located in the 3q21-qter region. These results suggest that LTF and associated genes of the transferrin family have existed together on the same chromosomal region for 300–500 million years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01534490
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