Bibliothek

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    Digitale Medien
    Digitale Medien
    Intracellular Signaling and Genetic Reprogramming during Agonist-Induced Hypertrophy of Cardiomyocytes (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 752 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb17443.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    L-propionylcarnitine and myocardial performance in stunned porcine myocardium (1992)
    Springer
    Molecular and cellular biochemistry 116 (1992), S. 147-153 
    Details
    ISSN: 1573-4919
    Schlagwort(e): stunned myocardium ; systemic hemodynamics ; regional contractile function ; L-propionylcarnitine ; pig
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Recently, we showed that L-propionylcarnitine did not affect recovery of regional contractile function of porcine myocardium subjected to 1 h of low-flow ischemia followed by 2 hr of reperfusion. In that study, ischemia may have been too severe and/or the duration of reperfusion too short to detect a beneficial effect of the compound. Therefore, in the present study we investigated the effects of saline (control group; n = 14) or pretreatment with L-propionylcarnitine (3 days of 50 mg/kg p.o. b.i.d. + 50 mg/kg i.v. prior to the experiment; n = 13) on recovery of regional contractile function of the myocardium in open-chest anesthetized pigs, subjected to two cycles of 10 min of left anterior descending coronary artery (LADCA) occlusion, each followed by 30 min of reperfusion. In the control animals, at the end of the second reperfusion period, systemic vascular resistance had increased by 18%, which, however, was not observed in the L-propionylcarnitine-treated pigs. In the control group, during the first occlusion, systolic segment length shortening (SSLS) of the LADCA-perfused area decreased from 18.5 ± 5.5% to - 3.7 = 3.2%. After 30 min of reperfusion, SSLS of the LADCA-perfused area had only partially recovered to 6.2 ±5.9%. During the second occlusion-reperfusion cycle similar values for SSLS were observed. In the treated animals., SSLS of the LADCA-perfused area was slightly improved after the second occlusion-reperfusion cycle (p = 0.056). This effect did not result in an overall improvement in cardiac pump function. We conclude that in a model of myocardial stunning, L-propionylcarnitine prevents systemic vasoconstriction in response to ischemia and reperfusion and, possibly as a result of this effect, slightly ameliorates post-ischemic hypofunction. (Mol Cell Biochem116: 147–153, 1992)
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01270582
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia (1993)
    Springer
    Cardiovascular drugs and therapy 7 (1993), S. 801-807 
    Details
    ISSN: 1573-7241
    Schlagwort(e): trimetazidine ; myocardial ischemia ; reperfusion ; regional myocardial perfusion and function ; external work ; oxygen free radicals ; high energy phosphates
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We evaluated the effect of trimetazidine (TMZ) on recovery of regional cardiac function in anesthetized open-chest pigs, subjected to fifteen 2-minute occlusions of the left anterior descending coronary artery, separated by 2 minutes of reperfusion and a 120-minute recovery period. Regional myocardial function was evaluated by sonomicrometry-derived segment lengthening and the area enclosed by the left ventricular pressure-segment length loop (external work, EW) in animals, which received either an intracoronary infusion of TMZ (33 µg/kg/min, n=6) or saline (1 ml/min, n=7), starting 15 minutes before the first occlusion and ending 2 minutes after the 15th occlusion. In addition, myocardial malondialdehyde production to evaluate oxygen free radical production, oxygen consumption, and the ATP, ADP, and AMP content, as well as the energy charge, were determined at regular time intervals. In control pigs the sequences of occlusion-reperfusion did not affect systemic hemodynamics, except for the LVdP/dtmax, which decreased by 11% during the interventions and did not recover during the following reperfusion period of 2 hours (78% of baseline, p〈0.05). Systolic segment length shortening and EW were increased at the end of the first occlusion-reperfusion cycle, decreased gradually during the remainder of the occlusion-reperfusion periods, and did not improve during the recovery period. Energy charge and myocardial blood flow were not impaired, but oxygen consumption was decreased during the recovery period. The malondialdeyde data did not provide evidence for production of oxygen free radicals. TMZ decreased LVdP/dtmax by 6% (p〈0.05) and caused a twofold increase in postsystolic segment shortening (p〈0.05) before the first occlusion, but did not influence the hemodynamic responses, the changes in regional cardiac function, and the metabolic events produced by repetitive regional ischemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00878934
