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  • 1
    Electronic Resource
    Electronic Resource
    Mucin Biophysics (1995)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 57 (1995), S. 635-657 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.57.030195.003223
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction of an aluminium–magnesium containing antacid and gastric mucus: possible contribution to the cytoprotective function of antacids (1997)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Antacids are generally thought to protect the gastric mucosa from damage primarily by their ability to neutralize hydrochloric acid, but recently other mechanisms of antacid cytoprotection have been suggested. The aim of our study was to determine if the antacid hydrotalcit (Mg6Al2(OH)16CO3×4H2O) and its clinical formulations Talcid (suspension and tablet) can influence the acid barrier properties of pig gastric mucus (PGM). Methods: Viscosities, flow patterns of injected HCl, and permeability to HCl were assayed in solutions of PGM with and without added antacid. Results: Talcid-suspension markedly increased mucin viscosity between pH 2 and 7. In contrast, powdered Talcid-tablet and hydrotalcit noticeably reduced mucin viscosity at pH 5 and below. HCl barely diffused through PGM-Talcid-suspension, whereas the acid was able to quickly penetrate a PGM-Talcid-tablet powder or PGM-hydrotalcit mixture. When injected into a mixture of PGM-Talcid-suspension, HCl travelled in a single distinct channel whereas in both PGM-Talcid-tablet powder or PGM-hydrotalcit mixtures, the acid mixed irregularly throughout. Experiments with antacids alone revealed that Talcid-suspension, but not Talcid-tablet nor hydrotalcit, had barrier properties similar to PGM. Conclusion: Talcid-suspension has viscoelastic features similar to gastric mucin and may afford mucosal protection by its ability to maintain or mimic the barrier properties of gastric mucus gel. In contrast, powdered Talcid-tablets and hydrotalcit reduce the barrier function of gastric mucus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.104275000.x
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  • 3
    Electronic Resource
    Electronic Resource
    Mucin: Aggregation and colloidal interactions of relevance to some biomedical problems (1994)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 16 (1994), S. 1411-1418 
    Details
    ISSN: 0392-6737
    Keywords: Physical chemistry of solutions of biological macromolecules ; Colloids ; Gels and sols ; Conference proceedings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary Mucus is the viscoelastic secretion that lines, most epithelial surfaces forming a protective, lubricating barrier. The viscoelastic properties of mucus arise from mucin, a glycoprotein of molecular weight ranging from 2–10 million. In this paper we address two problems where the aggregation and interactions of mucin with colloidal particles is of physiological relevance. The first deals with gastric mucin and the question of the mechanisms that prevent the stomach from digesting itself. Using dynamic light scattering techniques we show that solutions of gastric mucin aggregate belowpH 4. Very large aggregates with 100-fold slower diffusion constants than the mucin monomer are observed atpH 2. Viscosity measurements indicate that mucin will eventually gel at lowpH, thus acting as a diffusional, barrier and protecting the stomach. The second problem is concerned with the role of mucin in the nucleation of cholesterol crystals which lead to gallstone formation. Using dynamic light scattering we have shown that mucin at relatively low concentrations (4 mg/ml) promotes the fusion of phospholipid + cholesterol vesicles. The time evolution of the fusion process was measured. No changes in the aggregation state of the gallbladder mucin were observed during the fusion process, suggesting that this phenomenon is related to physico-chemical interactions between the polymer (mucin) and the colloidal particle (vesicle).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02462025
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    Paper (German National Licenses)
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