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    The influence of fish oil diet and norepinephrine treatment on fatty acid composition of rat heart phospholipids and the positional fatty acid distribution in phosphatidylethanolamine (1986)
    Springer
    Basic research in cardiology 81 (1986), S. 289-302 
    Details
    ISSN: 1435-1803
    Schlagwort(e): phospholipids ; fish oil diet ; catecholamines ; polyunsaturated fatty acids ; positional fatty acid distribution
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of chronic norepinephrine (NE) administration with increasing dosage from 1–4 mg/kg over a period of 2 weeks was studied on cardiac phospholipids and their fatty acid distribution in rats. Animals were fed a control diet or a 10% cod liver oil (CLO)-enriched diet. The relative distribution of various polyunsaturated fatty acids esterified to the 1- and 2-position of the phosphatidylethanolamine fraction was estimated. NE stress during control feeding significantly reduced the total phospholipid content in rat heart. No differences in the phospholipid class distribution were found. However, CLO feeding as well as chronic NE administration resulted in a decrease of ω 3 fatty fatty acids, mainly C 18:2 ω 6 and C 20:4 ω 6, which was compensated with an increase in ω 3 fatty acids, mainly C 20:5 ω 3 and C 22:6 ω 3. The changes in fatty acid composition qualitatively agree with those reported by Gudbjarnason et al. (23), except that the mortality in our NE-treated control or CLO-fed groups was considerably lower. It can probably be attributed to a different mode of NE administration. On the other hand, at the end of the CLO feeding period in rats treated with NE or not, comparing with control fed rats without NE treatment, the incidence rate of ST segment elevation in electrocardiogram (ECG) recorded under light diethylether-induced anesthesia was higher. Independent of whether the fatty acid composition of myocardial phospholipids was dietary or pharmacologically manipulated, most of the polyunsaturated fatty acids were found at the 2-position of the phosphatidylethanolamine molecules. The polyunsaturated fatty acids account for 45–50% of the fatty acyl residues and preferentially occupy the 2-position, where they can exchange for each other.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01907412
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 5
    Digitale Medien
    Digitale Medien
    The effects of dietary mackerel oil on plasma and cell membrane lipids, on hemodynamics and cardiac arrhythmias during recurrent acute ischemia in the pig (1986)
    Springer
    Basic research in cardiology 81 (1986), S. 567-580 
    Details
    ISSN: 1435-1803
    Schlagwort(e): fish oil ; phospholipids ; myocardial ischemia ; ventricular arrhythmias ; cardiac function ; prostaglandins
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Fish-oil nutrition leads to a change in fatty acid composition of cellular membranes. To investigate whether this affects cardiac responses to acute myocardial ischemia, pigs were fed a 9.1% (w/w) mackerel-oil (n=8) or 9.1% (w/w) lard-fat diet (n=8). Eight weeks mackerel-oil feeding reduced plasmacholesterol (51%) and triglyceride (48%), while the n-6 fatty acids of cardiac and platelet membrane phospholipids were partially replaced by n-3 fatty acids. After 8 weeks the animals were anesthetized and the left anterior descending coronary artery was occluded 6 times for a period of 5 min at 15 min intervals. Recovery of cardiac function and the incidence of cardiac arrhythmias were similar for both dietary groups. However, during the last reperfusions, hyperemic responses were less in magnitude and shorter lasting in the lard-fat (81±17 ml/min) than in the mackerel-oil group (129±18 ml/min). This may be caused by a difference in thromboxane synthesis, as coronary venous blood thromboxane B2 levels were higher in the lard-fat (77±6 pg/ml) than in the mackerel-oil group (19±7 pg/ml, P〈0.05) during peak hyperemia. The low baseline levels of both thromboxane B2 and 6-keto prostaglandin Flalpha in fish-oil fed animals originate from the reduced content of precursor fatty acid in the membrane phospholipids. In conclusion, despite marked changes in membrane fatty acid composition induced by prolonged feeding with fish oil, no modification of recovery of cardiac function and of incidence of cardiac arrhythmias was found during acute recurrent ischemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02005181
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...